Browse publications by year: 2000

  1. Mirza S, Kariuki S, Mamun KZ, Beeching NJ, Hart CA
    J Clin Microbiol, 2000 Apr;38(4):1449-52.
    PMID: 10747124
    Molecular analysis of chromosomal DNA from 193 multidrug-resistant (MDR) Salmonella enterica serovar Typhi isolates from 1990 to 1995 from Pakistan, Kuwait, Malaysia, Bangladesh, and India produced a total of five major different pulsed-field gel electrophoresis (PFGE) patterns. Even within a particular country MDR S. enterica serovar Typhi DNA was found to be in different PFGE groups. Similar self-transferable 98-MDa plasmids belonging to either incompatibility group incHI1 or incHI1/FIIA were implicated in the MDR phenotype in S. enterica serovar Typhi isolates from all the locations except Quetta, Pakistan, where the majority were of incFIA. A total of five different PFGE genotypes with six different plasmids, based on incompatibility and restriction endonuclease analysis groups, were found among these MDR S. enterica serovar Typhi isolates.
    MeSH terms: Anti-Bacterial Agents/pharmacology*; Asia/epidemiology; beta-Lactamases/biosynthesis; Chromosomes, Bacterial/genetics*; Conjugation, Genetic; DNA Restriction Enzymes/metabolism; Drug Resistance, Microbial/genetics*; Humans; Microbial Sensitivity Tests; Plasmids/genetics*; Salmonella typhi/classification; Salmonella typhi/drug effects*; Salmonella typhi/genetics; Typhoid Fever/microbiology; Typhoid Fever/epidemiology; Electrophoresis, Gel, Pulsed-Field; Drug Resistance, Multiple/genetics
  2. Stinear T, Davies JK, Jenkin GA, Portaels F, Ross BC, Oppedisano F, et al.
    J Clin Microbiol, 2000 Apr;38(4):1482-7.
    PMID: 10747130
    Two high-copy-number insertion sequences, IS2404 and IS2606, were recently identified in Mycobacterium ulcerans and were shown by Southern hybridization to possess restriction fragment length polymorphism between strains from different geographic origins. We have designed a simple genotyping method that captures these differences by PCR amplification of the region between adjacent copies of IS2404 and IS2606. We have called this system 2426 PCR. The method is rapid, reproducible, sensitive, and specific for M. ulcerans, and it has confirmed previous studies suggesting a clonal population structure of M. ulcerans within a geographic region. M. ulcerans isolates from Australia, Papua New Guinea, Malaysia, Surinam, Mexico, Japan, China, and several countries in Africa were easily differentiated based on an array of 4 to 14 PCR products ranging in size from 200 to 900 bp. Numerical analysis of the banding patterns suggested a close evolutionary link between M. ulcerans isolates from Africa and southeast Asia. The application of 2426 PCR to total DNA, extracted directly from M. ulcerans-infected tissue specimens without culture, demonstrated the sensitivity and specificity of this method and confirmed for the first time that both animal and human isolates from areas of endemicity in southeast Australia have the same genotype.
    MeSH terms: DNA Transposable Elements*; Genotype; Humans; Mycobacterium Infections, Nontuberculous/microbiology*; Sensitivity and Specificity; Polymerase Chain Reaction/methods*; Mycobacterium ulcerans/classification*; Mycobacterium ulcerans/genetics
  3. Choo J, Pang E, Prociv P
    Trans R Soc Trop Med Hyg, 2000 4 5;94(1):21-2.
    PMID: 10748891
    MeSH terms: Ancylostomatoidea*; Ancylostomiasis/epidemiology; Ancylostomiasis/veterinary*; Animals; Disease Vectors*; Dog Diseases/parasitology*; Dogs; Female; Malaysia/epidemiology; Male; Prevalence
  4. Lee WS
    J Pediatr Gastroenterol Nutr, 2000 Mar;30(3):241-5.
