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Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study

Dossus L 1 , Franceschi S 2 , Biessy C 1 , Navionis AS 1 , Travis RC 3 , Weiderpass E 4 Show all authors , Scalbert A 1 , Romieu I 1 , Tjønneland A 5 , Olsen A 5 , Overvad K 6 , Boutron-Ruault MC 7 , Bonnet F 7 , Fournier A 7 , Fortner RT 8 , Kaaks R 8 , Aleksandrova K 9 , Trichopoulou A 10 , La Vecchia C 10 , Peppa E 10 , Tumino R 11 , Panico S 12 , Palli D 13 , Agnoli C 14 , Vineis P 15 , Bueno-de-Mesquita HBA 15 , Peeters PH 15 , Skeie G 4 , Zamora-Ros R 16 , Chirlaque MD 17 , Ardanaz E 17 , Sánchez MJ 17 , Ramón Quirós J 18 , Dorronsoro M 19 , Sandström M 20 , Nilsson LM 21 , Schmidt JA 3 , Khaw KT 22 , Tsilidis KK 15 , Aune D 15 , Riboli E 15 , Rinaldi S 1

Affiliations 

  • 1 Nutrition and Metabolism Section, International Agency for Research on Cancer, Lyon, France
  • 2 Infections Section, International Agency for Research on Cancer, Lyon, France
  • 3 Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
  • 4 Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
  • 5 Danish Cancer Society Research Center, Copenhagen, Denmark
  • 6 Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark
  • 7 CESP, INSERM U1018, Univ. Paris-Sud, UVSQ, Université Paris-Saclay, Villejuif Cedex, France
  • 8 Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
  • 9 German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
  • 10 Hellenic Health Foundation, Athens, Greece
  • 11 Cancer Registry and Histopathology Department, "Civic-M.P. Arezzo" Hospital, ASP Ragusa, Italy
  • 12 Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
  • 13 Cancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute - ISPO, Florence, Italy
  • 14 Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
  • 15 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
  • 16 Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
  • 17 CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
  • 18 Public Health Directorate, Asturias, Spain
  • 19 Basque Regional Health Department, Public Health Direction and Biodonostia Research Institute CIBERESP, San Sebastian, Spain
  • 20 Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden
  • 21 Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Umeå, Sweden
  • 22 Cancer Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
Int J Cancer, 2018 Apr 01;142(7):1332-1342.
PMID: 29168186 DOI: 10.1002/ijc.31172

Abstract

Other than the influence of ionizing radiation and benign thyroid disease, little is known about the risk factors for differentiated thyroid cancer (TC) which is an increasing common cancer worldwide. Consistent evidence shows that body mass is positively associated with TC risk. As excess weight is a state of chronic inflammation, we investigated the relationship between concentrations of leptin, adiponectin, C-reactive protein, interleukin (IL)-6, IL-10 and tumor necrosis factor (TNF)-α and the risk of TC. A case-control study was nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study and included 475 first primary incident TC cases (399 women and 76 men) and 1,016 matched cancer-free cohort participants. Biomarkers were measured in serum samples using validated and highly sensitive commercially available immunoassays. Odds ratios (ORs) of TC by levels of each biomarker were estimated using conditional logistic regression models, adjusting for BMI and alcohol consumption. Adiponectin was inversely associated with TC risk among women (ORT3vs.T1  = 0.69, 95% CI: 0.49-0.98, Ptrend  = 0.04) but not among men (ORT3vs.T1  = 1.36, 95% CI: 0.67-2.76, Ptrend  = 0.37). Increasing levels of IL-10 were positively associated with TC risk in both genders and significantly so in women (ORT3vs.T1  = 1.59, 95% CI: 1.13-2.25, Ptrend  = 0.01) but not in men (ORT3vs.T1  = 1.78, 95% CI: 0.80-3.98, Ptrend  = 0.17). Leptin, CRP, IL-6 and TNF-α were not associated with TC risk in either gender. These results indicate a positive association of TC risk with IL-10 and a negative association with adiponectin that is probably restricted to women. Inflammation may play a role in TC in combination with or independently of excess weight.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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