MyMedR

Fulltext Ulcerative keratomycosis--case reports on three different species of fungi

Sukumaran K

Med J Malaysia, 1991 Dec;46(4):388-91.

Three clinical cases of fungal corneal ulcers are described to highlight the course, ocular morbidity and principles of treatment. A brief discussion of the diagnosis and management of ulcerative keratomycosis is presented.

Matched MeSH terms: Corneal Ulcer/microbiology*; Corneal Ulcer/therapy

Fulltext Fusarium solani keratitis. First report from Malaysia

Singh H, Jamal F, Marahakim MN, Chin CS

Med J Malaysia, 1981 Jun;36(2):89-91.

PMID: 7343825

The first culture-proven case zn Malaysia of fungal keratitis, due to Fusarium solani, is presented, followed by a brief discussion of mycotic keratitis.

Matched MeSH terms: Corneal Ulcer/microbiology*

Hypopyon cornea ulcer in Malaya; a hazard particularly of the rubber industry

McPHERSON HJ

Med J Malaya, 1954 Jun;8(4):318-29.

PMID: 13193269

Matched MeSH terms: Corneal Ulcer*

Mycotic Keratitis

Ong B, Rose L

Med J Malaya, 1965 Sep;20(1):84-5.

PMID: 4221439

Matched MeSH terms: Corneal Ulcer/diagnosis*

Fulltext Contact lens--related corneal ulcer: a two-year review

Goh PP, Shamala R, Chandamalar S, Tai XY, National Eye Database Study Group

Med J Malaysia, 2010 Jun;65 Suppl A:120-3.

PMID: 21488471

To create a national registry of contact-lens related corneal ulcers (CLRCU) patients in Malaysia with the aim of detecting outbreaks, identifying pattern of causative organisms, determining patient demography, risk factors, wearing patterns and monitoring outcome of treatment. The CLRCU registry is an ongoing patient registry established in 2007 as a surveillance tool used by Malaysian Ministry of Health ophthalmology departments. Notification of patients clinically suspected of CLRCU was performed online through the National Eye Database (NED). Data collected included patient demography, contact lens type, causative organism and treatment outcome. During 2007-2008, a total of 202 patients were notified to the CLRCU registry with a mean age of 26.7 years (71.8% female). All registered patients wore soft contact lens and monthly disposable lenses were the most popular (83.5%). The majority of patients had bacterial CLRCU and the most common causative organism was Pseudomonas (79.7% of bacterial cases). No epidemics were identified during the period of data examination. Use of contact lenses, which is increasing during modern times, may lead to CLRCU as a severe complication. The CLRCU registry is an effective tool which uses a web-based notification system that allows quick and up to date reports of CLRCU cases. This provides the ability to monitor outbreaks of disease and identify important causative and associated factors of the disease which may be used to reduce future incidence.

Matched MeSH terms: Corneal Ulcer/etiology*; Corneal Ulcer/microbiology; Corneal Ulcer/epidemiology

Actinomycetic corneal ulcer

Singh M, Kaur B

Eye (Lond), 1989;3 ( Pt 4):460-2.

PMID: 2606221

A rare case of keratoactinomycosis developing in the absence of any known ocular trauma is described. It showed a dramatic response to penicillin therapy. Steroids should be cautiously used in the presence of active corneal disease. This case highlights the importance of repeated examination of corneal scrapings.

Matched MeSH terms: Corneal Ulcer/drug therapy; Corneal Ulcer/etiology*; Corneal Ulcer/microbiology

Fulltext Multifacet of Cornea Patch Graft in Anterior Segment Diseases

Chendran P, Meng Hsien Y, Wan Abdul Halim WH

Case Rep Ophthalmol Med, 2019;2019:6862487.

PMID: 31885979 DOI: 10.1155/2019/6862487

Incidence of cornea melting or perforation is commonly seen in variety of cornea conditions. It can cause debilitating vision loss and impair patient's daily activity. Several techniques have been described to surgically treat cornea perforation and melting. In this article, a series of corneal diseases treated with corneal patch graft are highlighted to relate different approach of cornea patch graft surgery. Post-operative management and complications are discussed.

Matched MeSH terms: Corneal Ulcer

Fulltext Retrospective review of corneal ulcers in Ipoh Hospital

Kursiah MR, Sharif FM, Balaravi P

Med J Malaysia, 2008 Dec;63(5):391-4.

