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Fulltext Crystal structure and Hirshfeld surface analysis of a chalcone derivative: (E)-3-(4-fluoro-phen-yl)-1-(4-nitro-phen-yl)prop-2-en-1-one

Wong QA, Chia TS, Kwong HC, Chidan Kumar CS, Quah CK, Arafath MA

Acta Crystallogr E Crystallogr Commun, 2019 Jan 01;75(Pt 1):53-57.
PMID: 30713733 DOI: 10.1107/S2056989018017450

The mol-ecular structure of the title chalcone derivative, C15H10FNO3, is nearly planar and the mol-ecule adopts a trans configuration with respect to the C=C double bond. The nitro group is nearly coplanar with the attached benzene ring, which is nearly parallel to the second benzene ring. In the crystal, mol-ecules are connected by pairs of weak inter-molecular C-H⋯O hydrogen bonds into inversion dimers. The dimers are further linked by another C-H⋯O hydrogen bond and a C-H⋯F hydrogen bond into sheets parallel to (104). π-π inter-actions occur between the sheets, with a centroid-centroid distance of 3.8860 (11) Å. Hirshfeld surface analysis was used to investigate and qu-antify the inter-molecular inter-actions.

Matched MeSH terms: Transsexualism
Fulltext Gender identity disorder is not simply two in one

Syed Masroor, A., Abdul Ghani, K.

International Medical Journal Malaysia, 2013;12(2):83-85.
MyJurnal

A Case Report on Gender Identity Disorder with Recurrent Depressive Disorder is presented. Individuals having this disorder often exhibit discomfort about their actual anatomic gender, and they may have wished to alter their bodies. Sex role-stereotypes adopted during childhood are the beliefs, characteristics and behaviors of individual cultures that are considered normal and appropriate for boys and girls to possess. These "norms" are influenced by one's family and friends, the mass-media, and their community. Since some cultures disapprove of cross-gender behavior, it often results in significant problems for affected individuals and those in close relationships with them. The importance of treatment is not only because of the high rate of mental-health problems, including Depression but with higher suicide rate among untreated transsexual people than in the general population. These problems are not usually related to the gender identity issues themselves, but the social and cultural responses to gender-deviated individuals. An example which classically illustrates Gender Identity Disorder is the case of a young man from Brunei Darussalam, who was seen and treated. This
contribution will highlight the cultural and religious perspective of this Disorder.

Matched MeSH terms: Transsexualism
Sex reassignment technology: the dilemma of transsexuals in Islam and Christianity

Ishak MS, Haneef SS

J Relig Health, 2014 Apr;53(2):520-37.
PMID: 23187616 DOI: 10.1007/s10943-012-9656-z

The birth of people with confused or ambiguous sex makeup as a biological fact since the annals of history has posed the challenge of accommodating them within the binary gender of sociocultural systems. In this process, the role of religion as a defining factor in social engineering has been paramount. Major religions, such as Islam and Christianity, have addressed this issue within the frame of their God-ordained laws by devising a set of moral and legal imperatives specific to the "third gender." Modern developments in medicine and biology, however, have made sex reassignment possible for this category of people, today called transsexuals. The question is: How do Islam and Christianity respond to it. After presenting an analytical view of both Muslim scholars and Christian religious authorities on the legitimacy of sex reassignment for transsexuals, this paper attempts to explore if such a dilemma can be resolved.

Matched MeSH terms: Transsexualism/psychology
Penile prosthesis implantation in a transsexual neophallus

Tan HM

Asian J Androl, 2000 Dec;2(4):304-6.
PMID: 11202422

Reconstruction surgery for a female to male transsexual usually involves mastectomy, hysterectomy and creating an aesthetically appealing neophallus. We have successfully inserted an inflatable prosthesis using the AMS CX prosthesis in a 45 year old transsexual, who had a large bulky neophallus constructed from the anterior abdominal subcutaneous fat, about 9 years ago. The single cylinder CX prosthesis was well anchored to the symphysis pubis using a dacron windsock tubing, the activation pump was placed in the dependent pouch of the right labium and the reservior in the usual perivesical space. The patient subsequently had debulking procedure using liposuction to create a more aesthetic and functional phallus. To date, the inflatable neophallus prosthesis is functioning well.

Matched MeSH terms: Transsexualism/surgery*
Fulltext Factors Associated with Medical Doctors' Intentions to Discriminate Against Transgender Patients in Kuala Lumpur, Malaysia

Vijay A, Earnshaw VA, Tee YC, Pillai V, White Hughto JM, Clark K, et al.

LGBT Health, 2018 01;5(1):61-68.
PMID: 29227183 DOI: 10.1089/lgbt.2017.0092

PURPOSE: Transgender people are frequent targets of discrimination. Discrimination against transgender people in the context of healthcare can lead to poor health outcomes and facilitate the growth of health disparities. This study explores factors associated with medical doctors' intentions to discriminate against transgender people in Malaysia.
METHODS: A total of 436 physicians at two major university medical centers in Kuala Lumpur, Malaysia, completed an online survey. Sociodemographic characteristics, stigma-related constructs, and intentions to discriminate against transgender people were measured. Bivariate and multivariate linear regression were used to evaluate independent covariates of discrimination intent.
RESULTS: Medical doctors who felt more fearful of transgender people and more personal shame associated with transgender people expressed greater intention to discriminate against transgender people, whereas doctors who endorsed the belief that transgender people deserve good care reported lower discrimination intent. Stigma-related constructs accounted for 42% of the variance and 8% was accounted for by sociodemographic characteristics.
CONCLUSIONS: Constructs associated with transgender stigma play an important role in medical doctors' intentions to discriminate against transgender patients. Development of interventions to improve medical doctors' knowledge about and attitudes toward transgender people are necessary to reduce discriminatory intent in healthcare settings.

