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Production and characterization of the defatted oil palm shell nanoparticles

Abdul Khalil HPS, Md. Sohrab Hossain, Nur Amiranajwa AS, Nurul Fazita MR, Mohamad Haafiz MK, Suraya N, et al.

Sains Malaysiana, 2016;45:833-839.

This present study was conducted to produce defatted oil palm shell (OPS) nanoparticles. Wherein, the OPS nanoparticles
were defatted by solvent extraction method. Several analytical methods including transmission electron microscope (TEM),
X-ray diffraction (XRD), particle size analyzer, scanning electron microscope (SEM), SEM energy dispersive X-ray (SEM-EDX)
and thermal gravimetric analyzer (TGA) were used to characterize the untreated and defatted OPS nanoparticles. It was
found that 75.3% OPS particles were converted into nanoparticles during ball milling. The obtained OPS nanoparticles had
smaller surface area with angular, irregular and crushed shapes under SEM view. The defatted OPS nanoparticles did not
show any agglomeration during TEM observation. However, the untreated OPS nanoparticles had higher decomposition
temperature as compared to the defatted OPS nanoparticles. Based on the characterization results of the OPS nanoparticles,
it is evident that the defatted OPS nanoparticles has the potentiality to be used as filler in biocomposites

Matched MeSH terms: Radiography
Reliability of panoramic-radiograph to determine the position of third-molar from inferior-alveolar-canal

Azizah Ahmad Fauzi, Mohamed Ebrahim Parker, Norval E., Phrabhakaran N

Sains Malaysiana, 2017;46:59-65.

Cone-beam-computed-tomography (CBCT) has been useful in providing insights of relevant anatomy prior to surgical
procedures, including the assessment of the proximity of impacted mandibular-third-molar to the inferior-alveolar-canal
(IAC). It is important to understand the reliability of conventional panoramic-radiograph in the assessment of this criterion
since it is more commonly used as first line radiographic approach due to its availability and lower radiation dose. This
study aimed to investigate the reliability of conventional panoramic-radiograph in the evaluation of the proximity of
impacted mandibular-third-molar root tip to the IAC by correlating the results with CBCT. A total of 65 root tips of impacted
mandibular-third-molars that had both panoramic radiographs and CBCT images were included in this retrospective study.
Two trained observers participated in all image evaluations. A prepared standard 1 cm ruler was used to measure the
proximity of the third-molar root apices to the IACs. Measurements recorded in this study were categorized into positive
(root apex above a roof of IAC), zero (root apex was superimposed on IAC) and negative (root apex below a roof of IAC).
Data analysis was carried out using student t-test. In this study, both observers recorded statistically significant differences
in the measurement between third-molars root apices and the IAC from panoramic radiographs and CBCT images. The low
reliability of panoramic radiograph to assess the vertical proximity between these two anatomical structures suggests
the importance of additional assessment with CBCT in cases where panoramic radiograph shows superimposition of the
third molar root on the roof of the canal and presence of root below the roof of the IAC.

Matched MeSH terms: Radiography, Panoramic
Sub kGy photon irradiation alterations in graphite

Bradley DA, Nawi SNM, Khandaker MU, Almugren KS, Sani SFA

Appl Radiat Isot, 2020 Jul;161:109168.
PMID: 32321700 DOI: 10.1016/j.apradiso.2020.109168

Present work concerns polymer pencil-lead graphite (PPLG) and the potential use of these in elucidating irradiation-driven structural alterations. The study provides detailed analysis of radiation-induced structural interaction changes and the associated luminescence that originates from the energy absorption. Thermally stimulated emission from the different occupied defect energy levels reflects the received radiation dose, different for the different diameter PPLGs. The PPLG samples have been exposed to photon irradiation, specifically x-ray doses ranging from 1 to 10 Gy, extended to 30-200 Gy through use of a60Co gamma-ray source. Trapping parameters such as order of kinetics, activation energy and frequency factor are estimated using Chen's peak-shape method for a fixed-dose of 30 Gy. X-ray diffractometry was used to characterize the crystal structure of the PPLG, the aim being to identify the degree of structural order, atomic spacing and lattice constants of the various irradiated PPLG samples. The mean atomic spacing and degree of structural order for the different diameter PPLG are found to be 0.3332 nm and 26.6° respectively. Photoluminescence spectra from PPLG arising from diode laser excitation at 532 nm consist of two adjacent peaks, 602 nm (absorption) and 1074 nm (emission), with mean energy band gap values within the range 1.113-1.133 eV.

