The synthesis of trifluoromethylated N-nitroaryl-2-amino-1,3-dichloropropane derivatives and their evaluation as potential anti-cancer agents

Chappel L 1 , Wong LC 2 , Leong CO 3 , Mai CW 4 , Meikle IT 1 , Stanforth SP 5 Show all authors , Truong TV 1

Affiliations 

  • 1 Department of Applied Sciences, Northumbria University, Newcastle upon Tyne NE1 8ST, UK
  • 2 Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University Malaysia, 57000 Kuala Lumpur, Malaysia
  • 3 Centre for Cancer and Stem Cells Research, Institute for Research, Development and Innovation, International Medical University Malaysia, 57000 Kuala Lumpur, Malaysia; Department of Life Sciences, School of Pharmacy, International Medical University Malaysia, 57000 Kuala Lumpur, Malaysia
  • 4 Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University Malaysia, 57000 Kuala Lumpur, Malaysia; Centre for Cancer and Stem Cells Research, Institute for Research, Development and Innovation, International Medical University Malaysia, 57000 Kuala Lumpur, Malaysia
  • 5 Department of Applied Sciences, Northumbria University, Newcastle upon Tyne NE1 8ST, UK. Electronic address: [email protected]
Bioorg Med Chem Lett, 2020 02 15;30(4):126910.
PMID: 31882300 DOI: 10.1016/j.bmcl.2019.126910

Abstract

Six N-nitroaryl-2-amino-1,3-dichloropropane derivatives have been prepared and evaluated against 18 cancer cell lines and two non-cancerous cell lines. Analysis of cell viability data and IC50 values indicated that the presence of a trifluoromethyl group in the nitroaryl moiety is an important structural feature associated with the compounds' cytotoxicities.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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