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Fascioliasis in cattle near Kuala Lumpur

Griffiths RB, Nagendram C

Med J Malaya, 1965 Sep;20(1):60.
PMID: 4221422
Matched MeSH terms: Fascioliasis*
Fasciolosis (liver fluke) of the breast in a male patient: a case report

Naresh G, Gomez PA, Salmah B, Suryati MY

Breast, 2006 Feb;15(1):103-5.
PMID: 16024249

Fasciolosis is an uncommon disease in this region, as are parasitic infections of the breast. This report describes a 56-year-old man with a previous history of liver abscess presenting with a painful breast mass. He underwent a mastectomy and is well. The pathological findings revealed chronic granulomatous mastitis with Fasciola spp. ova. The literature on this very rare condition is reviewed.

Matched MeSH terms: Fascioliasis/pathology; Fascioliasis/surgery*
Fulltext Lack of efficacy of triclabendazole against Fasciola hepatica is present on sheep farms in three regions of England, and Wales

Kamaludeen J, Graham-Brown J, Stephens N, Miller J, Howell A, Beesley NJ, et al.

Vet Rec, 2019 04 20;184(16):502.
PMID: 30824600 DOI: 10.1136/vr.105209

The liver fluke Fasciola hepatica is a parasitic trematode that has a major impact on livestock production and human health. Control of F hepatica is difficult and relies on anthelmintics, particularly triclabendazole, due to its efficacy against both adult and juvenile stages of the parasite. Emergence of triclabendazole-resistant F hepatica populations has been reported in a number of countries, including the UK, but the overall prevalence and distribution of triclabendazole resistance is unknown. In this study, the authors established the presence of reduced efficacy of triclabendazole in sheep flocks in England and Wales, using a validated composite faecal egg count reduction test. Seventy-four sheep farms were sampled from Wales, southwest, northwest and northeast England between Autumn 2013 and Spring 2015. F hepatica eggs were detected in samples from 42/74 farms. Evidence of a lack of efficacy of triclabendazole was detected on 21/26 farms on which the faecal egg count reduction test was completed, with faecal egg count reductions ranging from 89 per cent to 0per cent. Regression analysis suggested that both prevalence of F hepatica and lack of efficacy of triclabendazole were spatially correlated, with higher faecal egg counts and lower percentage reductions on farms located in the northwest of England, and Wales. Overall, the results show that reduced efficacy of triclabendazole is present across England and Wales, with a complete lack of therapeutic efficacy observed on 9/26 farms.

Matched MeSH terms: Fascioliasis/drug therapy; Fascioliasis/veterinary*
Liver fluke disease (fascioliasis): epidemiology, economic impact and public health significance

Saleha AA

Southeast Asian J Trop Med Public Health, 1991 Dec;22 Suppl:361-4.
PMID: 1822928

Liver fluke disease (fascioliasis) is an important parasitic disease found worldwide affecting sheep, goats, cattle and buffalo, as well as other domestic ruminants. The common causative agents are Fasciola hepatica and F. gigantica which require various species of Lymnaea, fresh water snails, as their intermediate hosts. The epidemiology of the disease and its prevalence in Malaysia is mentioned briefly. The disease causes considerable impact on the economy of the livestock industry. The economic losses consist of costs of anthelmintics, drenches, labor, liver condemnation at meat inspection; and losses in production due to mortality, reduction in meat, milk and wool production; and reduction in growth rate, fertility and draught power. The disease also has public health significance, causing human fascioliasis and "halzoun".

