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Aspects of obstetrical defibrination in West Malaysia

White JC, Chan LK, Lau KS, Sen DK

J Trop Med Hyg, 1976 Jun;79(6):132-6.

Five patients illustrate various aspects of obstetrical defibrination in West Malaysia, resulting from exaggeration of changes in fibrinolytic-coagulation equilibrium that occur at delivery. Hypofibrinogenaemia and fibrinolysis may occur in association or either feature predominate. These patients are from a population in which a variety of genetic and environmental factors may interact, e.g. abnormal haemoglobins, cold agglutinins, viral and other infections, introducing additional complications.

Matched MeSH terms: Pregnancy Complications, Hematologic/blood*

Haemoglobin E variants and pregnancy in Malaysian aborigines

Ong HC

Acta Haematol., 1974;52(4):220-2.

PMID: 4217527 DOI: 10.1159/000208244

Haemoglobin E complicates 22.2°/o of pregnancy in Malaysian aborigines, the prevalence of variants associated with pregnancy being, 15.8% with Hb E trait abnormality, 3.9% with Hb E homozygous disease, and 2.5% with Hb E thalassaemia disease. Minor haematological abnormalities occur with the trait and homozygous conditions, though a more unfavourable response is expected with Hb E thalassaemia. Haemolysis is not a prominent feature and it is suggested that factors other than the haemoglobinopathic state
probably accounts for any unfavourable response in pregnancy.
Key Words: Haemoglobin E; Haemoglobinopathies; Haemolytic anaemias; Hb E thalassaemia; Malaysia; Pregnancy
Study site: Hospital Orang Asli, Gombak, Selangor, Malaysia

Matched MeSH terms: Pregnancy Complications, Hematologic/blood*

Southeast asian ovalocytosis: the need for a carefull observation of red cell indices and blood smear

Moulin PA, Nivaggioni V, Saut N, Grosdidier C, Bernot D, Baccini V

Ann. Biol. Clin. (Paris), 2017 Dec 01;75(6):699-702.

PMID: 29043981 DOI: 10.1684/abc.2017.1291

Southeast asian ovalocytosis (SAO) is characterized by macro-ovalocytes and ovalo-stomatocytes on blood smear. SAO is common in Malaisia and Papua-New-Guinea where upwards to 40 per cent of the population is affected in some coastal region. Inherited in an autosomal dominant way, illness results from deletion of codons 400-408 in SLC4A1 gene which encodes for band 3 erythrocyte membrane protein. This deletion is responsible for an unusual erythrocyte stiffness and oval shape of the cells on blood smear. Heterozygous carriers are usually asymptomatic whereas homozygous are not viable without an intensive antenatal care. Here, we describe 4 patients diagnosed incidentally by cytogram appearance of the Advia® 2120i (Siemens) representing hemoglobin concentration according to red blood mean cellular volume (GR/VCH).

Matched MeSH terms: Pregnancy Complications, Hematologic/blood

Fulltext Anemia and iron status of Malay women attending an antenatal clinic in Kubang Kerian, Kelantan, Malaysia

Hassan R, Abdullah WZ, Nik Hussain NH

Southeast Asian J Trop Med Public Health, 2005 Sep;36(5):1304-7.

PMID: 16438162

The purpose of this study was to detect the frequency of iron deficiency anemia in women attending their first antenatal clinic at a Maternal and Child Health Clinic in Kubang Kerian, a district of Kelantan that is located on the East coast of Malaysia. A cross-sectional study was done over a two-month period and fifty-two Malay women were enrolled in this study. Red blood cell indices and serum ferritin were used as a screening tool for anemia and iron status. Eighteen patients (34.6%) were anemic. The majority were classified as having mild anemia (90%). Four of them had hypochromic microcytic anemia. Of 52 women, 7 had iron deficient erythropoiesis and 11 (61.1%) had iron deficient anemia. The prevalence of iron deficiency anemia in pregnant women was 21.2%, which is similar to other developing countries. The serum ferritin level was significantly associated with the hemoglobin level (p=0.003). Other red blood cell indices were not useful in predicting iron deficient erythropoiesis. It is important to detect iron deficient erythropoiesis during the first antenatal check-up, as it is an early manifestation of iron deficiency anemia. In conclusion, screening for iron deficient is recommended during first antenatal visit because iron deficiency anemia is still the leading cause of nutritional deficiency in pregnant women. This will initiate an early therapeutic intervention so as to reduce public health problem.
Study site: Hopital Universiti Sains Malaysia (HUSM) and the Maternal and Child Health Clinic, Kubang Kerian, Kelantan, Malaysia

Matched MeSH terms: Pregnancy Complications, Hematologic/blood

Anaemia and folate status in late pregnancy in a mixed Asiatic population

Hibbard BM, Hibbard ED

J Obstet Gynaecol Br Commonw, 1972 Jul;79(7):584-91.

PMID: 5043421

Matched MeSH terms: Pregnancy Complications, Hematologic/blood*

Comparison between Iberet Folic® and Zincofer® in treatment of iron deficiency anaemia in pregnancy

Abu MA, Borhan AS, Abdul Karim AK, Ahmad MF, Mahdy ZA

Horm Mol Biol Clin Investig, 2020 Dec 14;42(1):49-56.

PMID: 33781008 DOI: 10.1515/hmbci-2020-0034

OBJECTIVES: To compare the effect of Iberet Folic® and Zincofer® on haemoglobin (Hb) and serum ferritin level; and its adverse effect.

METHODS: This randomised controlled trial conducted from January 2018 until December 2018. Pregnant women below 34 weeks of gestation, with Hb concentration less than 11 g/dL and serum ferritin level less than 12 ug/L were randomised to receive either one tablet Zincofer® or one tablet Iberet Folate® daily for four weeks. Both groups were compared in terms of effect on Hb level, serum ferritin level, and other haematological indices adverse effect related to treatment, and treatment cost.

RESULTS: Hundred and thirty patients were recruited in this study with 68 patients in Iberet Folic group and 62 patients in Zincofer group. The change in the Hb and serum ferritin level from baseline to day 30 did not differ significantly between treatment groups. The mean (±SD) change from baseline to day 30 was 2.15 (±0.59) g/dL in the Iberet Folic group, and 1.98 (±0.49) in the Zincofer (p value = 0.08). Mean serum ferritin at day 30 was 17.2 (±3.68) ug/L and 16.7 (±4.28) ug/L with 8.44 (±3.41) and 8.55 (±3.50) difference, respectively (p = 0.86). Adverse events were comparable in between groups, with p value >0.05. GI intolerance and constipation were among the common side effects, occurred in 34.6 and 29.2% cases, respectively.

CONCLUSIONS: Zincofer® offers equivalent efficacy and side effect profile in comparison with Iberet Folic® for the treatment of iron deficiency anaemia (IDA) during pregnancy, but with lower cost.

Matched MeSH terms: Pregnancy Complications, Hematologic/blood

Iron deficiency in the tropics

Fleming AF

Clin Haematol, 1982 Jun;11(2):365-88.

PMID: 7042157

Matched MeSH terms: Pregnancy Complications, Hematologic/blood

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