The Potential Role of Intravenous Vitamin C Monotherapy in Critical Illness

Vitamin C is an essential micronutrient with antioxidant properties and its use in critical illness has gained interest in recent years.1 Four systematic reviews/meta-analyses (SRMAs) have been published in 2021 alone (see Table 1 summary).2-5 These 4 SRMAs included between 8-43 randomized controlled trials evaluating vitamin C with or without thiamine and/or corticosteroids in general ICU patients and those with sepsis and septic shock. 2-5 Fujii et al performed a network meta-analysis which is a method for comparing multiple treatments using both direct and indirect evidence across trials that included studies with vitamin C monotherapy or with thiamine and/or corticosteroids.9 This article is protected by copyright. All rights reserved.