Matched MeSH terms: Fascioliasis/economics; Fascioliasis/epidemiology*
High seroprevalence of anti-Fasciola antibody among cattle farm workers and dwellers in Kelantan

Najib MA, Noor-Izani NJ, Wan-Nor-Amilah WAW, Wong WK, Faez AM

Trop Biomed, 2020 Jun 01;37(2):389-396.
PMID: 33612808

Human fascioliasis is a public health problem particularly in areas where ruminants are raised. The aims of this study were to determine the seroprevalence of anti-Fasciola antibody and the associated risk factors among cattle farm workers and dwellers in Kelantan. A total of 90 blood samples were collected in this cross-sectional study. A set of validated questionnaire was used to obtain information on socio-demographic profiles and dietary habits of participants. The sera were subjected to enzyme linked immunosorbent assay (ELISA) for the detection of anti-Fasciola IgG antibody. The association between seropositivity and the significant risk factors were determined via logistic regression. From the result, serological screening revealed 60 (67%) participants positive for anti-Fasciola IgG antibody. The factors found to be significantly associated with seropositivity against anti-Fasciola IgG antibody were the age group of 18 years old and above with calculated odds ratio of 3.2 times (p=0.032) and the duration of farming activities of more than 5 years with calculated odds ratio of 2.6 times (p=0.036). In conclusion, Fasciola infection is prevalent among cattle farm workers and dwellers in Kelantan.

Matched MeSH terms: Fascioliasis/diagnosis*; Fascioliasis/epidemiology
Fulltext Fasciolasis in Tuaran, Sabah: A Case Report

Bizini, Fionna Vincent

Borneo Journal of Medical Sciences, 2018;12(101):35-36.
MyJurnal

Fascioliasis is a major parasitic disease caused by the liver flukes, Fasciola hepatica and Fasciola gigantica in Malaysia. On 31st May 2016, three cases of fasciolasis among humans were notified in Tuaran involving two localities.

Matched MeSH terms: Fascioliasis
Fulltext A Retrospective Study on Bovine Fascioliasis in Veterinary Regional Laboratories in Peninsular Malaysia

Diyana JNA, Lokman IH, Fazila SHN, Latiffah H, Ibitoye EB, Hazfalinda HN, et al.

J Parasitol Res, 2019;2019:7903682.
PMID: 31354983 DOI: 10.1155/2019/7903682

This is a retrospective study on bovine fascioliasis infection on cattle in Peninsular Malaysia, spanning from January 2007 to December 2017. Cattle were diagnosed with Fasciola based on the fecal examination and the results were reported to the Veterinary Regional Laboratories in Peninsular Malaysia. These records were analysed for the occurrence of bovine fascioliasis within that 11-year period. Records of annual diagnostic cases from five major Veterinary Regional Laboratories were examined: Bukit Tengah, Pulau Pinang (north); Kuantan, Pahang (east); Johor Bahru, Johor (south); Sepang, Selangor (west); and Kota Bharu, Kelantan (east). A positive fascioliasis infestation was calculated based on a number of positively infected cattle with Fasciola from a number of cattle examined. A total of 1988 cattle were examined during this period and 35 (1.76%) cattle were reported to be positive for bovine fascioliasis. Parasite infection was the highest at Bukit Tengah region (5.55%) where 19 cases were positive from 342 reported cases while, at Kuantan (4.96%), 15 positive cases were reported, unlike Johor Bahru (0.09%), with only 1 positive case from 1136 cattle examined. Sepang and Kelantan had no positive cases. These results showed that bovine fascioliasis was generally prevalent in the northern and southeast parts of the Peninsular Malaysia; however, there was no significant relationship between the region and the occurrence of fascioliasis.

Matched MeSH terms: Fascioliasis
Parasitological and molecular detection of human fascioliasis in a young man from Guizhou, China

Chen MX, Zhang RL, Xu XN, Yu Q, Huang DN, Liu W, et al.

Trop Biomed, 2020 Mar 01;37(1):50-57.
PMID: 33612717

A 24-year-old man born in Guizhou province was diagnosed with obstructive jaundice and bile duct stones in 2013. Four living trematodes were found during laparotomy and cholecystectomy. Based on the morphology and molecular genetics analysis of internal transcribed spacer and pcox1 genes of the flatworm specimens, the trematodes from the patient were confirmed to be Fasciola hepatica. This report provided the clinical and molecular diagnosis information on human fascioliasis, which is an emerging sanitary problem still ignored in China. Human fascioliasis constantly occurs due to climatic changes and frequency of human travel. Therefore, it deserves more attention from physicians working in both developing and developed countries.

