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  1. Wan Ngah WS, Hanafiah MA, Yong SS
    Colloids Surf B Biointerfaces, 2008 Aug 1;65(1):18-24.
    PMID: 18359205 DOI: 10.1016/j.colsurfb.2008.02.007
    The adsorption of humic acid on crosslinked chitosan-epichlorohydrin (chitosan-ECH) beads was investigated. Chitosan-ECH beads were characterized by Fourier transform infrared spectroscopy (FTIR), surface area and pore size analyses, and scanning electron microscopy (SEM). Batch adsorption experiments were carried out and optimum humic acid adsorption on chitosan-ECH beads occurred at pH 6.0, agitation rate of 300 rpm and contact time of 50 min. Adsorption equilibrium isotherms were analyzed by Langmuir and Freundlich models. Freundlich model was found to show the best fit for experimental data while the maximum adsorption capacity determined from Langmuir model was 44.84 mg g(-1). The adsorption of humic acid on chitosan-ECH beads was best described with pseudo-first-order kinetic model. For desorption study, more than 60% of humic acid could be desorbed from the adsorbent using 1.0M HCl for 180 min.
    Matched MeSH terms: Epichlorohydrin/chemistry*
  2. Nurul Najwa Abd Malek, Ali H. Jawad, Emad Yousif
    Science Letters, 2020;14(1):83-95.
    MyJurnal
    Cross-linked chitosan-epichlorohydrin was prepared for the adsorption of Reactive Red 4 (RR4).
    Response surface methodology (RSM) with 3–level Box-Behnken design (BBD) was employed to
    optimize the RR4 dye removal efficiency from aqueous solution. The adsorption key parameters that were selected such as adsorbent dose (A: 0.5 – 1.5 g), pH (B: 4 – 10) and time (30 – 80 min). The F-value of BBD model for RR4 removal efficiency was 185.36 (corresponding p-value < 0.0001). The results illustrated that the highest RR4 removal efficiency (70.53%) was obtained at the following conditions: adsorbent dose (1.0 g), pH 4 and time of 80 min.
    Matched MeSH terms: Epichlorohydrin
  3. Shamsudin MS, Taib MHA, Azha SF, Bonilla-Petriciolet A, Ismail S
    Environ Sci Pollut Res Int, 2023 Dec;30(60):124596-124609.
    PMID: 35608765 DOI: 10.1007/s11356-022-20815-9
    This study reports the analysis of diclofenac removal from aqueous solution using a novel adsorbent coating with amphoteric surface. This adsorbent coating was improved using a new amphoteric ratio to increase its performance for the removal of pharmaceuticals such as diclofenac. The adsorbent coating was formulated using acrylic polymer emulsion, smectite-based clay powder and epichlorohydrin-dimethylamine to obtain a layer form via the implementation of a facile synthesis method. In a previous study, this adsorbent coating was successful to remove cationic and anionic dyes. Therefore, this research aimed to further investigate and test its application in the removal of other emerging water pollutants like pharmaceuticals. SEM, EDX, and FTIR analyses were carried out for the characterization of this novel adsorbent. The effects of adsorbent composition, diclofenac concentration, temperature, and solution pH were studied and modeled. The best conditions to improve the diclofenac adsorption was 303 K and pH 3 where the adsorption capacity was 25.59 mg/g. Adsorption isotherms and kinetics were quantified and modeled, and the corresponding adsorption mechanism was also analyzed. Diclofenac adsorption with this novel material was exothermic and spontaneous. This alternative adsorbent is promising for diclofenac removal from industrial wastewater systems.
    Matched MeSH terms: Epichlorohydrin
  4. Jawad AH, Abdulhameed AS, Malek NNA, ALOthman ZA
    Int J Biol Macromol, 2020 Dec 01;164:4218-4230.
