MyMedR

The treatment of eosinophilic lung (tropical eosinophilia) with Hetrazan (a preliminary report)

Danaraj TJ

Proceedings of the Alumni Association of Malaya, 1956;9:172-187.

Matched MeSH terms: Eosinophilia

Webb JKG

The Indian Journal of Pediatrics, 1960;27:147-157.

1. The pathological changes in the lung, liver and lymph-nodes of typical cases of tropical pulmonary eosinophilia are described. 2. Microfilariae have been demonstrated in the centre of nodules in each of these tissues, suggesting that direct invasion by these organisms is the cause of the lesion in this disease. 3. Cases have been encountered with lymph-node and hepatic, but without lung involvement. The lesions in these cases are similar to those seen in the lung, and microfilariae are present. A plea is made to enlarge the concept of tropical eosinophilia to include such cases, and the same time to restrict it to those in which a filarial infection is proved or suspected. 4. Microfilariae recovered from lymph-nodes have been provisionally identified as W. bancrofti-type, but on the analogy of findings in Malaya, it is suggested that these may be of animal origin and that zoonotic filariasis remains the most likely explanation of tropical eosinophilia. © 1960 Dr. K C Chaudhuri Foundation.

Matched MeSH terms: Eosinophilia; Eosinophilia/etiology

The filarial complement fixation test in eosinophilic lung (a preliminary report)

Danaraj TJ, D'Silva LS, Schacher JF

Proceedings of the Alumni Association of Malaya, 1957;10:109-116.

Matched MeSH terms: Eosinophilia

Tropical eosinophilia; some atypical cases of clinical interest

D'ABRERA VS

Med J Malaya, 1958 Mar;12(3):559-62.

PMID: 13565029

Matched MeSH terms: Eosinophilia*

Fulltext Cryptogenic pulmonary eosinophilia--a case report

Zainudin BM, Ismail O

Singapore Med J, 1990 Dec;31(6):629-31.

PMID: 2281365

A 44-year-old Indian housewife presented with prolonged cough, intermittent fever, loss of weight and shortness of breath on exertion. Physical examination revealed a thin lady with fine crackles on both lungs. Marked eosinophilia and elevated erythrocyte sedimentation rate were noted on peripheral blood. Chest radiograph showed characteristic bilateral infiltrates affecting the periphery of both lungs. Treatment with corticosteroid resulted in dramatic improvement in symptoms, signs and radiographic changes within a few days.

Matched MeSH terms: Pulmonary Eosinophilia/diagnosis*; Pulmonary Eosinophilia/radiography

Tropical pulmonary eosinophilia [duplicate2]

Pallister RA

Trans R Soc Trop Med Hyg, 1951;44:756.

DOI: 10.1016/0035-9203(51)90012-0

Matched MeSH terms: Eosinophilia

The roentgenographic appearance of eosinophilic lung (tropical eosinophilia)

Khoo FY, Danaraj TJ

Am J Roentgenol Radium Ther Nucl Med, 1960 Feb;83:251-9.

PMID: 14408899

Matched MeSH terms: Eosinophilia/pathology*

Fulltext Kimura's disease: an unusual cause of cervical tumor

Asma A, Maizaton AA

Med J Malaysia, 2005 Aug;60(3):373-6.

PMID: 16379197

Kimura's disease (KD) is an angiolymphoid proliferative disease of soft tissue with peripheral blood eosinophilia and elevated serum immunoglobulin (Ig) E. The treatment options range from conservative observation for the asymptomatic patient to surgical excision, steroid therapy and radiotherapy for symptomatic patients. Surgical excision is the most common diagnostic measure and is the treatment of choice. A case of KD in a 13-year-old Malay girl is presented. Clinically there was painless right jugular digastric mass measuring 3cm by 3cm. Her blood investigation showed pronounced eosinophilia. She underwent excision biopsy uneventfully. The biopsy from the swelling showed reactive follicular hyperplasic with prominent eosinophilia. There was no evidence of malignant change. Postoperatively after 3 years follow up, she was asymptomatic and no signs of tumor recurrence.

Matched MeSH terms: Angiolymphoid Hyperplasia with Eosinophilia/complications*; Angiolymphoid Hyperplasia with Eosinophilia/pathology; Eosinophilia/etiology; Eosinophilia/pathology

Acquired platelet dysfunction with eosinophilia in white children

Poon MC, Ng SC, Coppes MJ

J Pediatr, 1995 Jun;126(6):959-61.

PMID: 7776107

Acquired platelet dysfunction associated with eosinophilia has been described mainly in indigenous Southeast Asian and East Indian children. We describe two white boys in whom this disorder developed after they had lived in Malaysia for 12 to 18 months. Acquired platelet dysfunction associated with eosinophilia should therefore be considered in children who, after a visit to this region, have easy bruising and esoinophilia.

Matched MeSH terms: Eosinophilia/complications*; Eosinophilia/epidemiology

Eosinophilic gastroenteritis

Eravelly J, Ho Hon Fah, Wong Wai Ping

Med J Malaya, 1967 Dec;22(2):130-5.

