Clinical Features, Socioeconomic Status, Management, and Outcomes of Acute Heart Failure: PEACE MENA Registry Phase I Results

AlBackr H 1 , Alhabib KF 1 , Sulaiman K 2 , Jamee A 3 , Sobhy M 4 , Benkhedda S 5 Show all authors , Dada S 6 , Hammoudeh A 7 , Gamra H 8 , Al-Motarreb A 9 , Alkindi F 10 , Amin MI 11 , Yousif MG 12 , Farhan HA 13 , Fellat N 14 , Almahmeed W 15 , Jarallah MA 16 , Panduranga P 2 , Abdelhamid M 17 , Ghaly I 18 , Djermane D 5 , Chibane A 19 , Skouri H 20 , Jarrah M 21 , Amor H 22 , Alsagheer NK 23 , Hozayen MA 24 , Ahmed HS 10 , Ali M 25 , Ullah A 1 , Saleh AA 1 , Zannad F 26

Affiliations 

  • 1 Department of Cardiac Sciences, King Fahad Cardiac Center, College of Medicine, King Saud Medical City, King Saud University, Riyadh, Saudi Arabia
  • 2 National Heart Center - Royal Hospital, Muscat, Oman
  • 3 Nassar Medical Complex Hospital, Ministry of Health, Khan Younes, Gaza Strip, Palestine
  • 4 International Cardiac Center (ICC), Alexandria, Egypt
  • 5 COCRG Laboratory, Cardiology Department, Mustapha Hospital, Benyoucef Benkhedda University, Algiers, Algeria
  • 6 Cardiology Department, Hammoud Hospital University Medical Centre, Saida, Lebanon
  • 7 Cardiology Department, Istishari Hospital, Amman, Jordan
  • 8 Research Laboratory LR 12SP16, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, Tunisia
  • 9 Faculty of Medicine, Sana'a University, Yemen
  • 10 Heart Hospital, Hamad Medical Corporation, Doha, Qatar
  • 11 Mohamed Bin Khalifa Cardiac Centre, Bahrain
  • 12 Sudan Heart Centre, Khartoum, Sudan
  • 13 Iraqi Board for Medical Specializations, Baghdad Heart Center, Baghdad, Iraq
  • 14 Cardiology A department, Pole of Cardio Pneumology and Cardiothoracic Surgery, Ibn Sina University Hospital, Faculty of Medicine and Pharmacology of Rabat (FMPR), University Med V, Rabat, Morocco
  • 15 Heart and Vascular Institute, Cleveland Clinic, Abu Dhabi, United Arab Emirates
  • 16 Sabah Al Ahmed Cardiac Center, Kuwait
  • 17 Faculty of Medicine, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt
  • 18 Alhyatt Heart and Vascular Center, Alexandria, Egypt
  • 19 Internal Medicine and Cardiology Department, CHU Douéra, University Saad Dahlab, Blida, Algeria
  • 20 Cardiology Division - Internal Medicine Department at the American University of Beirut Medical Center, Beirut, Lebanon
  • 21 Division of Cardiology, Internal Medicine Department, King Abdullah University Hospital, Jordan University of Science and Technology, Irbid, Jordan
  • 22 Cardiology Department, Taher Sfar University Hospital, Mahdia, Tunisia
  • 23 Cardiology Department, Faculty of medicine, Sanaa University, Sanaa, Yemen
  • 24 Cardiology Department, Arass General Hospital, Arass, Al Qaseem, Saudi Arabia
  • 25 Saudi Heart Association, Riyadh, Saudi Arabia
  • 26 Centre d'Investigation Clinique Inserm, Institut Lorrain du Coeur et des Vaisseaux, CHU, Université de Lorraine, Nancy, France
Curr Vasc Pharmacol, 2023;21(4):257-267.
PMID: 37231723 DOI: 10.2174/1570161121666230525111259

Abstract

INTRODUCTION: PEACE MENA (Program for the Evaluation and Management of Cardiac Events in the Middle East and North Africa) is a prospective registry in Arab countries for in-patients with acute myocardial infarction (AMI) or acute heart failure (AHF). Here, we report the baseline characteristics and outcomes of in-patients with AHF who were enrolled during the first 14 months of the recruitment phase.

METHODS: A prospective, multi-centre, multi-country study including patients hospitalized with AHF was conducted. Clinical characteristics, echocardiogram, BNP (B-type natriuretic peptide), socioeconomic status, management, 1-month, and 1-year outcomes are reported.

RESULTS: Between April 2019 and June 2020, a total of 1258 adults with AHF from 16 Arab countries were recruited. Their mean age was 63.3 (±15) years, 56.8% were men, 65% had monthly income ≤US$ 500, and 56% had limited education. Furthermore, 55% had diabetes mellitus, 67% had hypertension; 55% had HFrEF (heart failure with reduced ejection fraction), and 19% had HFpEF (heart failure with preserved ejection fraction). At 1 year, 3.6% had a heart failure-related device (0-22%) and 7.3% used an angiotensin receptor neprilysin inhibitor (0-43%). Mortality was 4.4% per 1 month and 11.77% per 1-year post-discharge. Compared with higher-income patients, lower-income patients had a higher 1-year total heart failure hospitalization rate (45.6 vs 29.9%, p=0.001), and the 1-year mortality difference was not statistically significant (13.2 vs 8.8%, p=0.059).

CONCLUSION: Most of the patients with AHF in Arab countries had a high burden of cardiac risk factors, low income, and low education status with great heterogeneity in key performance indicators of AHF management among Arab countries.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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