Displaying publications 1 - 20 of 24 in total

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  1. Liam CK, Pang YK, Shyamala P, Chua KT
    Med J Malaysia, 2007 Aug;62(3):268-73; quiz 274.
    PMID: 18246927
    During normal sleep the tone of the pharyngeal airway dilator muscles is decreased resulting in upper airway narrowing and increased resistance to airflow. Nasal obstruction may result from a variety of anatomical abnormalities such as septal deviation, nasal polyps, adenoid hypertrophy and rhinitis such as allergic rhinitis, acute viral rhinitis, vasomotor rhinitis and non-allergic rhinitis with nasal eosinophilia syndrome. Disordered breathing during sleep can both result from and be worsened by nasal obstruction. In children, nasal obstruction due to enlarged tonsils and adenoids results in a switch to oral breathing which may lead to the adenoid faces because of changes in the craniofacial structures during growth that predispose to disordered breathing during sleep.
    Matched MeSH terms: Sleep Apnea Syndromes/diagnosis*; Sleep Apnea Syndromes/etiology; Sleep Apnea Syndromes/physiopathology; Sleep Apnea Syndromes/therapy*
  2. Chidambaram R
    J Coll Physicians Surg Pak, 2017 May;27(5):321.
    PMID: 28599700 DOI: 2624
    Matched MeSH terms: Sleep Apnea Syndromes/diagnosis*
  3. Liam CK, How LG, Tan CT
    Med J Malaysia, 1996 Mar;51(1):143-5.
    PMID: 10967996
    Three patients involved in road traffic accidents were suspected to have obstructive sleep apnoea (OSA). Two of them fell asleep while riding motorcycles and one patient fell asleep behind the wheel of a truck causing it to overturn. The diagnosis of OSA in each case was suspected based on a history of loud snoring, restless sleep, and excessive daytime somnolence and was confirmed by sleep studies.
    Matched MeSH terms: Sleep Apnea Syndromes/physiopathology*
  4. Palaniappan R, Sundaraj K, Sundaraj S, Huliraj N, Revadi SS
    Clin Respir J, 2016 Jul;10(4):486-94.
    PMID: 25515741 DOI: 10.1111/crj.12250
    BACKGROUND: Monitoring respiration is important in several medical applications. One such application is respiratory rate monitoring in patients with sleep apnoea. The respiratory rate in patients with sleep apnoea disorder is irregular compared with the controls. Respiratory phase detection is required for a proper monitoring of respiration in patients with sleep apnoea.

    AIMS: To develop a model to detect the respiratory phases present in the pulmonary acoustic signals and to evaluate the performance of the model in detecting the respiratory phases.

    METHODS: Normalised averaged power spectral density for each frame and change in normalised averaged power spectral density between the adjacent frames were fuzzified and fuzzy rules were formulated. The fuzzy inference system (FIS) was developed with both Mamdani and Sugeno methods. To evaluate the performance of both Mamdani and Sugeno methods, correlation coefficient and root mean square error (RMSE) were calculated.

    RESULTS: In the correlation coefficient analysis in evaluating the fuzzy model using Mamdani and Sugeno method, the strength of the correlation was found to be r = 0.9892 and r = 0.9964, respectively. The RMSE for Mamdani and Sugeno methods are RMSE = 0.0853 and RMSE = 0.0817, respectively.

    CONCLUSION: The correlation coefficient and the RMSE of the proposed fuzzy models in detecting the respiratory phases reveals that Sugeno method performs better compared with the Mamdani method.

