Cytotoxic triterpenoids from the stem bark of Aglaia angustifolia

Hutagaol RP 1 , Harneti D 1 , Safari A 1 , Hidayat AT 1 , Supratman U 1 , Awang K 2 Show all authors , Shiono Y 3

Affiliations 

  • 1 Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km 21, Jatinangor 45363, Indonesia
  • 2 Department of Chemistry, Faculty of Sciences, University of Malaya, Kuala Lumpur 59100, Malaysia
  • 3 Department of Food, Life and Environment Sciences, Faculty of Agriculture, Yamagata University, Yamagata 9978555, Japan
J Asian Nat Prod Res, 2021 Aug;23(8):781-788.
PMID: 32536210 DOI: 10.1080/10286020.2020.1776704

Abstract

A seco-apotirucallane-type triterpenoid, namely angustifolianin (1), along with three dammarane-type triterpenoids, (20S, 24S)-epoxy-dammarane-3β,25-diol (2), 3-epi-cabraleahydroxylactone (3), and cabralealactone (4), were isolated from the stem bark of Aglaia angustifolia Miq. The Chemical structure of the new compounds was elucidated on the basis of spectroscopic data. All of the compounds were evaluated for their cytotoxic effects against MCF-7 breast cancer cells. Among those compounds, angustifolianin (1) showed strongest cytotoxic activity with an IC50 value of 50.5 μg/ml.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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