MyMedR

The history, composition, chemistry & pharmacology of the betel-tobacco chew (QUID.)

Lee HT

Dent J Malaysia Singapore, 1973 May;13(1):63-9.

PMID: 4521127

Matched MeSH terms: Periodontal Diseases/etiology

Fulltext Systemic Manifestations of the Periodontal Disease: A Bibliometric Review

Ahmad P, Arshad AI, Della Bella E, Khurshid Z, Stoddart M

Molecules, 2020 Oct 01;25(19).

PMID: 33019648 DOI: 10.3390/molecules25194508

This bibliometric review aimed to identify and analyze the top 100 most-cited publications on the systemic manifestations of periodontal disease (PD). A literature search was performed using the Web of Science (WoS) 'All Databases', without any restriction of language, publication year, or study design. Of 4418 articles, the top 100 were included based on their citation count. After downloading the full texts, their bibliometric information was extracted and analyzed. The citation counts for the top 100 articles ranged from 156 to 4191 (median 217). The most productive years were 2003 and 2005, with 20 articles on the list. Majority of the articles were published in the Journal of Periodontology (n = 25). The top 100 articles were generated primarily from the USA (n = 61). Most of the publications were clinical trials (n = 27) and focused on the cardiovascular manifestations of PD (n = 31). Most of the articles were within the evidence level V (n = 41). A total of 58 studies received funding and the most frequently used keyword in the top articles was "periodontal disease" (n = 39). The current citation analysis presents insights into the current trends in the systemic manifestations of periodontal disease.

Matched MeSH terms: Periodontal Diseases/pathology*

Dysregulation of metallothionein and zinc aggravates periodontal diseases

Aziz J, Rahman MT, Vaithilingam RD

J Trace Elem Med Biol, 2021 Jul;66:126754.

PMID: 33831799 DOI: 10.1016/j.jtemb.2021.126754

BACKGROUND: Periodontitis (PD) is a multifaceted inflammatory disease connected to bacterial infection that results in the destruction of tooth supporting structures and eventually tooth loss. Given their involvement in infection and inflammation, both metallothionein (MT) and zinc (Zn) might play vital roles in the development and progression of PD. More specifically, both MT and Zn are heavily involved in regulating immune functions, controlling bacterial infection, balancing inflammatory responses, and reducing oxidative stress, all of which are associated with the pathogenesis of PD.

OBJECTIVE: This review paper will explore the physiological functions of MT and Zn and hypothesise how dysregulation could negatively affect periodontal health, leading to PD.

FINDINGS: Bacterial lipopolysaccharide (LPS) derived from periodontal pathogens, namely P. gingivalis initiates the acute phase response, thus upregulating the expression of MT which leads to the subsequent deficiency of Zn, a hallmark of periodontal disease. This deficiency leads to ineffective NETosis, increases the permeability of the gingival epithelium, and disrupts the humoral immune response, collectively contributing to PD. In addition, the presence of LPS in Zn deficient conditions favours M1 macrophage polarisation and maturation of dendritic cells, and also inhibits the anti-inflammatory activity of regulatory T cells. Collectively, these observations could theoretically give rise to the chronic inflammation seen in PD.

CONCLUSION: A disrupted MT and Zn homeostasis is expected to exert an adverse impact on periodontal health and contribute to the development and progression of PD.

Matched MeSH terms: Periodontal Diseases/metabolism*

Assessment of periodontal diseases in epidemiological investigations: a critical review

Abdul-Kadir R

Singapore Dent J, 1989 Dec;14(1):6-12.

PMID: 2487478

Like dental caries, epidemiological assessment of periodontal disease is important for purposes of recognizing the extent of the disease in the population as well as a basis for planning and evaluating preventive and treatment programmes. while present day measurement methods for dental caries are excellent such is not true for periodontal diseases. This paper reviews the development and usefulness of different indices for the assessment of periodontal disease and treatment needs in epidemiological investigations.

Matched MeSH terms: Periodontal Diseases/epidemiology*

Proteomic Investigations of In Vitro and In Vivo Models of Periodontal Disease

Binti Badlishah Sham NI, Lewin SD, Grant MM

Proteomics Clin Appl, 2020 05;14(3):e1900043.