    PMID: 32861784 DOI: 10.1016/j.ijbiomac.2020.08.201
    In current research work, chitosan (Chi) was subjected to subsequent physical and chemical modifications by incorporating kaolin clay (KA) into its polymeric structure, and crosslinking process with a covalent cross-linker namely epichlorohydrin (ECH) respectively. The final product of crosslinked chitosan-epichlorohydrin/kaolin (Chi-ECH/KA) composite was successfully applied for color removal and chemical oxygen demand (COD) reduction of textile dye namely reactive blue 19 dye (RB19) from aqueous environment. The influence of pertinent parameters, i.e. A: Chi-ECH/KA dose (0.02-0.1 g), B: pH (4-10), and C: time (5-30 min) on the RB19 color removal and COD reduction were statistically optimized by using response surface methodology with Box-Behnken design (RSM-BBD). The experimental data of the adsorption kinetic and the adsorption isotherm demonstrated a better fitness to pseudo-second order model and Langmuir isotherm model respectively. Excellent absorption ability of 560.9 mg/g was recorded for Chi-ECH/KA composite. The calculated thermodynamic functions clarified that the RB19 adsorption process was endothermic and spontaneous in nature. The mechanism of RB19 adsorption onto the Chi-ECH/KA may include electrostatic interactions, hydrogen bonding, Yoshida H-bonding, and n-π interactions. This study introduces Chi-ECH/KA composite as an eco-friendly, potential and multi-function composite bio adsorbent for removal of textile dye and COD reduction from aqueous environment.
    Matched MeSH terms: Epichlorohydrin/chemistry*
  5. Ibrahim Awad Mohammed, Abdallah Reghioua, Emad Yousif, Ali H. Jawad, Nurul Najwa Abd Malek
    Science Letters, 2020;14(1):96-108.
    MyJurnal
    Chitosan-epichlorohydrin/TiO2 composite was synthesized to be employed as an adsorbent for the
    removal of reactive red 4 (RR4) dye from aqueous solution. Response surface methodology (RSM) with 3-level Box-Behnken design (BBD) was utilized for the optimization of the removal of RR4. The process key variables which include adsorbent dose (A: 0.5 – 1.5 g), pH (B: 4 – 10) and time (30 – 80 min) were selected for the optimization process. The experimental data for RR4 removal were statistically analysed using analysis of variance (ANOVA). The significant interaction between key parameters on RR4 removal efficiency was observed by interaction between AB and AC. The highest RR4 removal (95.08%) was obtained under the following conditions; adsorbent dose (1.0 g), pH 4 and time of 80 min.
    Matched MeSH terms: Epichlorohydrin
  6. Jawad AH, Nawi MA
    Carbohydr Polym, 2012 Sep 1;90(1):87-94.
    PMID: 24751014 DOI: 10.1016/j.carbpol.2012.04.066
    Photocatalytic oxidation of crosslinked chitosan-epichlorohydrin (CS-ECH) film was successfully achieved via an immobilized TiO2/CS-ECH photocatalyst system on a glass plate. Oxidation process of CS-ECH film was carried out by irradiating the system with a 45-W fluorescent lamp for 10h in ultra-pure water. The results indicate the formation of carbonyl functional groups and partial elimination of amine groups in the molecular structure of the oxidized CS-ECH film. This oxidized CS-ECH film has different optical properties, ionic conductivity, degree of transparency, swelling index and chemical stability than the fresh CS-ECH film. In the environmental applications, the TiO2/oxidized-CS-ECH photocatalyst system can have photodegradation and faster mineralization rate of phenol than both fresh TiO2/CS-ECH and TiO2/oxidized-CS photocatalyst systems. This simple photocatalyst system, therefore can be considered as an environmental friendly method to oxidize synthetic biopolymer and to improve the photocatalytic efficiency of TiO2 to treat wastewater.
    Matched MeSH terms: Epichlorohydrin/analogs & derivatives*; Epichlorohydrin/chemistry
  7. Jawad AH, Azharul Islam M, Hameed BH
    Int J Biol Macromol, 2017 Feb;95:743-749.
    PMID: 27914966 DOI: 10.1016/j.ijbiomac.2016.11.087
    Fabrication of an immobilized cross-linked chitosan-epichlorohydrine thin film (CLCETF) onto glass plate for adsorption of reactive orange 16 (RO16) dye was successfully studied using the direct casting technique. Adsorption experiments were performed as a function of contact time, initial dye concentration (25mg/L to 350mg/L), and pH (3-11). The adsorption isotherm followed the Langmuir model. The adsorption capacity of CLECTF for RO16 was 356.50mg/g at 27±2°C. The kinetics closely followed the pseudo-second-order model. Results supported the potential use of an immobilized CLECTF as effective adsorbent for the treatment of reactive dye without using filtration process.
    Matched MeSH terms: Epichlorohydrin/chemistry
  8. Salleh KM, Zakaria S, Gan S, Baharin KW, Ibrahim NA, Zamzamin R
    Int J Biol Macromol, 2020 Apr 01;148:11-19.