    PMID: 10749405
    MeSH terms: Asia, Southeastern/epidemiology; Bacterial Infections/drug therapy; Child, Preschool; Diarrhea/epidemiology; Diarrhea/virology; Drug Resistance, Microbial; Humans; Infant; Infant, Newborn; Rotavirus Infections/epidemiology; Rotavirus Infections/prevention & control; Drug Resistance, Multiple
  5. Lee CY, Hemingway J, Yap HH, Chong NL
    Med Vet Entomol, 2000 Mar;14(1):11-8.
    PMID: 10759307
    The possible insecticide resistance mechanisms of four Malaysian field-collected strains of the German cockroach, Blattella germanica (Linnaeus) (Dictyoptera: Blattellidae), were characterized with biochemical assays and native polyacrylamide gel electrophoresis (PAGE). Elevated esterase activity (at low to moderate frequency) and altered acetylcholinesterase (low frequency) were detected in all field strains, while elevated glutathione S-transferase levels were present in only two strains. Seven esterase bands were separated by native PAGE; a greater intensity occurred in three bands in the resistant strains compared to the susceptible strain. Inhibition studies using specific inhibitors on polyacrylamide gels suggested that the slowest of these three esterases is a cholinesterase, while the other two are carboxylesterases with a preference for beta- over alpha-naphthyl acetate.
    MeSH terms: Acetylcholinesterase/metabolism; Animals; Electrophoresis, Polyacrylamide Gel/veterinary; Esterases/metabolism; Glutathione Transferase/metabolism; Insect Control; Insecticide Resistance*; Malaysia; Male; Blattellidae/enzymology*
  6. Boey C, Yap S, Goh KL
    J Paediatr Child Health, 2000 Apr;36(2):114-6.
    PMID: 10760006
    OBJECTIVE: To determine the prevalence of recurrent abdominal pain (RAP) among Malaysian school children aged from 11 to 16 years.

    METHODOLOGY: A preliminary cross-sectional survey in which three urban schools and three rural schools were selected randomly. Two classes were selected randomly from each year. A questionnaire was given to each child asking him or her about whether they had experienced abdominal pain occurring at least three times over a period of at least 3 months, interfering with normal daily activity. 1 Interfering with normal daily activity was defined as missing school and/or having to stop doing a routine daily activity on account of the pain. Girls whose pains were related to periods were excluded. After the forms had been completed, each child was again interviewed to ensure that Apley's criteria1 was fulfilled in cases of RAP.

    RESULTS: The overall prevalence of RAP among 1549 schoolchildren (764 boys; 785 girls) was 10.2% (95% confidence interval (CI), 8.8-11.8). There appeared to be a higher prevalence in rural schoolchildren (P = 0.008; odds ratio (OR) 1.58), in those with a lower family income (P < 0.001; OR 2.02) and in children whose fathers have a lower educational attainment (P = 0.002; OR 1. 92). There were no significant differences in the prevalence of RAP among children of different sex, age, ethnic group and family size.

    CONCLUSION: : In spite of differences in time and culture, the overall prevalence of 10.2% found in this study is similar to that determined by Apley.1 There are significant differences in the prevalence of RAP between children from rural and urban schools, among children with different family incomes and among children whose parents have different educational backgrounds.

    MeSH terms: Adolescent; Child; Cross-Sectional Studies; Female; Humans; Interviews as Topic; Malaysia; Male; Surveys and Questionnaires; Recurrence; Abdominal Pain/epidemiology*; Prevalence
  7. George J, Saw KY, Ramlan AA, Packya N, Tan AH, Paul G
    Australas Radiol, 2000 Feb;44(1):19-22.
