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Cytotoxic triterpenoids from Chisocheton pentandrus

Salam S 1 , Harneti D 2 , Maharani R 3 , Nurlelasari 2 , Safari A 2 , Hidayat AT 3 Show all authors , Lesmana R 4 , Nafiah MA 5 , Supratman U 6 , Kyle Prescott TA 7 , Shiono Y 8

Affiliations 

  • 1 Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, 45363, Indonesia; Faculty of Pharmacy, Universitas Mulawarman, Samarinda, 75123, Kalimantan Timur, Indonesia
  • 2 Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, 45363, Indonesia
  • 3 Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, 45363, Indonesia; Central Laboratory, Universitas Padjadjaran, Jatinangor, 45363, Indonesia
  • 4 Central Laboratory, Universitas Padjadjaran, Jatinangor, 45363, Indonesia; Physiology Division, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Jatinangor, 45363, Indonesia
  • 5 Department of Chemistry, Faculty of Science and Mathematics, Sultan Idris Education University, Tg Malim, 35900, Perak, Malaysia
  • 6 Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, 45363, Indonesia; Central Laboratory, Universitas Padjadjaran, Jatinangor, 45363, Indonesia. Electronic address: [email protected]
  • 7 Royal Botanic Gardens, Kew, Richmond, Surrey TW9 3AB, United Kingdom
  • 8 Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata, 997-8555, Japan
Phytochemistry, 2021 Jul;187:112759.
PMID: 33839518 DOI: 10.1016/j.phytochem.2021.112759

Abstract

Eleven undescribed triterpenoids (pentandrucines A to K) were isolated from the n-hexane extract of the stem bark of Chisocheton pentandrus (Blanco) Merr. These comprised ten undescribed dammarane-type triterpenoids and one undescribed apotirucallane-type triterpenoid. Additionally, two dammarane-type triterpenoids, four apotirucallane-type triterpenoids and two tirucallane-type triterpenoids were also isolated. The chemical structures of pentandrucine A-K, were fully elucidated using 1D and 2D-NMR, and high resolution MS. All of the compounds were evaluated for cytotoxic activity against MCF-7 breast cancer cells in vitro. Melianodiol proved to be the most active with an IC50 of 16.84 μM comparing favourably with Cisplatin (13.2 μM).

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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