PMID: 31419032 DOI: 10.1002/prca.201900043

Proteomics has currently been a developing field in periodontal diseases to obtain protein information of certain samples. Periodontal disease is an inflammatory disorder that attacks the teeth, connective tissues, and alveolar bone within the oral cavity. Proteomics information can provide proteins that are differentially expressed in diseased or healthy samples. This review provides insight into approaches researching single species, multi species, bacteria, non-human, and human models of periodontal disease for proteomics information. The approaches that have been taken include gel electrophoresis and qualitative and quantitative mass spectrometry. This review is carried out by extracting information about in vitro and in vivo studies of proteomics in models of periodontal diseases that have been carried out in the past two decades. The research has concentrated on a relatively small but well-known group of microorganisms. A wide range of models has been reviewed and conclusions across the breadth of these studies are presented in this review.

Matched MeSH terms: Periodontal Diseases/metabolism*

Fulltext Association between smoking and periodontal disease: a review of the literature

Ramli J, Taiyeb Ali TB

Ann Dent, 1999;6(1):21-6.

MyJurnal

The role of smoking as a contributory factor in the progression of the periodontal disease process has long been suspected and recently a large number of studies have been published in the dental literature regarding this possible role. Much of the literature has also indicated that smokers affected with periodontitis respond less favorably to periodontal treatment be it non-surgical, surgical and regenerative. This paper will review the current literature regarding the effects of smoking on various aspects of the periodontal disease process and present an explanation for the possible association between smoking and the progression of periodontitis.

Matched MeSH terms: Periodontal Diseases

Periodontal status of 16-year-old west Malaysian urban students

Abdul-Kadir R

Community Dent Oral Epidemiol, 1990 Dec;18(6):324.

PMID: 2090388

Matched MeSH terms: Periodontal Diseases/epidemiology*

The rate of loss of maxillary anterior alveolar bone height in patients with leprosy

Subramaniam K, Marks SC, Seang Hoo Nah

Lepr Rev, 1983 Jun;54(2):119-27.

PMID: 6888141

Matched MeSH terms: Periodontal Diseases/etiology

A periodontal programme for a developing country (Western Samoa)

Camrass R

Dent J Malaysia Singapore, 1973 May;13(1):45-50.

PMID: 4149372

Matched MeSH terms: Periodontal Diseases/epidemiology

Fulltext Association between Perceived Oral Symptoms and Presence of Clinically Diagnosed Oral Diseases in a Sample of Pregnant Women in Malaysia

Yunita Sari E, Saddki N, Yusoff A

Int J Environ Res Public Health, 2020 10 08;17(19).

PMID: 33049972 DOI: 10.3390/ijerph17197337

The integration of oral health into primary health care denotes the important role of medical counterparts as the front liners in antenatal care to help screen mothers for oral symptoms and refer them to dentists accordingly. However, the validity of self-perceived oral health status is inconclusive. This study determined the association between self-perceived oral symptoms and the presence of clinically diagnosed oral diseases in a sample of pregnant women. A total of 192 pregnant women participated in this cross-sectional study. Clinical oral examinations were performed to record dental caries experience, gingival health and periodontal health. The women were also asked about their oral symptoms. Most women had at least one oral symptom (84.9%): cavitated tooth (62.0%), bad breath (38.5%), bleeding gums (28.6%), and toothache (22.9%). About half of the women had untreated dental caries (58.9%), and the odds were significantly higher in women who complained of having cavitated tooth. About half of the women had moderate to severe gingivitis (53.7%), and the odds were significantly higher in women who complained of bleeding gums. About half had periodontal pockets (46.3%), and the odds were higher in women who complained of bleeding gums and bad breath although lower in women who complained of swollen gums. In conclusion, the prevalence of dental caries and periodontal disease among pregnant women in this study were relatively high. The presence of untreated dental caries, moderate and severe gingivitis, and periodontal pockets were significantly associated with their corresponding oral symptoms.

Matched MeSH terms: Periodontal Diseases*

Relationship of periodontal disease and domains of oral health-related quality of life

Masood M, Younis LT, Masood Y, Bakri NN, Christian B

J Clin Periodontol, 2019 02;46(2):170-180.

PMID: 30657192 DOI: 10.1111/jcpe.13072

OBJECTIVES: The aim of this study was to investigate the impact of periodontal disease on the domains of oral health-related quality of life (OHRQoL) of United Kingdom adults.

METHODS: National representative data from the 2009 Adult Dental Health Survey, United Kingdom, were used in this study. Periodontal disease severity was measured using periodontal pocket depth and categorized into three groups: pocket depth up to 3.5, 3.5-5.5 and more than 5.5 mm. OHRQoL was measured using the Oral Health Impact Profile-14 (OHIP-14) scores. Bivariate and multivariable Zero-inflated Poisson regression analysis was used.