    PMID: 31893531 DOI: 10.1016/j.ijbiomac.2019.12.240
    Dissolved oil palm empty fruit bunch cellulose (EFBC) and sodium carboxymethylcellulose (NaCMC) were chemically crosslinked with epichlorohydrin (ECH) to generate designated hydrogel. After swelling process in distilled water, the swollen hydrogel was frozen and freeze-dried to form cryogel. The swelling phenomenon of hydrogel during the absorption process gave substantial effects on thinning of crosslinked network wall, pore size and volume, steadiness of cryogel skeletal structure, and re-swelling of cryogel. The swelling effects on hydrogel were confirmed via microscopic study using variable pressure scanning electron microscope (VPSEM). From the retrieved VPSEM images, nano-thin crosslinked network wall of 24.31 ± 1.97 nm and interconnected pores were observed. As a result, the amount of water, the swelling degree, and the freeze-drying process indirectly affected the VPSEM images that indicated pore size and volume, formation of interconnected pores, and re-swelling of cryogel. This study determined the intertwined factors that affected both hydrogel and cryogel properties by investigating the swelling phenomenon and its ensuing effects.
    Matched MeSH terms: Epichlorohydrin/chemistry
  9. Jawad AH, Abdulhameed AS, Reghioua A, Yaseen ZM
    Int J Biol Macromol, 2020 Nov 15;163:756-765.
    PMID: 32634511 DOI: 10.1016/j.ijbiomac.2020.07.014
    In this research, an attempt to develop zwitterion composite adsorbent is conducted by modifying chitosan (CHS) with a covalent cross-linker (epichlorohydrin, ECH) and an aluminosilicate mineral (zeolite, ZL). The zwitterion composite adsorbent of chitosan-epichlorohydrin/zeolite (CHS-ECH/ZL) is performed multifunctional tasks by removing two structurally different cationic (methylene blue dye, MB), and anionic (reactive red 120 dye, RR120) dyes from aqueous solutions. The surface property, crystallinity, morphology, functionality, and charge of the CHS-ECH/ZL are analyzed using BET, XRD, SEM, FTIR, and pHpzc, analyses, respectively. The influence of pertinent parameters namely CHS-ECH/ZL dosage (0.02-0.5 g), solution pH (4-10), temperature (303-323K), initial dye concentration (30-400 mg/L), and contact time (0-600 min) on the MB and RR120 removal are tested. The research findings revealed that the adsorption isotherm at equilibrium well explained in according to the Freundlich isotherm model, and the recorded adsorption capacities of CHS-ECH/ZL are 156.1 and 284.2 mg/g for MB and RR120 respectively at 30 °C. The mechanism of MB and RR120 adsorption onto the CHS-ECH/ZL indicates various types of interactions namely, electrostatic interaction, hydrogen bonding, and Yoshida H-bonding in addition to n-π interaction. Overall, this research introduces CHS-ECH/ZL composite as an eco-friendly zwitterion adsorbent with good applicability towards the two structurally different cationic and anionic dyes from aqueous environment.
    Matched MeSH terms: Epichlorohydrin
  10. Gull N, Khan SM, Butt OM, Islam A, Shah A, Jabeen S, et al.
    Int J Biol Macromol, 2020 Nov 01;162:175-187.
    PMID: 32562726 DOI: 10.1016/j.ijbiomac.2020.06.133
    Inflammation is a key challenge in the treatment of chronic diseases. Spurred by topical advancement in polymer chemistry and drug delivery, hydrogels that release a drug in temporal, spatial and dosage controlled fashion have been trendy. This research focused on the fabrication of hydrogels with controlled drug release properties to control inflammation. Chitosan and polyvinyl pyrrolidone were used as base polymers and crosslinked with epichlorohydrin to form hydrogel films by solution casting technique. Prepared hydrogels were analyzed by swelling analysis in deionized water, buffer and electrolyte solutions and gel fraction. Functional groups confirmation and development of new covalent and hydrogen bonds, thermal stability (28.49%) and crystallinity were evaluated by FTIR, TGA and WAXRD, respectively. Rheological properties including gel strength and yield stress, elasticity (2309 MPa), porosity (75%) and hydrophilicity (73°) of prepared hydrogels were also evaluated. In vitro studies confirmed that prepared hydrogels have good biodegradability, excellent antimicrobial property and admirable cytotoxicity. Drug release profile (87.56% in 130 min) along with the drug encapsulation efficiency (84%) of prepared hydrogels was also studied. These results paved the path towards the development of hydrogels that can release the drugs with desired temporal patterns.
    Matched MeSH terms: Epichlorohydrin/chemistry
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