Matched MeSH terms: Transsexualism/psychology
Fulltext Methamphetamine abuse in sexual minorities: a case report

Lai, M.H., Norliza, C.M., Marhani, M.

Malaysian Journal of Psychiatry, 2012;21(2):57-60.
MyJurnal

Methamphetamine production and abuse increased significantly in Malaysia. Lesbian, gay, bisexual and transgender (LGBT) populations have higher prevalence of substance abuse compared to general population. Their unmet needs pose greater challenges in managing their substance related disorders. This paper described the agony of a Malaysian lesbian with gender identity disorder who abused substances and developed amphetamine-induced psychosis. Her sexual identity issue was explored in managing her substance related disorders to improve her outcome.

Matched MeSH terms: Transsexualism
Biological and psychological influences of cross sex hormone in transgender

Ling LS, Sidi H, Lope RAR, Das S, Baharudin A

Curr Drug Targets, 2018 May 11.
PMID: 29749310 DOI: 10.2174/1389450119666180511161420

Transgender is a complex state of bio-psycho-social dimension of human sexuality. It encompasses cognitive-emotional-behavior component that makes the person unique in his or her sexual expression. Transgender tend to use cross sex hormone in order to eradicate their secondary sexual characteristics and to facilitate the shift to their experienced gender. The common masculinising sex hormone use, i.e. Female to Male Treatment Options (FMTO) is testosterone and for feminising hormone i.e. Male to Female Treatment Options (MFTO) is a combination of estrogen with anti-androgen, respectively. Cross sex hormone, i.e. FMTO, or MFTO has biological and psychological influences on the transgender individuals. Nevertheless, cross sex hormone may also poses a range of side effect profiles, varies from the biological to psychosocial impact. The psychological impact can be paramount until it causes severe mental-health problems and even suicide. Numerous ranges of bio-psycho-social influence of cross-sex hormone were highlighted in this review as fundamental core knowledge in the art to know practice when dealing with the treatment options. In psychiatry, the change in the biological appearance may have great influence in the transgender individual, especially in the context of psychosocial and cultural perspective.

Matched MeSH terms: Transsexualism
HIV-related needs for safety among male-to-female transsexuals (mak nyah) in Malaysia

Koon Teh Y

SAHARA J, 2008 Dec;5(4):178-85.
PMID: 19194599

This research, commissioned by the Malaysian AIDS Council in 2007, is qualitative and descriptive in nature. In depth face-to-face interviews were carried out with 15 mak nyah respondents from five major towns. The interviews were guided by an interview schedule that had seven main topics: brief background; hormone-taking behaviour; safe sex; health care; substance abuse; harassment from authorities; and HIV prevention. The HIV problem among the mak nyah, mak nyah sex workers and their clients is critical. Many do not have in-depth HIV/AIDS knowledge and do not practise safe sex. The problem gets worse when most mak nyah do not consider HIV/AIDS as a primary concern because of other pressing problems like employment and discrimination. There are also no HIV prevention activities in many parts of Malaysia. Mak nyah also face constant harassment from enforcement authorities for prostitution. This hampers HIV prevention work.

Matched MeSH terms: Transsexualism*
Fulltext Psycho-social and spiritual backgrounds, experiences, and needs as a transsexual: a qualitative study within Persatuan Insaf Pahang

Drama, S., Maliya, S., Liyana, A., Farhani, S., Jannah, R., Razman., M.R.

International Medical Journal Malaysia, 2016;15(2):27-36.
MyJurnal

Introduction: Transsexuals face discriminations and rejections from the Malaysian society. The number of
studies done on understanding the phenomenology, experiences, and problems faced by transsexuals is still
few in Malaysia. This research aims to document their psycho-social and spiritual backgrounds and the
relevant experiences, and to explore their perceptions and needs as male-to-female transsexuals in the
context of Persatuan Insaf Pahang, Malaysia. Materials and Methods: A qualitative research was carried out
in July and August 2015 among eight male-to-female transsexual adults in Kuantan, Pahang. Snowball
sampling was used. Participants who gave consent were interviewed in two focus groups. Data obtained was
transcribed and used as the primary data source. Results: Subjects in this study reported confusions over
their gender identity since childhood. They struggled against conflicts regarding their transsexuality in
adolescence, and eventually many quit their studies. As adults, they were discriminated against in
employment and religious settings. They provided positive feedbacks on religious authorities who could
understand problems unique to transsexuals and empathise with the transsexual community. Conclusion: The
psycho-sexual phenomenology is the same in transsexuals all over the world. Misunderstanding and
discrimination from the society remain heavy towards this community. Transsexuals should learn to adapt to
meeting expectations from the society as well, so they could be accepted in public. They will need religious
guidance and spiritual support for better quality of life. Dedicated efforts are still needed in training
professionals in the educational, medical, and religious fields to attend to the specific needs of transsexuals
in this country.

Matched MeSH terms: Transsexualism