    PMID: 10761254
    In an arthroscopic-MRI correlation study of acute injuries to the knee it was found that anterolateral meniscocapsular separations of the lateral aspect of the knee were missed on MRI reporting. Eighty sports-related injuries of the knee were seen by experienced orthopaedic surgeons at the University of Malaya Medical Centre and at the National Sports Centre, Malaysia from January 1996 to July 1997. Fifty of the patients were suspected to have meniscal tears that were either lateral or medial on clinical examination and they were sent for MRI. Many of these patients were tertiary referrals. Magnetic resonance imaging examinations in 27 of the 50 patients were reported as not showing any intrasubstance or obvious meniscocapsular tears, but arthroscopy performed on them revealed anterolateral meniscocapsular tears of the lateral meniscus of varying degrees in nine of these patients. In retrospect the tears could be seen on MRI, and a pattern to the tears was noted and classified as follows. Type 0, normal; type 1, torn inferior or superior meniscocapsular attachment; type 2, both meniscofemoral and meniscotibial ligaments torn but with minimal separation of meniscus and capsule by fluid or synovitis; and type 3, marked separation of meniscus and capsule by fluid (> 3 mm). Ten patients who did not undergo arthroscopy for various personal and financial reasons underwent MRI which showed type 1 and type 2 tears, and were treated conservatively. These patients were all asymptomatic after 4-6 weeks with regard to clinical signs, suggesting a lateral meniscal tear. Magnetic resonance imaging therefore does reveal minor degrees of meniscocapsular tears anterolaterally when one understands the normal anatomy in this region.
    MeSH terms: Arthroscopy; Athletic Injuries/diagnosis; Humans; Knee Injuries/classification; Knee Injuries/diagnosis*; Magnetic Resonance Imaging; Tibial Meniscus Injuries*
  8. Goh KL, Chang CS, Fock KM, Ke M, Park HJ, Lam SK
    J Gastroenterol Hepatol, 2000 Mar;15(3):230-8.
    PMID: 10764021
    Gastro-oesophageal reflux disease (GORD) occurs more frequently in Europe and North America than in Asia but its prevalence is now increasing in many Asian countries. Many reasons have been given for the lower prevalence of GORD in Asia. Low dietary fat and genetically determined factors, such as body mass index and maximal acid output, may be important. Other dietary factors appear to be less relevant. Increased intake of carbonated drinks or aggravating medicines may influence the increasing rates of GORD in some Asian countries but no strong evidence links other factors, such as the age of the population, smoking or alcohol consumption, to GORD. The management of GORD in Asia is similar to that in Europe and North America but the lower incidence of severe oesophagitis in Asia may alter the approach slightly. Also, because Asians tend to develop stomach cancer at an earlier age, endoscopy is used routinely at an earlier stage of investigation. Gastro-oesophageal reflux disease is essentially a motility disorder, so short-term management of the disease can usually be achieved using prokinetic agents (or histamine (H2)-receptor antagonists). More severe and recurrent GORD may require proton pump inhibitors (PPI) or a combination of prokinetic agents and PPI. The choice of long-term treatment may be influenced by the relative costs of prokinetic agents and PPI.
    MeSH terms: Asia/epidemiology; Gastroesophageal Reflux/epidemiology*; Humans; Risk Factors; Incidence; Prevalence
  9. Tan SY
    Kidney Blood Press Res, 2000;23(2):138-42.
    PMID: 10765117 DOI: 10.1159/000025967
    FcgammaRIIs are the most widely distributed of the Fcgamma receptor family and play an important role in the clearance of immune complexes. Evidence that the FcgammaRIIa-R131 allotype is less able to process and clear immune complexes effectively suggests that this may be a disease susceptibility factor for systemic lupus erythematosus (SLE). Data from studies published thus far do not agree on the potential role of FcgammaRIIa polymorphism in the genetics of SLE. Most studies in fact show no evidence for any correlation between polymorphism of FcgammaRIIa and risk for SLE. However, it remains to be determined whether FcgammaRIIa polymorphism may play a critical role in certain groups of patients, especially in those of differing ethnic background. Polymorphism of FcgammaRIIa may also be important in determining disease phenotype, and identification of this influence may have important implications in patient care and in identifying patients for more aggressive therapy.
