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LRRK2 G2385R and R1628P mutations are associated with an increased risk of Parkinson's disease in the Malaysian population

Gopalai AA 1 , Lim SY 2 , Chua JY 1 , Tey S 1 , Lim TT 3 , Mohamed Ibrahim N 4 Show all authors , Tan AH 2 , Eow GB 3 , Abdul Aziz Z 5 , Puvanarajah SD 6 , Viswanathan S 6 , Looi I 7 , Lim SK 2 , Tan LP 2 , Chong YB 2 , Tan CT 2 , Zhao Y 8 , Tan EK 8 , Ahmad-Annuar A 1

Affiliations 

  • 1 Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 2 Divisions of Neurology and Nephrology, Department of Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 3 Department of Neurology, Hospital Pulau Pinang, 10990 Penang, Malaysia
  • 4 Division of Neurology, Department of Medicine, Hospital Universiti Kebangsaan Malaysia, 56000 Kuala Lumpur, Malaysia
  • 5 Division of Neurology, Department of Medicine, Hospital Sultanah Nur Zahirah, 20400 Kuala Terengganu, Malaysia
  • 6 Department of Neurology, Hospital Kuala Lumpur, 50586 Kuala Lumpur, Malaysia
  • 7 Department of Medicine, Hospital Seberang Jaya, 13700 Penang, Malaysia
  • 8 Department of Clinical Research and Neurology, Singapore General Hospital, Singapore 169608
Biomed Res Int, 2014;2014:867321.
PMID: 25243190 DOI: 10.1155/2014/867321

Abstract

The LRRK2 gene has been associated with both familial and sporadic forms of Parkinson's disease (PD). The G2019S variant is commonly found in North African Arab and Caucasian PD patients, but this locus is monomorphic in Asians. The G2385R and R1628P variants are associated with a higher risk of developing PD in certain Asian populations but have not been studied in the Malaysian population. Therefore, we screened the G2385R and R1628P variants in 1,202 Malaysian subjects consisting of 695 cases and 507 controls. The G2385R and R1628P variants were associated with a 2.2-fold (P = 0.019) and 1.2-fold (P = 0.054) increased risk of PD, respectively. Our data concur with other reported findings in Chinese, Taiwanese, Singaporean, and Korean studies.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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