    Matched MeSH terms: Sleep Apnea Syndromes/physiopathology*
  5. Liam CK
    Med J Malaysia, 1993 Sep;48(3):347-50.
    PMID: 8183151
    A 47 year old man with a long history of chronic loud snoring and daytime sleepiness presented with hypercapnic respiratory failure and right ventricular failure. The diagnosis of obstructive sleep apnoea (OSA) leading to the 'obesity-hypoventilation syndrome', was supported by the findings of an overnight cardio-respiratory monitoring during sleep. His symptoms and arterial blood gases improved following treatment with nocturnal nasal continuous positive airway pressure (CPAP).
    Matched MeSH terms: Sleep Apnea Syndromes/complications*
  6. Viswabhargav CSS, Tripathy RK, Acharya UR
    Comput Biol Med, 2019 05;108:20-30.
    PMID: 31003176 DOI: 10.1016/j.compbiomed.2019.03.016
    Sleep is a prominent physiological activity in our daily life. Sleep apnea is the category of sleep disorder during which the breathing of the person diminishes causing the alternation in the upper airway resistance. The electrocardiogram derived respiration (EDR) and heart rate (RR-time-series) signals are normally used for the detection of sleep apnea as these two signals capture cardio-pulmonary activity information. Hence, the analysis of these two signals provides vital information about sleep apnea. In this paper, we propose the novel sparse residual entropy (SRE) features for the automated detection of sleep apnea using EDR and heart rate signals. The features required for the automated detection of sleep apnea are extracted in three steps: (i) atomic decomposition based residual estimation from both EDR and heart rate signals using orthogonal matching pursuit (OMP) with different dictionaries, (ii) estimation of probabilities from each sparse residual, and (iii) calculation of the entropy features. The proposed SRE features are fed to the combination of fuzzy K-means clustering and support vector machine (SVM) to pick the best performing classifier. The experimental results demonstrate that the proposed SRE features with radial basis function (RBF) kernel-based SVM classifier yielded higher performance with accuracy, sensitivity and specificity values of 78.07%, 78.01%, and 78.13%, respectively with Fourier dictionary and 10-fold cross-validation. For subject-specific or leave-one-out validation case, the SVM classifier has sensitivity and specificity of 85.43% and 92.60%, respectively using SRE features with Fourier dictionary (FD).
    Matched MeSH terms: Sleep Apnea Syndromes/physiopathology*
  7. Palaniappan R, Sundaraj K, Sundaraj S
    Comput Methods Programs Biomed, 2017 Jul;145:67-72.
    PMID: 28552127 DOI: 10.1016/j.cmpb.2017.04.013
    BACKGROUND: The monitoring of the respiratory rate is vital in several medical conditions, including sleep apnea because patients with sleep apnea exhibit an irregular respiratory rate compared with controls. Therefore, monitoring the respiratory rate by detecting the different breath phases is crucial.

    OBJECTIVES: This study aimed to segment the breath cycles from pulmonary acoustic signals using the newly developed adaptive neuro-fuzzy inference system (ANFIS) based on breath phase detection and to subsequently evaluate the performance of the system.

    METHODS: The normalised averaged power spectral density for each segment was fuzzified, and a set of fuzzy rules was formulated. The ANFIS was developed to detect the breath phases and subsequently perform breath cycle segmentation. To evaluate the performance of the proposed method, the root mean square error (RMSE) and correlation coefficient values were calculated and analysed, and the proposed method was then validated using data collected at KIMS Hospital and the RALE standard dataset.

    RESULTS: The analysis of the correlation coefficient of the neuro-fuzzy model, which was performed to evaluate its performance, revealed a correlation strength of r = 0.9925, and the RMSE for the neuro-fuzzy model was found to equal 0.0069.

    CONCLUSION: The proposed neuro-fuzzy model performs better than the fuzzy inference system (FIS) in detecting the breath phases and segmenting the breath cycles and requires less rules than FIS.