    MeSH terms: Humans; Lupus Erythematosus, Systemic/genetics*; Lupus Nephritis/genetics*; Polymorphism, Genetic/genetics*; Antigens, CD/genetics*; Receptors, IgG/genetics*
  10. Shirako Y, Yamaguchi Y
    J Gen Virol, 2000 May;81(Pt 5):1353-60.
    PMID: 10769079
    Sagiyama virus (SAG) is a member of the genus Alphavirus in the family Togaviridae, isolated in Japan from mosquitoes in 1956. We determined the complete nucleotide sequence of the SAG genomic RNA from the original stock virus which formed a mixture of plaques with different sizes, and that from a full-length cDNA clone, pSAG2, infectious RNA transcripts from which formed uniform large plaques on BHK-21 cells. The SAG genome was 11698 nt in length exclusive of the 3' poly(A) tail. Between the complete nucleotide sequences of the full-length cDNA clone, pSAG2, and the consensus sequence from the original stock virus, there were nine amino acid differences; two each in nsP1, nsP2 and E1, and three in E2, some of which may be responsible for plaque phenotypic variants in the original virus stock. SAG was most closely related to Ross River virus among other alphaviruses fully sequenced, with amino acid sequence identities of 86% in the nonstructural proteins and of 83% in the structural proteins. The 3' terminal 280 nt region of SAG was 82% identical to that of Barmah Forest virus, which was otherwise not closely related to SAG. Comparison of the nucleotide sequence of SAG with partial nucleotide sequences of Getah virus (GET), which was originally isolated in Malaysia in 1955 and is closely related to SAG in serology and in biology, showed near identity between the two viruses, suggesting that SAG is a strain of GET.
    MeSH terms: Aedes/virology; Alphavirus/classification*; Alphavirus/genetics*; Alphavirus/physiology; Animals; Base Sequence; Cells, Cultured; Chickens; Cloning, Molecular; Cricetinae; Molecular Sequence Data; Viral Plaque Assay; DNA-Directed RNA Polymerases*; RNA, Viral/genetics; Genetic Variation; Viral Envelope Proteins/genetics; Genome, Viral*; Viral Nonstructural Proteins/genetics; Sequence Analysis, DNA; DNA, Complementary; Alphavirus Infections/virology
  11. Peh KK, Wong CF, Yuen KH
    Drug Dev Ind Pharm, 2000 Apr;26(4):447-50.
    PMID: 10769787
    Lipophilicity was evaluated as a possible mechanism for drug retardation from a glyceryl monostearate matrix system. Lipophilicity of the glyceryl monostearate matrix system was studied using contact angle measurement of water droplets on the surface of compressed disks, extrudate ascension of water, and movement of water through a powder mixture packed in a high-performance liquid chromatographic (HPLC) column. Increase in glyceryl monostearate content resulted in an increase in water droplet contact angle, decrease in the rate of water ascending the extrudate, and increase in the pressure values as a function of flow rate of water moving through the powder mixture. These could be due to the increase in lipophilicity of the matrix, rendering the matrix less wettable. As a result, the rate of water penetration into the matrix decreased, and the drug release could be sustained.
    MeSH terms: Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Delayed-Action Preparations*; Glycerides/pharmacokinetics*; Glycerides/chemistry; Powders; Water
  12. Bidawid S, Farber JM, Sattar SA, Hayward S
    J Food Prot, 2000 Apr;63(4):522-8.
