Peripheral blood CD163(+) monocytes and soluble CD163 in dry and neovascular age-related macular degeneration

Daftarian N 1 , Zandi S 1 , Piryaie G 2 , Nikougoftar Zarif M 3 , Ranaei Pirmardan E 1 , Yamaguchi M 4 Show all authors , Behzadian Nejad Q 5 , Hasanpour H 5 , Samiei S 3 , Pfister IB 6 , Soheili ZS 7 , Nakao S 4 , Barakat A 1 , Garweg JG 6 , Ahmadieh H 1 , Hafezi-Moghadam A 1

Affiliations 

  • 1 Molecular Biomarkers Nano-Imaging Laboratory, Brigham and Women's Hospital, Boston, MA, USA
  • 2 Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • 3 Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
  • 4 Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
  • 5 Negah Specialty Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • 6 Swiss Eye Institute, Rotkreuz and Berner Augenklinik am Lindenhofspital, Bern, Switzerland
  • 7 Department of Molecular Medicine, Institute of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
FASEB J, 2020 Jun;34(6):8001-8011.
PMID: 32333612 DOI: 10.1096/fj.201901902RR

Abstract

Macrophages are the main infiltrating immune cells in choroidal neovascularization (CNV), a hallmark of the human wet, or neovascular age-related macular degeneration (AMD). Due to their plasticity and ability to adapt to the local microenvironment in a tissue-dependent manner, macrophages display polar functional phenotypes characterized by their cell surface markers and their cytokine profiles. We found accumulation of hemoglobin-scavenging cluster of differentiation 163 (CD163)(+) macrophages in laser-induced CNV lesions and higher expression of CD163(+) monocytes in the peripheral blood on day 7 post injury in mice. In comparison, CD80(+) macrophages did not differ with laser-injury in young or aged mice and did not significantly change in the peripheral blood of CNV mice. We examined the percentages of CD163(+), CD206(+), and CD80(+) monocytes in the peripheral blood of patients with wet AMD, patients with dry AMD, and in age-matched individuals without AMD as controls. Percentages of peripheral blood CD163(+) monocytes in both dry AMD (P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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