PMID: 4231978

Matched MeSH terms: Eosinophilia/complications*

Schultz-Dale reaction with sera of eosinophilic lung patients--a preliminary report

Guest MF, Wong MM

Med J Malaya, 1965 Dec;20(2):146-8.

PMID: 4159506

Matched MeSH terms: Pulmonary Eosinophilia/immunology*

Intestinal helminths in relation to eosinophilic lung (tropical eosinophilia) in Singapore

Schacher JF, Danaraj TJ

Am J Trop Med Hyg, 1960 Nov;9(6):616-9.

PMID: 13747131

The above survey based on a study of single stool specimens from 569 patients, drawn from a hospital population belonging to different ethnic groups and having different cultural backgrounds, failed to indicate an association between intestinal helminth infection and eosinophilic lung. The higher prevalence of eosinophilic lung in Indians than in the other ethnic groups, as reported previously, cannot be explained on a basis of differences in the prevalence of the intestinal helminths, Ascaris lumbricoides, hookworm, Trichuris trichiura and Strongyloides stercoralis.

Matched MeSH terms: Eosinophilia/complications*

Association between eosinophilia and lymphocytosis with functional outcomes of patients with Hirschsprung disease following transabdominal Yancey-Soave pull-through

Zakiyah AN, Prasetyo KR, Puspitawati I, Makhmudi A, Gunadi

Med J Malaysia, 2024 Aug;79(Suppl 4):6-11.

PMID: 39215408

INTRODUCTION: Hirschsprung disease (HSCR) is a disorder caused by the failure of neural crest migration leading to an aganglionic colon and functional obstruction. Transabdominal Yancey-Soave pull-through is one of the definitive therapies for this condition. Prognostic factors, including sex, aganglionosis type, age at definitive surgery, nutritional status, eosinophilia and lymphocytosis, might influence the outcomes of the pull-through. We evaluated the functional outcomes of HSCR patients after Yancey- Soave surgery and associated them with the prognostic factors.

MATERIALS AND METHODS: The study included Hirschsprung patients aged ≥3 and <18 years who underwent Yancey- Soave surgery at our hospital. The functional outcomes were evaluated using the Krickenbeck classification to determine voluntary bowel movement (VBM), constipation and soiling.

RESULTS: Most (82.6%) patients showed VBM, 26.1% had constipation and 4.3% suffered from soiling. Among 23 patients who received Yancey-Soave surgery, 8 (34.8%) had eosinophilia and 5 (21.7%) had lymphocytosis. However, no significant differences were observed between eosinophilia and non-eosinophilia groups for VBM (p=1.0), constipation (p= 0.621) or soiling (p=0.738). Similarly, no significant differences were found between lymphocytosis and nonlymphocytosis groups for VBM (p=1.0), constipation (p=0.545) or soiling (p=0.973). Moreover, no other prognostic factors affected the functional outcomes after Yancey- Soave surgery (p>0.05).

CONCLUSION: Our study shows that eosinophilia and lymphocytosis might not affect the functional outcome of patients with HSCR following Yancey-Soave surgery. In addition, sex, aganglionosis type, age at definitive surgery and nutritional status might not influence the functional outcome after definitive surgery. Further, a more extensive study is essential to clarify our findings.

Matched MeSH terms: Eosinophilia*

Fulltext Kimura's disease in Malay patients

Shahrul H, Baharudin A, Effat O

Med J Malaysia, 2007 Aug;62(3):263-4.

PMID: 18246925 MyJurnal

Kimura's Disease (KD) is an uncommon, chronic inflammatory disorder of unknown etiology which is endemic in Orientals. It is characterized by painless, large solitary or multiple nodules in subcutis of head and neck region or the major salivary glands, associated with regional lymphadenopathy, blood eosinophilia and elevated IgE levels. Its treatment ranging from conservative observation in asymptomatic patient to surgical resection of the mass, corticotherapy and irradiation therapy for the symptomatic ones.

Matched MeSH terms: Angiolymphoid Hyperplasia with Eosinophilia/diagnosis; Angiolymphoid Hyperplasia with Eosinophilia/physiopathology*; Angiolymphoid Hyperplasia with Eosinophilia/therapy

Fulltext Traumatic ulcerative granuloma with stromal eosinophilia - Mystery of pathogenesis revisited

Sarangarajan R, Vaishnavi Vedam VK, Sivadas G, Sarangarajan A, Meera S

J Pharm Bioallied Sci, 2015 Aug;7(Suppl 2):S420-3.