PMID: 19803298 MyJurnal

This study was a retrospective study on corneal ulcer of one year period in Hospital Ipoh. A total of 28 cases were studied. Among the risk factors identified were foreign body on cornea, trauma, contact lens, vernal keratoconjunctivitis and surgical complication. The nature of this disease which was severe and slow healing caused prolonged hospital admission. Identification of causative microorganism by corneal scraping help in the treatment and management of this condition.

Matched MeSH terms: Corneal Ulcer/diagnosis*; Corneal Ulcer/microbiology*; Corneal Ulcer/therapy

Bilateral simultaneous infectious keratitis secondary to contact lens wear: an unusual case report with rare organisms

Ali NA, Reddy SC

Eye Contact Lens, 2007 Nov;33(6 Pt 1):338-40.

PMID: 17993833

PURPOSE: To report an unusual case of bilateral simultaneous hypopyon corneal ulcer in a contact lens wearer caused by polymicrobial infection with rare organisms.
METHODS: A case report of a 21-year-old soft contact lens wearer, who visited the emergency department with a 3-day history of pain, redness, decreased vision, photophobia, and tearing in both eyes. Examination showed a central corneal ulcer with hypopyon in both eyes. The cultures from corneal scrapings of both eyes, the contact lenses, and the contact lens solution showed heavy growth of Pseudomonas aeruginosa, Alkaligenes species, and Flavobacterium meningosepticum.
RESULTS: The corneal ulcers healed completely with aggressive antibiotic treatment for 4 weeks. The best-corrected visual acuity after 6 months of follow-up was 20/400 in the right eye and 20/60 in the left eye.
CONCLUSIONS: The possibility of infectious keratitis should be kept in mind for an acute red eye in contact lens wearers, and appropriate initial management is essential for a successful outcome. It is believed that this is the first report of Flavobacterium meningosepticum as a causative organism in contact lens-related keratitis.

Matched MeSH terms: Corneal Ulcer/etiology; Corneal Ulcer/pathology; Corneal Ulcer/physiopathology

Fulltext Cyphellophora sp. Isolated from a Corneal Ulcer in the Human Eye

Rajandran S, Razali KM, Mustapha M, Palaniappan PA, Amran F

Case Rep Ophthalmol Med, 2020;2020:5861258.

PMID: 32774963 DOI: 10.1155/2020/5861258

Cyphellophora is a black yeast-like fungus with most of the strains being isolated from soil and plants. It tends to cause sooty blotch and flyspeck disease in plants. In humans, it is known to cause superficial skin and nail infections. This report highlights the case of a patient who initially presented with a small corneal abrasion which rapidly progressed into a corneal ulcer after the patient did not respond to the initial conventional treatment. The laboratory results from the corneal scraping found it to be Cyphellophora sp.

Matched MeSH terms: Corneal Ulcer

Reddy SC, Tajunisah I

Ann Ophthalmol (Skokie), 2008;40(1):39-44.

PMID: 18556981

Fifty-six contact lens-related corneal ulcers (central in 32; hypopyon in 24 and stromal abscess in 6) were studied. Culture was positive in 78.9%. Corneal ulcers healed with intense antibiotic therapy in nearly all patients. Increased awareness of lens care/disinfection and frequent replacement of storage cases and solution, and early detection of pathogens and intensive appropriate antibiotic therapy are key points in management.

Matched MeSH terms: Corneal Ulcer/drug therapy; Corneal Ulcer/microbiology*

Recurrence of peripheral ulcerative keratitis on the corneoscleral button in a young man treated successfully with oral corticosteroids

Wahid WA, Selvaraja V, Bakiah S, Ibrahim M

Cornea, 2008 Aug;27(7):837-9.

PMID: 18650673 DOI: 10.1097/ICO.0b013e318169d6cc

To describe recurrent peripheral ulcerative keratitis (PUK) on the corneoscleral graft in a young man treated successfully with oral corticosteroids.

Matched MeSH terms: Corneal Ulcer/prevention & control*; Corneal Ulcer/surgery

Sivaraj R, Verghese I, Lai YK, Parasakthi N

Family Physician, 1994;6:18-20.

Contact lenses provide an alternative to spectacles for many people. However, the hazard of bacterial corneal ulcers exists. This article describes a soft contact lens wearer who developed a bacterial corneal ulcer. Prompt diagnosis and treatment is essential for eradication of the infection and prevention of loss of vision.