Matched MeSH terms: Fascioliasis/diagnosis*
Fulltext Evaluation of the Diagnostic Performance of Recombinant Antigen B1 for Detection of Cystic Echinococcosis Using Lateral Flow Dipstick Test

Noordin R, Khanbabaie S, Hafiznur Yunus M, Marti H, Nickel B, Fasihi Harandi M, et al.

Iran J Parasitol, 2020 10 22;15(3):290-298.
PMID: 33082792 DOI: 10.18502/ijpa.v15i3.4191

Background: Human echinococcosis is a neglected zoonotic disease distributed worldwide. It comprises cystic and alveolar forms, the former being the more prevalent disease. Imaging techniques are the first choice for diagnosis of cystic echinococcosis and serology is used as an additional diagnostic technique in doubtful cases or as the sole test in low-resource settings. Rapid diagnostic tests are useful and convenient for immunodiagnosis of cystic echinococcosis in endemic areas, where medical facilities often struggle with limited resources.
Methods: Recently, we have developed Hyd Rapid™, an IgG4 lateral flow dipstick test using recombinant antigen B1 for detection of cystic echinococcosis. This study was performed between 2016 until 2018 at the Institute for Research in Molecular Medicine, Universiti Sains Malaysia. The diagnostic performance of Hyd Rapid™ was tested in-house and at two international laboratories in Switzerland and Iran.
Results: The overall diagnostic sensitivity for detection of cystic and alveolar echinococcosis was 95% (56/59). Meanwhile, the diagnostic specificity, with and without exclusion of cysticercosis and fascioliasis, was 100% (n=48) and 88% (63/72), respectively.
Conclusion: Hyd Rapid™ detected cystic echinococcosis as well as probable cases of alveolar echinococcosis. Therefore, Hyd Rapid™ showed good potential as a serological tool for echinococcosis, and merits further evaluation.

Matched MeSH terms: Fascioliasis
Fulltext Screening for Zoonotic Fascioliasis in Slaughtered Large Ruminants in Abattoirs in Perak, Malaysia

Zainalabidin FA, Azmi MS, Bakri WN, Sathaya G, Ismail MI

Trop Life Sci Res, 2015 Dec;26(2):121-4.
PMID: 26868715 MyJurnal

Fascioliasis, or trematode infestation, is an important disease caused by Fasciola hepatica and Fasciola gigantica. Both species are hepatic parasites that affect humans. We have examined the zoonotic aspects of fascioliasis. A total of 80 fresh liver samples were collected from 67 Kedah-Kelantan crossbred cattle and 13 Murrah buffalo at 4 local abattoirs in Perak, Malaysia. The samples were examined macroscopically to detect the presence of Fasciola spp. The results show 7.50% (6 of 80) of the animals were diagnosed with fascioliasis. Overall, 7.46% (5 of 67) and 7.69% (1 of 13) of cattle and buffalo samples were positive, respectively. There were only F. gigantica species identified in the samples. Our findings suggest that precautions should be taken because the disease has a zoonotic impact on public health.

Matched MeSH terms: Fascioliasis
Fulltext Toxicity of Chlorophyllin against Lymnaea acuminata at Different Wavelengths of Visible Light

Chaturvedi D, Singh VK

Trop Life Sci Res, 2016 Aug;27(2):25-36.
PMID: 27688849 DOI: 10.21315/tlsr2016.27.2.3

