Patterns of linkage disequilibrium at PARK16 may explain variances in genetic association studies

Li H 1 , Teo YY 2 , Tan EK 3

Affiliations 

  • 1 Health Services Research and Biostatistics Unit, Division of Research, Singapore General Hospital
  • 2 Department of Statistics & Applied Probability, Saw Swee Hock School of Public Health, National University of Singapore
  • 3 Departments of Clinical Research and Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore, Duke NUS Graduate Medical School
Mov Disord, 2015 Sep;30(10):1335-42.
PMID: 25758099 DOI: 10.1002/mds.26176

Abstract

Reproducing genomewide association studies findings in different populations is challenging, because the reproducibility fundamentally relies on the similar patterns of linkage disequilibrium between the unknown causal variants and the genotyped single-nucleotide polymorphisms (SNPs).

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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