MyMedR

INTRODUCTION: Drug-resistant fungal infections in chronic wounds represent a major clinical challenge to clinicians. Fungal infections delay wound healing by prolonging inflammation and encouraging biofilm formation, which protects microbes against host defenses and anti-infective medications. As such, interventions that prevent and control nosocomial fungal infections without interfering with the wound healing process are increasingly required. Although conventional antiseptics can effectively exert fungicidal effects, they also have adverse effects on human cells. SOS is a well-known bactericidal agent that enhances the wound healing process, especially for chronic wounds. However, few studies have evaluated the antimicrobial activity of SOS on fungi.

OBJECTIVE: The objective of this study was to evaluate whether SOS exerts fungicidal activities against common fungal species.

MATERIALS AND METHODS: The efficacy of SOS was tested against 6 fungal species (Candida albicans, Candida auris, Candida tropicalis, Candida parapsilosis, Sporothrix schenckii, Trichophyton mentagrophytes) using an in vitro time-kill assay.

RESULTS: SOS achieved 99.9999% reduction of all tested fungi within 1 minute of exposure.

CONCLUSIONS: This study shows that SOS may be an effective tool for the prevention and control of fungal infections.

Matched MeSH terms: Cross Infection*

Hospital infection control in Malaysia

Lim VK

J Hosp Infect, 2001 Jul;48(3):177-9.

PMID: 11439003

Matched MeSH terms: Cross Infection/epidemiology; Cross Infection/prevention & control*; Infection Control*

Fulltext Emerging and re-emerging infections

Lim VK

Med J Malaysia, 1999 Jun;54(2):287-91; quiz 292.

PMID: 10972048 MyJurnal

An emerging infection is defined as an infection which has newly appeared in a population while a re-emerging infection is one which has existed in the past but its incidence is rapidly increasing. The reasons for the emergence and re-emergence of infections are not well understood but appear to be associated with factors that involve the pathogen, the host and the environment. These factors are often inter-related and act together in a complex manner to bring about changes in patterns of infection. Pathogens are extremely resourceful and possess mechanisms to adapt to new hosts and environments as well as to acquire new virulence traits. Host factors include herd immunity, social behaviour and demographics. Environmental factors like the climate, deforestation and new technologies have an impact on the emergence of infections. The challenge is to contain an infection when it emerges but more importantly to prevent its emergence in the first place. As the emergence of an infection is complex and multifactorial, a multidisciplinary approach is required. Health based strategies alone are insufficient. Social, economic and environmental measures and the political will to implement appropriate policies are equally important.

Matched MeSH terms: Infection/etiology*; Infection/epidemiology

Definition, diagnosis and classification of infection-related movement disorders: Consensus proposal

Desai S, Ibrahim NM, Garg D, Yadav R, Iacono D, Ugawa Y, et al.

Parkinsonism Relat Disord, 2024 Jul;124:106988.

PMID: 38705765 DOI: 10.1016/j.parkreldis.2024.106988

BACKGROUND: Infection-related movement disorders (IRMD) present a complex diagnostic challenge due to the broad phenotypic spectrum, the variety of possible infectious aetiologies, and the complicated underlying mechanisms. Yet, a comprehensive framework for classifying IRMD is lacking.

METHODS: An international consensus panel under the directives of the Movement Disorders Society Infection-Related Movement Disorders Study Group developed a comprehensive definition and a consensus classification system. Case scenarios were used for validation.

RESULTS: A definition for IRMD and a two-axis-based classification system consisting of six descriptors are proposed, intended as tools for researchers and clinicians. Collected information on clinical characteristics, investigational findings, the infectious organism and presumed pathogenesis facilitate the evaluation of diagnostic certainty.

CONCLUSION: The proposed framework will serve for optimised diagnostic algorithms, systematic aggregation of informative datasets across studies, and ultimately improved care and outcome of patients with IRMDs.

Matched MeSH terms: Infection/complications; Infection/diagnosis

Honey use in burn management: potentials and limitations

Boukraâ L, Sulaiman SA

Forsch Komplementmed, 2010 Apr;17(2):74-80.

PMID: 20484914 DOI: 10.1159/000297213

Management of the burn wound still remains a matter of debate, and an ideal dressing for burn wounds has not yet been discovered. Naturally occurring substances such as honey have been found to be useful as a wound cover for burns. Unlike most conventional local chemotherapeutics, honey does not lead to the development of antibiotic-resistant bacteria, and it may be used continuously. Among the challenging problems of using honey for medical purposes are dosage, safety, and formulation. Many approaches have been suggested to overcome such problems. With the increased availability of licensed medical products containing honey, clinical use is expected to increase and further evidence will become available. Honey seems to have the potential to clear infection as well as to be an effective prophylactic agent that may contribute to reducing the risks of cross-infection. A better understanding of the therapeutic and chemical properties of honey is needed to optimise the use of this product in the clinical management of burns. Its use in professional care centres should be limited to those with certified healing activities. The potentials and limitations of using honey as burn dressing are discussed in this review.

Matched MeSH terms: Cross Infection/therapy; Wound Infection/therapy*

Urinary tract infection in childhood

Jai Mohan A

Family Practitioner, 1983;6:19-22.

Matched MeSH terms: Infection; Urinary Tract Infections

Displaying publications 1 - 20 of 605 in total