Matched MeSH terms: Radiography
Fulltext Evaluation of Biological Pretreatment of Rubberwood with White Rot Fungi for Enzymatic Hydrolysis

Nazarpour F, Abdullah DK, Abdullah N, Zamiri R

Materials (Basel), 2013 May 15;6(5):2059-2073.
PMID: 28809260 DOI: 10.3390/ma6052059

e effects of biological pretreatment on the rubberwood (Hevea brasiliensis), was evaluated after cultivation of white rot fungi Ceriporiopsis subvermispora, Trametes versicolor, and a mixed culture of C. subvermispora and T. versicolor. The analysis of chemical compositions indicated that C. subvermispora had greater selectivity for lignin degradation with the highest lignin and hemicellulose loss at 45.06% and 42.08%, respectively, and lowest cellulose loss (9.50%) after 90 days among the tested samples. X-ray analysis showed that pretreated samples had a higher crystallinity than untreated samples. The sample pretreated by C. subvermispora presented the highest crystallinity of all the samples which might be caused by the selective degradation of amorphous components. Fourier transform infrared (FT-IR) spectroscopy demonstrated that the content of lignin and hemicellulose decreased during the biological pretreatment process. A study on hydrolysis of rubberwood treated with C. subvermispora, T. versicolor, and mixed culture for 90 days resulted in an increased sugar yield of about 27.67%, 16.23%, and 14.20%, respectively, as compared with untreated rubberwood (2.88%). The results obtained demonstrate that rubberwood is a potential raw material for industrial applications and white rot fungus C. subevermispora provides an effective method for improving the enzymatic hydrolysis of rubberwood.

Matched MeSH terms: Radiography
Fulltext Outcome of longstanding dislocated elbows treated by open reduction and excision of collateral ligaments

Devnani AS

Singapore Med J, 2004 Jan;45(1):14-9.
PMID: 14976577

To study the long term result of open reduction of longstanding dislocated elbows with regard to stability, avascular necrosis of the distal humerus and degenerative changes of the joint.

Matched MeSH terms: Elbow Joint/radiography; Humerus/radiography; Osteonecrosis/radiography
Fulltext Extramedullary plasmacytoma in the maxillary sinus

Megat Shiraz MA, Jong YH, Primuharsa Putra SH

Singapore Med J, 2008 Nov;49(11):e310-1.
PMID: 19037537

Extramedullary plasmacytoma is a rare malignant plasma cell tumour. We report an extremely aggressive case of extramedullary plasmacytoma of the right maxillary sinus, which had metastasised to the brain and rib. A 56-year-old man presented with recurrent epistaxis and acute anaemia. Nasendoscopy revealed a medialised medial wall of the right maxilla and a mass occupying the whole nasopharynx. Magnetic resonance imaging revealed a right maxillary tumour with extension to the ipsilateral nasal cavity, nasopharynx, right sphenoid and ethmoidal sinuses. There was an extra-axial brain metastasis. There were metastases to the right parietal region and left eighth rib. Histopathology examination of the maxillary mass revealed abundant plasma cells with kappa-chain restriction. He was planned for four cycles of chemotherapy. Unfortunately, in view of the advanced stage of disease, he succumbed to his disease during the first cycle of chemotherapy.

Matched MeSH terms: Maxillary Sinus/radiography; Maxillary Sinus Neoplasms/radiography*; Plasmacytoma/radiography
Fulltext Successful endovascular treatment of post-traumatic inferior pancreaticoduodenal artery pseudoaneurysm