    Matched MeSH terms: Sleep Apnea Syndromes/diagnosis
  8. Asha'ari ZA, Hasmoni MH, Ab Rahman J, Yusof RA, Ahmad RA
    Laryngoscope, 2012 Oct;122(10):2337-42.
    PMID: 22753136 DOI: 10.1002/lary.23379
    To study the association between sleep apnea and hypertension in a younger age group than previously studied, adding upper airway sizes at endoscopy as important compounding variables not often included in the past.
    Matched MeSH terms: Sleep Apnea Syndromes/diagnosis; Sleep Apnea Syndromes/epidemiology*
  9. Raman R, Gopalakrishnan G
    Trop Doct, 1999 Jul;29(3):160-1.
    PMID: 10448240
    Matched MeSH terms: Sleep Apnea Syndromes/etiology; Sleep Apnea Syndromes/prevention & control
  10. Sung CM, Tan SN, Shin MH, Lee J, Kim HC, Lim SC, et al.
    Am J Respir Crit Care Med, 2021 07 01;204(1):103-106.
    PMID: 33826879 DOI: 10.1164/rccm.202011-4266LE
    Matched MeSH terms: Sleep Apnea Syndromes/complications*; Sleep Apnea Syndromes/therapy*
  11. Scapuccin M, Schneider L, Rashid N, Zaghi S, Rosa T, Tsou YA, et al.
    J Clin Sleep Med, 2018 04 15;14(4):641-650.
    PMID: 29609709 DOI: 10.5664/jcsm.7062
    STUDY OBJECTIVES: Patients suspected to have sleep-disordered breathing underwent an overnight polysomnography using a divided nasal cannula to gain additional information about the nasal cycle during sleep.

    METHODS: This was a prospective, observational cohort study replacing the undivided nasal cannula with a divided nasal cannula during routine polysomnography (n = 28).

    RESULTS: Integration of the divided nasal cannula pressure transducer system into routine polysomnography was easy and affordable. Most patients (89%) demonstrated nasal cycle changes during the test. Nasal cycle changes tended to occur during body position changes (62%) and transitions from non-rapid eye movement sleep to rapid eye movement sleep (41%). The mean nasal cycle duration was 2.5 ± 2.1 hours. Other sleep study metrics did not reveal statistically significant findings in relation to the nasal cycle.

    CONCLUSIONS: Replacing an undivided nasal cannula with a divided nasal cannula is easy to implement, adding another physiologic measure to polysomnography. Although the divided nasal cannula did not significantly affect traditional polysomnographic metrics such as the apnea-hypopnea index or periodic limb movement index based on this small pilot study, we were able to replicate past nasal cycle findings that may be of interest to sleep clinicians and researchers. Given the ease with which the divided nasal cannula can be integrated, we encourage other sleep researchers to investigate the utility of using a divided nasal cannula during polysomnography.