RESULTS: A total of 6378 participants was analysed in this study. Periodontal pocketing was significantly associated with higher OHIP-14 scores. Participants with periodontal pocket depths >3.5 mm had a significantly higher prevalence for functional limitation, physical pain and social disability than participants with pocket depths of less than 3.5 mm. Participants with periodontal pocket depth(s) >5.5 mm had significantly higher OFOVO prevalence in all the domains of OHIP-14 except handicap domain than participants with pocket depth(s) <3.5 mm.

PARTICIPANTS:

CONCLUSION: This study showed that for a nationally representative sample of the United Kingdom population, periodontal disease was significantly associated with the domains of OHRQoL.

Matched MeSH terms: Periodontal Diseases*

Bactericidal Efficacy of Photodynamic Therapy Against Periodontal Pathogens in Periodontal Disease: A Systematic Review

Akram Z, Al-Shareef SA, Daood U, Asiri FY, Shah AH, AlQahtani MA, et al.

Photomed Laser Surg, 2016 Apr;34(4):137-49.

PMID: 26982216 DOI: 10.1089/pho.2015.4076

The aim of this study was to assess the bactericidal efficacy of antimicrobial photodynamic dynamic therapy (aPDT) as an adjunct to scaling and root planing (SRP) against periodontal pathogens.

Matched MeSH terms: Periodontal Diseases/drug therapy; Periodontal Diseases/microbiology*; Periodontal Diseases/therapy*

Fulltext Periodontal disease as the initial oral manifestation of langerhans cell histiocytosis - a case report

Ahmad AR, Ismail SM, Zain RB, Mohamad Zaini Z

Ann Dent, 2009;16(1):31-36.

MyJurnal

Langerhans Cell Histiocytosis (LCH) refers to a group of lesions presenting with a spectrum of clinical. features but sharing similar histology. These lesions are rare and treatment has been quite variable with current treatment protocol recommended being dependent on whether it is a unifocal or multi focal bone disease or a multi focal multisystem disease. However, the clinical presentations of LCH are variable and the decision to place into the appropriate clinical types may sometimes be masked by the non-discovery of all the lesions. In the oral maxillofacial area, the clinical features of these lesions may further pose a problem by nondescript manifestations as dental/periodontal/oral mucosal disorders. These oral findings may sometimes lead to inappropriate choice of treatment and delay in the diagnosis of all the lesions involved. This paper describes one such case where LCH manifest itself as a periodontal disease thus leading to delay in identifying all the sites involved and consequently a delay in id~ntifying the appropriate clinical type.

Matched MeSH terms: Periodontal Diseases

Fulltext The prevalence of Actinobacillus actinomycetemcomitans in a healthy Malay population in Malaysia

Zahari, N.M., Ismail, R., Bunyarit, S.S., Shafiei, Z., Al Rawenduzy, K.C.M.A.

Malaysian Dental Journal, 2007;28(1):45-50.

MyJurnal

Actinobacillus actinomycetemcomitans is considered a major pathogen in periodontal disease. The aim of this study was to determine the prevalence of A. actinomycetemcomitans from 46 subjects aged 20-24 years old of who were all periodontally healthy Malays.

Matched MeSH terms: Periodontal Diseases

Lactate dehydrogenase activity during tooth movement under 1.0 N and 1.5 N continuous force applications

Shahrul Hisham Zainal Ariffin, Nurfathiha Abu Kasim, Rohaya Megat Abdul Wahab, Abdul Aziz Jemain

Sains Malaysiana, 2013;42:99-105.

The aim of this study was to observe the pattern of lactate dehydrogenase (LDH) activity in GCF and the rate of tooth movement at two different orthodontic forces (1.0 N and 1.5 N). Twelve subjects participated in this study and was chosen based on the inclusion criteria. Each subject received forces of 1.0 N and 1.5 N for tooth movement either on the left or right side of the maxillary canine. GCF sample was collected at mesial and distal sites of the canines before applying the appliance (week 0) and every week for 5 weeks after tooth movement (week 1 to week 5) where baseline activity served as control. LDH activity was assayed spectrophotometically at 340 nm. The tooth movements were measured from casted study models. LDH specific activity at mesial sites in 1.0 N and 1.5 N force groups, respectively increased significantly (p<0.05) only on week four and throughout the treatment when compared with baseline. At distal sites, LDH specific activity with 1.5 N was higher than 1.0 N throughout the five weeks of tooth movement. LDH specific activity with 1.5 N force increased at both mesial (week 2) and distal sites (week 3) with significant different (p<0.05) when compared with 1.0 N force. Tooth movement with 1.5 N showed significantly faster (p<0.05) at the end of week 5 when compared with 1.0 N. LDH has the potential as a biological marker of inflammation during tooth movement.A force of 1 N was more suitable to be used although less tooth movement was produced because less inflammation caused by the force can be useful in orthodontic treatment for patients with stabilised periodontal diseases compared with 1.5 N force.