    PMID: 10772219
    Experiments were performed to determine the thermal resistance of hepatitis A virus (HAV) in three types of dairy products containing increased amounts of fat content (skim milk, homogenized milk; 3.5% MFG, and table cream; 18% MFG). HAV-inoculated dairy products were introduced into custom-made U-shaped microcapillary tubes that in turn were simultaneously immersed in a waterbath, using custom-made floating boats and a carrying platform. Following exposure to the desired time and temperature combinations, the contents of each of the tubes was retrieved and was tested by plaque assay to determine the reduction in virus titer. Our data indicated that < 0.5 min at 85 degrees C was sufficient to cause a 5-log reduction in HAV titer in all three dairy products, whereas at 80 degrees C, < or = 0.68 min (for skim and homogenized milk), and 1.24 min (for cream) were needed to cause a similar log reduction. Using a nonlinear two-phase negative exponential model (two-compartment model) to analyze the data, it was found that at temperatures of 65, 67, 69, 71, and 75 degrees C, significantly (P < 0.05) higher exposure times were needed to achieve a 1-log reduction in virus titer in cream, as compared to skim and homogenized milk. For example, at 71 degrees C, a significantly (P < 0.05) higher exposure time of 0.52 min (for cream) was needed as compared to < or = 0.18 min (for skim and homogenized milk) to achieve a 1-log reduction in virus titer. A similar trend of inactivation was observed at 73 and 75 degrees C where significantly (P < 0.05) higher exposure times of 0.29 to 0.36 min for cream were needed to cause a 1-log reduction in HAV in cream, as compared to < or = 0.17 min for skim and homogenized milk. This study has provided information on the heat resistance of HAV in skim milk, homogenized milk, and table cream and demonstrated that an increase in fat content appears to play a protective role and contributes to the heat stability of HAV.
    MeSH terms: Animals; Dairy Products/microbiology*; Dietary Fats; Food Microbiology*; Hot Temperature*; Hepatovirus*; Time Factors
  13. Bis
    Razak IA, Raj SS, Fun HK, Tong YX, Lu ZL, Kang BS
    Acta Crystallogr C, 2000 Mar;56 (Pt 3):291-2.
    PMID: 10777923
  14. Hisham AN, Aina EN
    Aust N Z J Surg, 2000 Apr;70(4):251-3.
    PMID: 10779054
    BACKGROUND: The Zuckerkandl's tubercle (ZT) of the thyroid gland is a well-described anatomical landmark, but few studies have clearly defined its association with pressure symptoms.

    METHODS: Sixty-six consecutive patients who had primary thyroid surgery were prospectively included in the present study between late January and early August 1998.

    RESULTS: A total of 96 capsular dissections were performed at thyroid surgery. Grades two and three ZT were recognized in 77 (80.2%) dissections. In general 49 (63.6%) of them were associated with significant pressure symptoms. In 43 (87.8%) of the dissections with pressure symptoms, grade 3 ZT was observed (mean weight of goitre: 154.8 g). Interestingly in this group, 16 (37.2%) patients with pressure symptoms had a goitre that was < 100 g and in one patient it was only 21 g.

    CONCLUSIONS: The pressure symptom of the thyroid gland does not always appear to be due to the large size of the goitre. In a relatively small-size goitre the ZT may cause significant pressure symptoms. Observations in the present study supported a strong association of enlarged ZT with pressure symptoms. We believe this is unlikely to be simply a coincidence but rather a consequence of the enlarged tubercle. Nonetheless a prospective randomized study is called for to allow meaningful and objective evidence to be drawn.

    MeSH terms: Adolescent; Adult; Aged; Female; Goiter/pathology; Humans; Male; Middle Aged; Parathyroid Glands/anatomy & histology; Postoperative Complications; Pressure; Prospective Studies; Recurrent Laryngeal Nerve/anatomy & histology; Thyroid Gland/anatomy & histology*; Thyroid Gland/pathology; Thyroidectomy
  15. Al-Haddawi MH, Jasni S, Zamri-Saad M, Mutalib AR, Zulkifli I, Son R, et al.
    Vet J, 2000 May;159(3):274-81.
