Advances in Chemistry and Bioactivity of the Genus Chisocheton Blume

Shilpi JA 1 , Saha S 2 , Chong SL 3 , Nahar L 4 , Sarker SD 4 , Awang K 5

Affiliations 

  • 1 Centre for Natural Products and Drug Discovery, University of Malaya, Kuala Lumpur, 50603, Malaysia
  • 2 Pharmacy Discipline, Life Science School, Khulna University, Khulna, 9208, Bangladesh
  • 3 Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, 50603, Malaysia
  • 4 Medicinal Chemistry and Natural Products Research Group, School of Pharmacy and Biomolecular Sciences, Faculty of Science, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool, L3 3AF, UK
  • 5 Centre for Natural Products and Drug Discovery, University of Malaya, Kuala Lumpur, 50603, Malaysia. [email protected]
Chem Biodivers, 2016 May;13(5):483-503.
PMID: 26970405 DOI: 10.1002/cbdv.201400373

Abstract

Chisocheton is one of the genera of the family Meliaceae and consists of ca. 53 species; the distribution of most of those are confined to the Indo-Malay region. Species of broader geographic distribution have undergone extensive phytochemical investigations. Previous phytochemical investigations of this genus resulted in the isolation of mainly limonoids, apotirucallane, tirucallane, and dammarane triterpenes. Reported bioactivities of the isolated compounds include cytotoxic, anti-inflammatory, antifungal, antimalarial, antimycobacterial, antifeedant, and lipid droplet inhibitory activities. Aside from chemistry and biological activities, this review also deals briefly with botany, distribution, and uses of various species of this genus.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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