Matched MeSH terms: Periodontal Diseases

Periodontal treatment needs and workforce requirements: comparisons between the normative and sociodental approaches using different skill mix models

Ab-Murat N, Sheiham A, Tsakos G, Watt R

Community Dent Oral Epidemiol, 2015 Apr;43(2):106-15.

PMID: 25178437 DOI: 10.1111/cdoe.12125

Assessment of dental treatment needs has predominantly been based on the normative approach, despite its numerous limitations. The sociodental approach is a more rational method of needs assessment as it incorporates broader concepts of health and needs and behavioural propensity. This study compares estimates of periodontal dental treatment needs and workforce requirements for different skill mixes using normative and sociodental approaches among a sample of adults in Malaysia.

Matched MeSH terms: Periodontal Diseases/epidemiology*; Periodontal Diseases/therapy

A retrospective study of periodontal disease severity in smokers and non-smokers

Razali M, Palmer RM, Coward P, Wilson RF

Br Dent J, 2005 Apr 23;198(8):495-8; discussion 485.

PMID: 15849588

Smoking has been associated with increased risk of periodontitis. The aim of the present study was to compare the periodontal disease severity of adult heavy smokers and never-smokers referred for assessment and treatment of chronic periodontitis.

Matched MeSH terms: Periodontal Diseases/complications*; Periodontal Diseases/radiography

Periodontal profile of 15- to 19-year-old West Malaysian secondary school students

Abdul-Kadir R

J Nihon Univ Sch Dent, 1994 Mar;36(1):34-9.

PMID: 8207502

A cross-sectional exploratory survey was conducted in six West Malaysian schools involving 762 fifteen- to eighteen-year-old secondary school students. Periodontal health status was assessed using the Community Periodontal Index of Treatment Needs (CPITN), utilizing six index teeth to represent the six sextants of the mouth. The results indicated that 66.8% of the students examined had healthy gingiva (Score 0), 2.6% had bleeding of the gingiva on gentle probing, while 30.6% had calculus on their teeth. In terms of treatment needs, 35.0% of those examined needed oral hygiene education, 34.4%, on the other hand, required scaling. No student was found to require complex treatment. Sex-specific comparison revealed a slightly higher prevalence of calculus formation in male students. In terms of race, the Malays had a higher prevalence of calculus formation than either Chinese or Indians.

Matched MeSH terms: Periodontal Diseases/ethnology; Periodontal Diseases/epidemiology*

Periodontal status (CPITN) of six-to fifteen-year-old west Malaysian aborigines (Proto-Malays)

Abdul-Kadir R, Yassin AT

J Nihon Univ Sch Dent, 1989 Dec;31(4):612-8.

PMID: 2621482

A survey of 303 six- to fifteen-year-old Proto-Malay children was carried out in Selangor, West Malaysia. The examinations were carried out using a chair-table and natural daylight. Periodontal status was assessed using the Community Periodontal Index of Treatment Needs (CPITN). The findings revealed a generally low prevalence of periodontal disease affecting only 25.08% of the sample examined. Of these, 15.72% were found to have a score of 1 (bleeding of the gingiva), while 9.36% had calculus on the tooth surface. In terms of treatment needs, 24.75% required dental health education. The relationship between these findings and the possible causes are discussed.

Matched MeSH terms: Periodontal Diseases/epidemiology*; Periodontal Diseases/therapy

Trends in tooth loss due to caries and periodontal disease by tooth type

Jaafar N, Razak IA, Nor GM

Singapore Dent J, 1989 Dec;14(1):39-41.

PMID: 2487474

Although the patterns of dental disease is gradually changing, caries and periodontal disease still account for the most important reason for extractions in most countries. However their relative contributions towards overall tooth mortality figures varies. The aim of this study is to investigate the types of teeth usually associated with extractions due to caries or periodontal disease and its relation to the age at which the tooth was lost. The highest proportion of extractions due to caries occurred between 21 to 30 years of age while that for periodontal disease occurred between 41 to 50 years. For caries, the greatest proportion of extractions involved the posterior teeth. The most frequently extracted teeth due to caries are the molars, in particular the first permanent molar. However, for periodontal disease a slightly greater proportion of anterior teeth were lost than the posteriors. This trend is more marked in the lower jaw than the upper. Overall, extractions related to caries tend to increase posteriorly, while that for periodontal disease tend to increase anteriorly.

Matched MeSH terms: Periodontal Diseases/complications*; Periodontal Diseases/epidemiology

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