PMID: 26538890 DOI: 10.4103/0975-7406.163474

Oral ulcers are a common symptom in clinical practice. Among various causative factors, different types of ulcers in oral cavity exist. Among this, traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) appears to be quite neglected by the clinicians due to the limited knowledge and awareness. On reviewing with a detailed approach to titles and abstracts of articles eliminating duplicates, 40 relevant articles were considered. Randomized studies, review articles, case reports and abstracts were included while conference papers and posters were excluded. Of importance, TUGSE cases been reported only to a minimal extent in the literature. Lack of its awareness tends to lead clinicians to a misconception of cancer. Thus, this particular lesion needs to be differentiated from other malignant lesions to provide a proper mode of treatment. The present article reviews various aspects of the TUGSE with emphasis on the clinical manifestation, pathogenesis, histological, and immunohistochemical study. This study provides the clinician contemporaries, a humble expansion to their knowledge of the disease, based on the searched literature, enabling a more comprehensive management of this rare occurrence.

Matched MeSH terms: Eosinophilia

Fulltext Kimura's Disease: Diagnostic Challenge and Treatment Modalities

Sia KJ, Kong CK, Tan TY, Tang IP

Med J Malaysia, 2014 Dec;69(6):281-3.

PMID: 25934961

CASE REPORT: Five cases of Kimura's disease had been treated in our centre from year 2003 to 2010. All cases were presented with head and neck mass with cervical lymphadenopathy. Surgical excision was performed for all cases. Definite diagnosis was made by histopathological examination of the resected specimens. One out of five cases developed tumour recurrence four years after resection.

CONCLUSION: Surgical excision is our choice of treatment because the outcome is immediate and definite tissue diagnosis is feasible after resection. Oral corticosteroid could be considered as an option in advanced disease. However, tumour recurrence is common after cessation of steroid therapy.

Matched MeSH terms: Angiolymphoid Hyperplasia with Eosinophilia

Cor pulmonale: an unusual presentation of tropical eosinophilia

Quah BS, Anuar AK, Rowani MR, Pennie RA

Ann Trop Paediatr, 1997 Mar;17(1):77-81.

PMID: 9176582

Tropical pulmonary eosinophilia (TPE) is considered to be a variant of human filarial infection. The pulmonary manifestations of TPE have been well described. Extra-pulmonary features of the disease, although not commonly seen, have been reported previously. A 9-year-old Malay girl with a history of recurrent cough and wheezing was admitted because of cardiac failure. Physical examination revealed a very sick girl with tachypnoea, central cyanosis, finger clubbing, elevated jugular venous pulse, generalized crackles and rhonchi in the chest, a loud second heart sound and hepatosplenomegaly. A chest radiograph showed cardiomegaly and right pleural effusion. Laboratory investigations revealed hypochromic, microcytic anaemia with persistent blood eosinophilia (absolute eosinophil counts varied from 1.9 to 5.5 x 10(9)/1). The ELISA test for antifilarial IgG antibodies was strongly positive. She responded promptly to treatment with diethylcarbamazine. In summary, this is a patient with TPE who presented with cor pulmonale, probably due to late-stage interstitial pulmonary fibrosis. In order to prevent the long term morbidity of cardiorespiratory disability, the early signs of TPE should be recognized and the infection treated.

Matched MeSH terms: Pulmonary Eosinophilia/complications*; Pulmonary Eosinophilia/diagnosis; Pulmonary Eosinophilia/therapy

Fulltext A case of Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss, EGPA) presenting with relapsed Mononeuritis multiplex

Hilmi, B.A., Ainon, M.M.

International Medical Journal Malaysia, 2014;13(1):69-72.

MyJurnal

We report a case of eosinophilic granulomatosis with polyangiitis (EGPA), a rare multisystem disorder characterized by difficult-to-control asthma, hypereosinophilia and polyneuropathy. We also discuss the Five Factor Score (FFS) risk stratification strategy, which is used to quantitate the extent of the disease and guide treatment strategy.

Matched MeSH terms: Eosinophilia

A rare case of inguinal kimura disease

Gregory X, Soon NI, Nur Aklina R

Med J Malaysia, 2018 10;73(5):326-327.

PMID: 30350814 MyJurnal

Kimura's disease is a rare chronic inflammatory disease of unknown etiology, commonly presenting with painless lymphadenopathy and subcutaneous masses in the head and neck regions.1 However, presentations with inguinal lymphadenopathy are rare and mimics other differentials, may pose a diagnostic challenge. We present a case of a 50-year-old male, with right inguinal swelling for one month duration that was finally diagnosed with Kimura's Disease after a multitude of investigations to rule out differentials of lymphadenopathy, delaying conclusive treatment. Specialized test had been done resonated with the histopathological findings only. We report this case to increase awareness of Kimura's Disease.

Matched MeSH terms: Angiolymphoid Hyperplasia with Eosinophilia

The etiology and pathology of eosinophilic lung (tropical eosinophilia)

Danaraj TJ, Pacheco G, Shanmugaratnam K, Beaver PC

Am J Trop Med Hyg, 1966 Mar;15.(2):183-9.

PMID: 5910525

The finding of microfilariae in lung tissue from patients with eosinophilic lung is reported and the histopathological appearances are described.

Matched MeSH terms: Eosinophilia/drug therapy; Eosinophilia/etiology; Eosinophilia/pathology

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