Three new cembranoids from the Bornean soft coral Nephthea sp

Ishii T 1 , Kamada T 1 , Vairappan CS 1

Affiliations 

  • 1 a Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation , Universiti of Malaysia Sabah , Kota Kinabalu , Malaysia
J Asian Nat Prod Res, 2016 May;18(5):415-22.
PMID: 26983053 DOI: 10.1080/10286020.2016.1145670

Abstract

Three new cembranoid diterpenes, 10-hydroxy-nephthenol acetate (1), 7,8-epoxy-10-hydroxy-nephthenol acetate (2), and 6-acetoxy-7,8-epoxy-10-hydroxy-nephthenol acetate (3), along with a known compound, 6-acetoxy-7,8-epoxy-nephthenol acetate (4), were isolated from the Bornean soft coral Nephthea sp. Antibacterial and anticancer activities were exhibited by compounds 1 and 2 against Staphylococcus aureus (ATCC 6538)/Escherichia coli (ATCC 13311) and Hela/MCF-7, respectively.

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