    Matched MeSH terms: Sleep Apnea Syndromes/diagnosis*; Sleep Apnea Syndromes/physiopathology
  12. Hasniah AL, Jamalludin AR, Norrashidah AW, Norzila MZ, Asiah K, Anida AR, et al.
    World J Pediatr, 2012 Feb;8(1):38-42.
    PMID: 22105571 DOI: 10.1007/s12519-011-0279-3
    Sleep-disordered breathing (SDB) is common but often underdiagnosed in children. The Pediatric Sleep Questionnaire developed by University of Michigan, USA (English UM PSQ) has high sensitivity and specificity in identifying children with sleep-disordered breathing. This study aimed to translate and adapt the English UM PSQ into Malay language as a screening tool to assess SDB among the Malay speaking population. The second objective was to determine the psychometric measurements of the translated UM PSQ (Malay UM PSQ).
    Matched MeSH terms: Sleep Apnea Syndromes/diagnosis*; Sleep Apnea Syndromes/epidemiology
  13. Ng TP, Seow A, Tan WC
    Eur Respir J, 1998 Jul;12(1):198-203.
    PMID: 9701437
    This study investigated the prevalence of snoring and symptoms of sleep breathing-related disorders in the multi-ethnic population of Singapore (3 million people, comprising 75% Chinese, 15% Malay and 7% Indian). A multistaged, area cluster, disproportionate stratified, random sampling of adults aged 20-74 yrs was used to obtain a sample of 2,298 subjects (65% response), with approximately equal numbers of Chinese, Malay and Indian and in each 10 yr age group. An interviewer-administered field questionnaire was used to record symptoms of snoring and breathing disturbances during sleep witnessed by a room-mate and other personal and health-related data. The weighted point estimate (and 95% confidence interval) of the whole population prevalence of snoring was 6.8% (53-83). There were pronounced ethnic differences among Chinese, 6.2% (4.4-8.1); Malay, 8.1% (6.1-10.2) and Indian, 10.9% (85-13.4). The minimum whole population prevalence by the most restricted symptom criteria for defining sleep breathing-related disorder was 0.43% (0.05-0.8%). Similar marked ethnic differences in rates were observed using various symptom criteria. The ethnic differences in sleep breathing symptoms paralleled the differences in body mass index, neck circumference and hypertension, but statistically significant differences remained after adjustment for sex, age and these known associated factors. Marked ethnic differences in snoring and sleep breathing-related disorders were observed in Chinese, Malays and Indians in Singapore, which were only partly explained by known factors of sex, age and body habitus.
    Matched MeSH terms: Sleep Apnea Syndromes/ethnology*; Sleep Apnea Syndromes/epidemiology
  14. Mohamad I, Hassan S, Salim R
    Malays J Med Sci, 2007 Jul;14(2):19-21.
    PMID: 22993487 MyJurnal
    Tonsillectomy is performed for several indications, the two commonest in practice are infective ( chronic tonsillitis ) and obstructive symptoms such as sleep apnea. The objective of this study is to determine the necessity of routinely performed histopathological examination of specimens post-tonsillectomy. In this paper, a retrospective evaluation of 480 specimens from 241 patient who has undergone tonsillectomies in Hospital Universiti Sains Malaysia between January 2004 and October 2005 was done. It was found that 462 ( 96.25 % ) were reactive lymphoid hyperplasia and 18 ( 3.75 % ) were follicular hyperplasia. None of them were found malignant. The result of this study indicate that routine histopathological examination of tonsillectomy specimens are unnecessary and results only in added cost and a loss of man hours.
    Matched MeSH terms: Sleep Apnea Syndromes
  15. Fadzil Abdullah AA, Jamalludin AR, Norrashidah AW, Norzila MZ, Asiah Kassim K, Rus Anida A, et al.
    Med J Malaysia, 2012 Apr;67(2):181-5.
    PMID: 22822640 MyJurnal
    Sleep disordered breathing (SDB) is increasingly being diagnosed in children. However, there is no prevalence study done in Malaysia. The study objective was to evaluate the prevalence of SDB symptoms based on parental reports and associated risk factors among Malay school children aged 6 to 10 years old in a primary school using a translated University Michigan Paediatric Sleep Questionnaire (Malay UM-PSQ). The children whose parents responded to the questionnaire and consented were examined, documenting height, weight, skin fold thickness, neck and abdominal circumference, tonsillar size, nostril examination and presence of micrognathia or retrognathia. There were 550 respondents. The prevalence of parental report of SDB symptoms was 14.9 % (95 % CI 11.9, 17.9). Two hundred and eighty-five (51.8%) school children were males with mean age of 8.5 years (SD 1.1). The associated risk factors for SDB symptoms are male, obesity, large neck and waist circumference, positive history of asthma, history of recurrent tonsillitis, enlarged tonsil (> 4+) and enlarged nasal turbinate. Multivariate analysis showed that male gender is the only significant independent risk factor of SDB symptoms
    Matched MeSH terms: Sleep Apnea Syndromes/epidemiology*
  16. Abdullah BJ, Liam CK, Kaur H, Mathew KM
    Br J Radiol, 1997 Oct;70(838):1063-5.
    PMID: 9404213
    Lipoma of the parapharyngeal space is very rare, only three cases having been reported in the literature. A parapharyngeal space lipoma causing obstructive sleep apnoea has not been reported before. A 60-year-old man presented at the ear, nose and throat (ENT) clinic with a history of loud snoring associated with sleep apnoea secondary to a right parapharyngeal space lipoma. The causes of sleep apnoea and the radiological features of a parapharyngeal space lipoma are discussed.
    Study site: ENT clinic, University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia
    Matched MeSH terms: Sleep Apnea Syndromes/etiology*
  17. Liam CK
    Med J Malaysia, 1996 Mar;51(1):82-8.
    PMID: 10967984
    The gold standard for the diagnosis and evaluation of sleep apnoea is overnight polysomnography. However, full polysomnography is an expensive and labour intensive procedure which requires the patient to sleep overnight in a hospital sleep laboratory. This paper describes the use of a commercial ambulatory microprocessor based system (Edentrace II) for the evaluation of fifteen patients aged 24 to 68 years with clinical features suggestive of sleep apnoea syndrome. With this portable recording system, sleep studies can be carried out unattended in a hospital ward and computer-assisted scoring of respiratory events can be performed.
    Study site: Chest clinic, wards, University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia
    Matched MeSH terms: Sleep Apnea Syndromes/diagnosis*
  18. Ravindran VK
    Med J Malaysia, 1983 Jun;38(2):164-6.
    PMID: 6621450
    An interesting case is described here in which partial airway obstruction resulted in sleep apnoea and which was relieved by adeno-tonsillectomy. Enlarged tonsils and adenoids causing upper airway obstruction represent one facet of a continuum of hypoventilation - sleep disorders and clinical examination with x-rays will help in determining patients at risk of developing these syndromes.
    Matched MeSH terms: Sleep Apnea Syndromes/etiology*
  19. Liam CK, Liao CM, Kannan P
    Singapore Med J, 1994 Aug;35(4):411-3.
    PMID: 7899906
    A patient had recurrent acute nocturnal pulmonary oedema following an anterior myocardial infarction despite a normal maximal stress electrocardiogram. He had a history of chronic heavy snoring and other symptoms to suggest a diagnosis of obstructive sleep apnoea (OSA) which was supported by an overnight sleep study. The recurrent acute pulmonary oedema was most likely due to a combination of poor left ventricular function and obstructive sleep apnoea.
    Matched MeSH terms: Sleep Apnea Syndromes/complications*
  20. Waseem R, Chan MTV, Wang CY, Seet E, Chung F
    PLoS One, 2021;16(5):e0250777.
    PMID: 33956830 DOI: 10.1371/journal.pone.0250777
    INTRODUCTION: In adults with cardiovascular risk factors undergoing major noncardiac surgery, unrecognized obstructive sleep apnea (OSA) was associated with postoperative cardiovascular complications. There is a need for an easy and accessible home device in predicting sleep apnea. The objective of the study is to determine the predictive performance of the overnight pulse oximetry in predicting OSA in at-risk surgical patients.