    PMID: 10775473
    In vitro experiments were undertaken to study the adhesion and colonization to tracheal mucosa, lung and aorta explants from freshly killed rabbits of two different strains of Pasteurella multocida. Serotype A:3 (capsulated, fimbriae +, haemagglutination -, dermonecrotic toxin -) isolated from a rabbit with rhinitis, and serotype D:1 (non-capsulated, fimbriae +, haemagglutination +, dermonecrotic toxin +) isolated from a dead rabbit with septicaemia, were used. When the explants were observed under the scanning electron microscope, the type D strain was highly adherent to trachea and aorta explants compared to the type A strain. Adhesion to lung explants was best achieved by the type A strain after 45 min incubation, but after 2 h incubation no significant difference was observed between the strains. Our data indicate that the presence of fimbriae and the absence of capsule seem to enhance the adherence of P. multocida type D strain to tracheal tissue. The capsular material of P. multocida type A strain and the toxin of the type D strain seem to influence the adherence to lung tissue in rabbit. Adhesion of strain D to aorta may indicate the expression of receptors on the endothelium to that strain and may also explain the ability of certain strains to cause septicaemia.
    MeSH terms: Animals; Aorta/microbiology; Aorta/ultrastructure; Bacterial Adhesion*; Dermotoxins/metabolism; Erythrocytes/microbiology; Humans; Lung/microbiology; Lung/ultrastructure; Microscopy, Electron, Scanning; Pasteurella Infections/microbiology; Pasteurella Infections/veterinary*; Rabbits/microbiology*; Trachea/microbiology; Trachea/ultrastructure; Virulence; Pasteurella multocida/classification; Pasteurella multocida/pathogenicity; Pasteurella multocida/physiology*; Culture Techniques
  16. Lim JM, Hong AG, Raman S, Shyamala N
    Ultrasound Obstet Gynecol, 2000 Feb;15(2):131-7.
    PMID: 10775996
    To determine whether racial differences affect the relationship between the fetal femur diaphysis length and the neonatal crown-heel length.
    MeSH terms: Adolescent; Adult; Anthropometry/methods*; Birth Weight/genetics; China/ethnology; Female; Femur/anatomy & histology*; Femur/ultrasonography*; Fetus/anatomy & histology*; Humans; India/ethnology; Malaysia/ethnology; Male; Predictive Value of Tests; Pregnancy; Prospective Studies; Reproducibility of Results; Bias (Epidemiology); Linear Models; Least-Squares Analysis; Ultrasonography, Prenatal/methods*; Crown-Rump Length*; European Continental Ancestry Group/genetics*; Asian Continental Ancestry Group/genetics*
  17. Du Boulay D, Shaari K, Skelton BW, Waterman PG, White AH
    Acta Crystallogr C, 2000 Feb;56 ( Pt 2):199-200.
    PMID: 10777886
    MeSH terms: Malaysia; Models, Molecular; Molecular Conformation; Plants, Medicinal/chemistry*; Podophyllotoxin/analogs & derivatives*; Podophyllotoxin/chemistry; Singapore; Crystallography, X-Ray
  18. Manshor AT, Kamalanabhan TJ
    Psychol Rep, 2000 Feb;86(1):203-14.
    PMID: 10778271
    This paper examined the raters' and the ratees' preferences in Malaysia regarding the performance appraisal process and feedback. A total of 52 managers (raters) and 122 subordinates (ratees) participated. Analysis by t test and correlation showed significant differences between raters and the ratees on most factors. Ratees preferred to have more frequent appraisals than once a year and preferred to have more frequent feedback from the managers about their performance. Ratees' preference for the purpose of information on performance was towards salary increase, promotion, training, and career development whereas the raters gave more importance to training and career development.
    MeSH terms: Adult; Attitude*; Employee Performance Appraisal*; Ethnic Groups/psychology*; Feedback*; Female; Humans; Malaysia; Male; Personnel Management
  19. Goh KJ, Tan CT, Chew NK, Tan PS, Kamarulzaman A, Sarji SA, et al.
    N Engl J Med, 2000 Apr 27;342(17):1229-35.
