New cembrane-type diterpenoids from Bornean soft coral Nephthea sp. with antifungal activity against Lagenidium thermophilum

Tani K 1 , Kamada T 1 , Phan CS 1 , Vairappan CS 1

Affiliations 

  • 1 Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah , Kota Kinabalu , Malaysia
Nat Prod Res, 2019 Dec;33(23):3343-3349.
PMID: 29772929 DOI: 10.1080/14786419.2018.1475387

Abstract

Three new cembrane diterpenes, nephthecrassocolides A-B (1-2) and 6-acetoxy nephthenol acetate (3) along with three known compounds, 6-acetoxy-7,8-epoxy nephthenol acetate (4), epoxy nephthenol acetate (5) and nephthenol (6) were isolated from one population of Nephthea sp. Their structures were elucidated based on spectroscopic data analysis and the antifungal activities of compounds 1-6 were evaluated.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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