    METHODS: This was a planned post-hoc analysis of multicenter prospective cohort study involving 1,218 at-risk surgical patients without prior diagnosis of sleep apnea. All patients underwent home sleep apnea testing (ApneaLink Plus, ResMed) simultaneously with pulse oximetry (PULSOX-300i, Konica Minolta Sensing, Inc). The predictive performance of the 4% oxygen desaturation index (ODI) versus apnea-hypopnea index (AHI) were determined.

    RESULTS: Of 1,218 patients, the mean age was 67.2 ± 9.2 years and body mass index (BMI) was 27.0 ± 5.3 kg/m2. The optimal cut-off for predicting moderate-to-severe and severe OSA was ODI ≥15 events/hour. For predicting moderate-to-severe OSA (AHI ≥15), the sensitivity and specificity of ODI ≥ 15 events per hour were 88.4% (95% confidence interval [CI], 85.7-90.6) and 95.4% (95% CI, 94.2-96.4). For severe OSA (AHI ≥30), the sensitivity and specificity were 97.2% (95% CI, 92.7-99.1) and 78.8% (95% CI, 78.2-79.0). The area under the curve (AUC) for moderate-to-severe and severe OSA was 0.983 (95% CI, 0.977-0.988) and 0.979 (95% CI, 0.97-0.909) respectively.

    DISCUSSION: ODI from oximetry is sensitive and specific in predicting moderate-to-severe or severe OSA in at-risk surgical population. It provides an easy, accurate, and accessible tool for at-risk surgical patients with suspected OSA.

    Matched MeSH terms: Sleep Apnea Syndromes/diagnosis
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