Matched MeSH terms: Corneal Ulcer

Fulltext Kingella kingae Keratitis in a Child with Underlying Vernal Keratoconjunctivitis

Nurul-Laila S, Chai KS, Liza-Sharmini AT, Shatriah I

Case Rep Ophthalmol Med, 2017;2017:1087821.

PMID: 28546880 DOI: 10.1155/2017/1087821

Kingella kingae had rarely been reported as a causative organism for corneal ulcer and had not been described before in vernal keratoconjunctivitis (VKC). Generally regarded as commensals of respiratory tract particularly in young children, it had however been isolated from the corneal ulcer scraping of both adult and children. We report a case of bacterial ulcer with isolation of Kingella kingae from the corneal scraping in a young child with underlying VKC.

Matched MeSH terms: Corneal Ulcer

Topical piperacillin/tazobactam for recalcitrant pseudomonas aeruginosa keratitis

Chew FL, Soong TK, Shin HC, Samsudin A, Visvaraja S

J Ocul Pharmacol Ther, 2010 Apr;26(2):219-22.

PMID: 20415627 DOI: 10.1089/jop.2009.0077

To report the treatment of therapy-resistant Pseudomonas aeruginosa keratitis with topical piperacillin/tazobactam.

Matched MeSH terms: Corneal Ulcer/drug therapy*; Corneal Ulcer/physiopathology

Hemorrhagic Descemet Membrane Detachment Following Syphilitic Interstitial Keratitis

Höllhumer R, Zairani Mz A, Watson S

Cornea, 2016 Sep;35(9):1255-6.

PMID: 27227396 DOI: 10.1097/ICO.0000000000000889

PURPOSE: Syphilitic interstitial keratitis is a stromal inflammatory disease with characteristic secondary vascularization. This case illustrates a late complication of hemorrhagic Descemet membrane detachment.

METHODS: Case report.

RESULTS: The patient presented with painless sudden visual loss and progressive shallowing of the anterior chamber caused by hemorrhagic Descemet membrane detachment. She had corneal neovascularization and a positive syphilis serology. Owing to the risk of pupil block glaucoma, the patient had surgical drainage of the blood via an ab externo approach.

CONCLUSIONS: This case illustrates a previously unreported complication of syphilitic interstitial keratitis. The patient recovered good visual acuity and had residual pigment deposits in the pre-Descemet interface.

Matched MeSH terms: Corneal Ulcer/diagnosis; Corneal Ulcer/microbiology*; Corneal Ulcer/therapy

Fulltext Contact lens related Elizabethkingia meningoseptica keratitis-a first Southeast ASEAN case report & literature review

Ang, Wen-Jeat, Embong Zunaina, Raja Omar Raja Norliza, Abdul Jalil Fadzillah

Journal of Biomedical and Clinical Sciences, 2017;2(1):1-4.

MyJurnal

We describe the first clinical case of contact lens related corneal ulcer caused by Elizabethkingia meningosepticaregistered in Southeast Asia. A 20-year-old female student who wasa regular soft contact lens wearer, presented with pain, photophobia and blurring of vision of the right eye for 3 days. On slit lamp examination, there was a small paracentral anterior stromal infiltrate with an overlying epithelial defect. Microbiological cultures from corneal scrapings, contact lens and its casing were positive for E.meningoseptica. Due to high likelihood of contact lens contamination causing keratitis, topical fortified gentamicin0.9% and ceftazidime 5% were administered empirically. Topical vancomycin 5% was later added tailoring to the culture and sensitivity of the organism. After 8 weeks of treatment, the keratitis subsided and corneal epithelial defect completely healed with residual corneal opacity. Even though uncommon, contact lens related E.meningosepticakeratitis can occur in healthy immunocompetent individuals with no ocular comorbidities.

Matched MeSH terms: Corneal Ulcer

Fulltext Gelam honey promotes ex vivo corneal fibroblasts wound healing

Md Yusof A, Abd Ghafar N, Kamarudin TA, Chua KH, Azmi MF, Ng SL, et al.

Cytotechnology, 2019 Dec;71(6):1121-1135.