Leong BD, Chuah JA, Kumar VM, Mazri MY, Zainal AA

Singapore Med J, 2008 Nov;49(11):e300-2.
PMID: 19037533

True and pseudoaneurysms of the visceral arteries are uncommon. They represent 0.1-0.2 percent of all vascular aneurysms. Visceral artery aneurysms (VAAs) should be treated due to their propensity to rupture and associated high mortality. We describe a 58-year-old man with pseudoaneurysm of the inferior pancreaticoduodenal artery and who presented with post-motor vehicle accident abdominal pain and a pulsatile epigastic mass. Computed tomography (CT) showed a pseudoaneurysm of the visceral artery, and selective mesenteric angiography showed the aneurysm to be arising from the inferior pancreaticoduodenal artery. The aneurysm was successfully treated with endovascular coil embolisation. CT angiogram at one month post-procedure revealed persistent occlusion of the aneurysm. To the best of our knowledge, this is the first reported pseudoaneurysm of inferior pancreaticoduodenal artery secondary to blunt abdominal trauma from a motor vehicle accident and also the first reported VAA from Malaysia.

Matched MeSH terms: Celiac Artery/radiography; Hepatic Artery/radiography; Mesenteric Artery, Superior/radiography
Fulltext An Analysis of the Clinical and Radiological Prognostic Factors Affecting the Outcomes of Lumbar Intradiscal Biacuplasty

Md MY, Md CG, Md CW, MSc YC, MSc HJ, Md IH, et al.

Int J Med Sci, 2023;20(8):1115-1122.
PMID: 37484806 DOI: 10.7150/ijms.85777

Purpose: Intradiscal biacuplasty (IDB) has been proven to be effective for treating lumbar degenerative disc disease (DDD). However, there has not been a reported prognostic factor for IDB. The present study meticulously evaluates the general and radiographic features that may serve as markers for predicting the therapeutic outcome of IDB. Methods: A prospective case series study was conducted, following time-series analysis moving averages models, with forty-one patients suffering from chronic discogenic lower back pain for more than six months. These patients subsequently received lumbar cool radiofrequency IDB and were enrolled in the study. Thirty-seven patients completed follow-up questionnaires at 1, 3, 6, and 12 months. The surgical outcomes were reported using visual analogue scale (VAS), Oswestry disability index (ODI), and the consumption of nonsteroidal anti-inflammatory drugs (NSAID). Furthermore, a univariate analysis was performed to identify prognostic factors associated with pain relief from age, gender, body mass index (BMI), and pre-operative lumbar magnetic resonance imaging reading. Results: Significant reductions were found in estimated VAS and ODI at the post-operative period at 1, 3, 6, and 12 months (P < 0.001). The NSAID dosage was significantly decreased at 3-month and 1-year follow-up (P < 0.05). No procedure-related complications were detected. The prognosis of IDB was not related to disc height, Pfirrmann grading or Modic endplate change. However, disc extrusions were associated with promising outcomes (VAS improvement ≥ 50%) on pain relief (P < 0.05). Conclusion: IDB is a good alternative choice for treating lumbar DDD. Patients with a painful extrusion lumbar disc may gain some benefits after receiving IDB following a period of failed conservative treatment. These findings may also add some references for physicians in the decision making when treating lumbar DDD.

Matched MeSH terms: Radiography
Fulltext Reliability and limitations of permanent tooth staging techniques

Abdul Rahim AH, Davies JA, Liversidge HM

Forensic Sci Int, 2023 May;346:111654.
PMID: 37011430 DOI: 10.1016/j.forsciint.2023.111654

Reliability, or repeatability, of permanent tooth staging techniques is usually expressed as Cohen's Kappa. This single value obscures information about the quantity and allocation of disagreements. In this study we assess and compare intra-observer reliability of permanent tooth staging techniques described by Nolla, Moorrees et al. and Demirjian et al. The sample was panoramic radiographs of healthy dental patients made up of 100 males and 100 females aged 6-15 years. All permanent teeth on the left side (excluding third molars) were scored twice. Weighted Kappa and percentage agreement were calculated. Results show Kappa values for all teeth combined as 0.918, 0.922 and 0.938 for Demirjian (number of teeth N = 2682), Nolla (N = 2698) and Moorrees (N = 2674) respectively. A comparison of Kappa values between upper and lower teeth showed marginally higher values for upper incisors and lower molar for all three scoring methods. Small differences in Kappa values were noted between tooth types with the upper first molar having smaller values than other teeth. Percentage agreement ranged from 81 % (Moorrees), 86 % (Nolla) to 87 % (Demirjian). Tooth stage differences between first and second assessments were not more than one stage. Our findings show that Demirjian scoring is marginally more reliable than Nolla or Moorrees. We suggest that (1) data for reliability are tabulated in full to show the quantity and allocation of disagreement between first and second readings, and (2) that the reliability sample is sufficiently large with a wide age range to include multiple different tooth stages.