Fasciolosis is a water and food-borne disease caused by the liver fluke Fasciola hepatica and Fasciola gigantica. This disease is widespread in different parts of the world. Lymnaeidae and Planorbidae snails are the intermediate hosts of these flukes. Snail population management is a good tool to control fasciolosis because gastropods represent the weakest link in the life-cycle of trematodes. Chlorophyll can be extracted from any green plant. Chlorophyllin was prepared from spinach in 100% ethanol by using different types of chemicals. The chlorophyll obtained from spinach was transformed into water-soluble chlorophyllin. In the present paper, toxicity of chlorophyllin against the snail Lymnaea acuminata was time and concentration dependent. The toxicity of extracted and pure chlorophyllin at continuous 4 h exposure of sunlight was highest with lethal concentration (LC50) of 331.01 mg/L and 2.60 mg/L, respectively, than discontinuous exposure of sunlight up to 8 h with LC50 of 357.04 mg/L and 4.94 mg/L, respectively. Toxicity of extracted chlorophyllin was noted in the presence of different monochromatic visible lights. The highest toxicity was noted in yellow light (96 h, LC50 392.77 mg/L) and the lowest in green light (96 h, LC50 833.02 mg/L). Chlorophyllin in combination with solar radiation or different wavelength of monochromatic visible lights may become a latent remedy against the snail L. acuminata. It was demonstrated that chlorophyllin was more toxic in sunlight. Chlorophyllin is ecologically safe and more economical than synthetic molluscicides which have the potential to control the incidence of fasciolosis in developing countries.

Matched MeSH terms: Fascioliasis
Fulltext Seroprevalence of fascioliasis, toxocariasis, strongyloidiasis and cysticercosis in blood samples diagnosed in Medic Medical Center Laboratory, Ho Chi Minh City, Vietnam in 2012

Nguyen T, Cheong FW, Liew JW, Lau YL

Parasit Vectors, 2016 09 05;9(1):486.
PMID: 27595647 DOI: 10.1186/s13071-016-1780-2

BACKGROUND: Despite the global effort against neglected tropical diseases (NTDs), developing countries with middle to low income are still burdened by them. Vietnam has been undergoing substantial economic growth and urbanization, but underprivileged people living in rural and suburban areas are still having little access to public health infrastructure and proper sanitation. Hitherto, limited information is available for seroprevalence and risk factors of several parasitic diseases in Vietnam.
METHODS: A retrospective study was performed on diagnostic results of Fasciola spp., Toxocara spp., Strongyloides stercoralis and Taenia solium IgG ELISA tests from Medic Medical Center Laboratory, Ho Chi Minh City in 2012. The data were first stratified before statistical analyses were performed. Seroprevalence of fascioliasis, toxocariasis, strongyloidiasis and cysticercosis was determined and the age and gender risk factors were evaluated.
RESULTS: Seroprevalence of fascioliasis, toxocariasis, strongyloidiasis and cysticercosis was 5.9 % (590/10,084; 95 % CI: 5.44-6.36), 45.2 % (34,995/77,356; 95 % CI: 44.85-45.55), 7.4 % (3,174/42,920; 95 % CI: 7.15-7.65) and 4.9 % (713/14,601; 95 % CI: 4.55-5.25), respectively. Co-exposure to multiple parasites was detected in 890 males (45.7 %; 95 % CI: 43.49-47.91) and 1,059 females (54.3 %; 95 % CI: 52.09-56.51). Social structure and differences in behavioural factors caused the gender factor to have a significant effect on the prevalence of all the diseases, while the seropositivity for fascioliasis and strongyloidiasis were age group-related.
CONCLUSIONS: The seroprevalence of fascioliasis, toxocariasis, strongyloidiasis and cysticercosis in the blood samples diagnosed in Medic Medical Center Laboratory, Ho Chi Minh City, in year 2012 were comparatively high. The Vietnamese customs and cultures, dietary habits and agricultural practices exposed them to high risk of contracting NTDs. Despite the possibility of false positive results due to antigenic cross-reactions, detection of IgG antibodies remains as a reliable method in sero-epidemiological study as it is non-invasive and demonstrates previous exposure of individuals to the parasites. Besides the implementation of strategies to control these diseases, epidemiological analysis and surveillance of diseases should also be continually strengthened to monitor the effectiveness of regimens and interventions.

Matched MeSH terms: Fascioliasis/diagnosis; Fascioliasis/immunology; Fascioliasis/epidemiology*