Donor Diabetes and Steatosis Affects Recipient Survival Following Liver Transplantation Based on Etiology of Liver Cirrhosis

Lim WH 1 , Ng CH 2 , Tan DJH 1 , Xiao J 1 , Fu CE 1 , Ong C 1 Show all authors , Koh B 1 , Chung C 1 , Tan SN 1 , Wong ZY 3 , Mitchell K 4 , Joseph AA 4 , Tseng M 5 , Syn N 1 , Mak LY 6 , Fung J 6 , Huang DQ 1 , Muthiah M 1 , Tan EXX 1 , Siddiqui MS 5

Affiliations 

  • 1 Yong Loo Lin School of Medicine, National University of Singapore, Singapore
  • 2 Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore, Singapore
  • 3 School of Medicine, International Medical University, Kuala Lumpur, Malaysia
  • 4 Division of Transplant Surgery, Virginia Commonwealth University, Richmond, VA
  • 5 Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA
  • 6 Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
Transplantation, 2024 Feb 01;108(2):473-482.
PMID: 37439778 DOI: 10.1097/TP.0000000000004718

Abstract

BACKGROUND: Liver transplantation (LT) offers patients with decompensated cirrhosis the best chance at long-term survival. With the rising prevalence of diabetes, further clarity is needed on the impact of receiving a liver allograft from a donor with diabetes on post-LT outcomes. This study aims to evaluate the impact of donor diabetes on clinical outcomes after LT.

METHODS: This is a retrospective analysis of the United Network for Organ Sharing registry data of LT recipients from January 1, 2000, to December 31, 2021. Outcomes analysis was performed using Cox proportional model for all-cause mortality and graft failure. Confounding was reduced by coarsened exact matching causal inference analysis.

RESULTS: Of 66 960 donors identified, 7178 (10.7%) had diabetes. Trend analysis revealed a longitudinal increase in the prevalence of donor diabetes ( P  

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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