    PMID: 10781618 DOI: 10.1056/NEJM200004273421701
    BACKGROUND: Between September 1998 and June 1999, there was an outbreak of severe viral encephalitis due to Nipah virus, a newly discovered paramyxovirus, in Malaysia.
    METHODS: We studied the clinical features of the patients with Nipah virus encephalitis who were admitted to a medical center in Kuala Lumpur. The case definition was based on epidemiologic, clinical, cerebrospinal fluid, and neuroimaging findings.
    RESULTS: Ninety-four patients with Nipah virus infection were seen from February to June 1999 (mean age, 37 years; ratio of male patients to female patients, 4.5 to 1). Ninety-three percent had had direct contact with pigs, usually in the two weeks before the onset of illness, suggesting that there was direct viral transmission from pigs to humans and a short incubation period. The main presenting features were fever, headache, dizziness, and vomiting. Fifty-two patients (55 percent) had a reduced level of consciousness and prominent brain-stem dysfunction. Distinctive clinical signs included segmental myoclonus, areflexia and hypotonia, hypertension, and tachycardia and thus suggest the involvement of the brain stem and the upper cervical spinal cord. The initial cerebrospinal fluid findings were abnormal in 75 percent of patients. Antibodies against Hendra virus were detected in serum or cerebrospinal fluid in 76 percent of 83 patients tested. Thirty patients (32 percent) died after rapid deterioration in their condition. An abnormal doll's-eye reflex and tachycardia were factors associated with a poor prognosis. Death was probably due to severe brain-stem involvement. Neurologic relapse occurred after initially mild disease in three patients. Fifty patients (53 percent) recovered fully, and 14 (15 percent) had persistent neurologic deficits.
    CONCLUSIONS: Nipah virus causes a severe, rapidly progressive encephalitis with a high mortality rate and features that suggest involvement of the brain stem. The infection is associated with recent contact with pigs.
    MeSH terms: Adult; Animals; Animal Husbandry; Antibodies, Viral/blood; Antibodies, Viral/cerebrospinal fluid; Cerebrospinal Fluid/immunology; Cerebrospinal Fluid/chemistry; Electroencephalography; Female; Humans; Magnetic Resonance Imaging; Malaysia/epidemiology; Male; Nervous System Diseases/etiology; Recurrence; Swine; Logistic Models; Paramyxoviridae Infections/complications; Paramyxoviridae Infections/mortality; Paramyxoviridae Infections/epidemiology; Paramyxoviridae Infections/physiopathology*; Encephalitis, Viral/mortality; Encephalitis, Viral/epidemiology; Encephalitis, Viral/physiopathology; Encephalitis, Viral/virology*
  20. Siar CH, Ng KH
    Br J Oral Maxillofac Surg, 2000 Feb;38(1):19-22.
    PMID: 10783442
    Analysis of case records of 46 patients with peripheral odontogenic fibroma (1967-95) diagnosed in the Division of Stomatology, Institute for Medical Research, Kuala Lumpur, disclosed a relatively young age of onset (mean, 32.2 years; range 5 months-64 years; peak incidence second decade of life), a slight female preponderance (M:F ratio 1:1.3), no racial predilection, a slight bias towards location in the mandible (52%) and a wide histomorphological range. All cases were treated by simple excision. Follow-up records were generally not available, so we do not know what the recurrence rate is.
    MeSH terms: Adolescent; Adult; Animals; Child; Child, Preschool; Ethnic Groups; Female; Humans; Infant; Jaw Neoplasms/epidemiology; Jaw Neoplasms/pathology*; Malaysia/epidemiology; Male; Middle Aged; Odontogenic Tumors/epidemiology; Odontogenic Tumors/pathology*; Sex Ratio; Age of Onset
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