PMID: 31606844 DOI: 10.1007/s10616-019-00349-8

This study evaluated the effects of Gelam honey (GH) on ex vivo corneal fibroblast ulcer model via wound healing assay, gene expression and immunocytochemistry. Corneal fibroblasts from New Zealand white rabbits were culture expanded. The corneal fibroblast wound healing capacity was observed by creating a circular wound onto confluent monolayer cells cultured in basal medium (BM), BM with GH, serum-enriched basal medium (BMS) and BMS with GH respectively. Wound healing assay and phenotypic characterization of the corneal fibroblast were performed at different stages of wound closure. Expression of aldehyde dehydrogenase (ALDH), vimentin, α-smooth muscle actin (α-SMA), lumican, collagen I and matrix metalloproteinase 12 (MMP 12) were measured at day 1, day 3 and complete wound closure day. Corneal fibroblast cultured in BMS with GH demonstrated the fastest wound closure, at day 5 post wounding. The gene expressions of ALDH and vimentin were higher than control groups while α-SMA expression was lower, in GH enriched media. The expressions of lumican, collagen I and MMP 12 were also higher in cells cultured in GH enriched media compared to the control groups. GH was shown to promote in vitro corneal fibroblast wound healing and may be a potential natural adjunct in the treatment of corneal wound.

Matched MeSH terms: Corneal Ulcer

Fulltext Refractory Scedosporium apiospermum Keratitis Successfully Treated with Combination of Amphotericin B and Voriconazole

Fadzillah MT, Ishak SR, Ibrahim M

Case Rep Ophthalmol Med, 2013;2013:413953.

PMID: 23509650 DOI: 10.1155/2013/413953

Aim. To report a case of refractory fungal keratitis caused by Scedosporium apiospermum. Methods. Interventional case report. Results. A 47-year-old Malay housewife presented with left eye cornea ulcer as her first presentation of diabetes mellitus. There was no history of ocular trauma, contact lens used, or cornea foreign body. Scedosporium apiospermum was isolated from the cornea scrapping. Her cornea ulcer initially responded well to topical Amphotericin B within 3 days but subsequently worsened. Repeat cornea scrapping also yields Scedosporium apiospermum. This refractory keratitis was successfully treated with a combination of topical Amphotericin B and Voriconazole over 6 weeks. Conclusion. Scedosporium apiospermum keratitis is an opportunistic infection, which is difficult to treat despite tight control of diabetes mellitus and intensive antifungal treatment. The infection appeared to have very quick onset but needed long duration of treatment to completely heal. Surgical debridement always plays an important role as a therapeutic procedure as well as establishes the diagnosis through repeat scrapping.

Matched MeSH terms: Corneal Ulcer

Fulltext Acacia honey accelerates in vitro corneal ulcer wound healing model

Abd Ghafar N, Ker-Woon C, Hui CK, Mohd Yusof YA, Wan Ngah WZ

BMC Complement Altern Med, 2016 Jul 29;16:259.

PMID: 27473120 DOI: 10.1186/s12906-016-1248-0

BACKGROUND: The study aimed to evaluate the effects of Acacia honey (AH) on the migration, differentiation and healing properties of the cultured rabbit corneal fibroblasts.

METHODS: Stromal derived corneal fibroblasts from New Zealand White rabbit (n = 6) were isolated and cultured until passage 1. In vitro corneal ulcer was created using a 4 mm corneal trephine onto confluent cultures and treated with basal medium (FD), medium containing serum (FDS), with and without 0.025 % AH. Wound areas were recorded at day 0, 3 and 6 post wound creation. Genes and proteins associated with wound healing and differentiation such as aldehyde dehydrogenase (ALDH), vimentin, alpha-smooth muscle actin (α-SMA), collagen type I, lumican and matrix metalloproteinase 12 (MMP12) were evaluated using qRT-PCR and immunocytochemistry respectively.

RESULTS: Cells cultured with AH-enriched FDS media achieved complete wound closure at day 6 post wound creation. The cells cultured in AH-enriched FDS media increased the expression of vimentin, collagen type I and lumican genes and decreased the ALDH, α-SMA and MMP12 gene expressions. Protein expression of ALDH, vimentin and α-SMA were in accordance with the gene expression analyses.

CONCLUSION: These results demonstrated AH accelerate corneal fibroblasts migration and differentiation of the in vitro corneal ulcer model while increasing the genes and proteins associated with stromal wound healing.

Matched MeSH terms: Corneal Ulcer/metabolism*

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