Matched MeSH terms: Radiography, Panoramic
Radiological and Dosimetric Evaluation of Biomaterial Composite Phantoms with High Energy Photons and Electrons

Samson DO, Aziz MZA, Shukri A, Mat Jafri MZ, Hashim R, Zuber SH, et al.

Health Phys, 2023 Aug 01;125(2):77-91.
PMID: 36826380 DOI: 10.1097/HP.0000000000001688

The current study was undertaken to investigate the radiological and dosimetric parameters of natural product-based composite (SPI/NaOH/IA-PAE/ Rhizophora spp .) phantoms. The radiological properties of the phantoms were measured at different gamma energies from Compton scatter of photons through angles of 0, 30, 45, 60, 75, and 90 degrees. Ionization chamber (IC) and Gafchromic EBT3 film dosimeters were employed to evaluate the dosimetric characteristics for photons (6-10 MV) and electrons (6-15 MeV). Radiological property results of the composite phantoms were consistent with good quality compared to those of solid water phantoms and theoretical values of water. Photon beam quality index of the SPI15 phantom with p-values of 0.071 and 0.073 exhibited insignificant changes. In addition, good agreement was found between PDD curves measured with IC and Gafchromic EBT3 film for both photons and electrons. The computed therapeutic and half-value depth ranges matched within the limits and are similar to those of water and solid water phantoms. Therefore, the radiological and dosimetric parameters of the studied composite phantom permit its use in the selection of convenient tissue- and water-equivalent phantom material for medical applications.

Matched MeSH terms: Radiography
Assessment of patient and occupational exposure and radiation risk from cath-lab procedure

Sulieman A, Mahgoub O, Salah H, Tamam N, Taha A, Dawood S, et al.

Appl Radiat Isot, 2023 Dec;202:111071.
PMID: 37871398 DOI: 10.1016/j.apradiso.2023.111071

Due to the extended localized fluoroscopy, many radiographic exposures, and multiple procedures that might result in tissue reaction, patients and personnel received a significant radiation dose during interventional cardiology (IR) procedures. This study aims to calculate the radiation risk and assess patient and staff effective doses during IC procedures. Thirty-two patients underwent a Cath lab treatment in total. Ten Cath lab personnel, including six nurses, two cardiologists, and two X-ray technologists. Optical stimulating-luminescent dosimeters (OSL) (Al2O3:C) calibrated for this purpose were used to monitor both occupational and ambient doses. Using an automated OSL reader, these badges were scanned. The Air Kerma (mGy) and Kerma Area Products (KAP, mGy.cm2) have a mean and standard deviation (SD) of 371 ± 132 and 26052, respectively. The average personal dose equivalent (mSv) and its range for cardiologists, nurses and X ray technologists were 1.11 ± 0.21 (0.96-1.26), 0.84 ± 0.11 (0.68-1.16), and 0.68 ± 0.014 (0.12-0.13), respectively. The current study findings showed that the annual effective dose for cardiologists, nurses, and X-ray technologists was lesser than the yearly occupational dose limit of 20 mSv recommended by national and international guidelines. The patients' doses are comparable with some previously published studies and below the tissue reaction limits.

Matched MeSH terms: Radiography
Fatal anterior mediastinal mass in a pregnant lady

Koo ZP, Chainchel Singh MK, Mohamad Noor MHB, Omar NB, Siew SF

Forensic Sci Med Pathol, 2024 Mar;20(1):226-232.
PMID: 37436679 DOI: 10.1007/s12024-023-00669-4

We report a fatal case of a 26-year-old nulliparous woman who presented with an anterior mediastinal mass in her late pregnancy. She had complained of a progressively increasing neck swelling and occasional dry cough in the early second trimester, which was associated with worsening dyspnoea, reduced effort tolerance and orthopnoea. Ultrasound of the neck showed an enlarged lymph node, and chest X-ray revealed mediastinal widening. At 35 weeks' gestation, the patient was referred to a tertiary centre for a computed tomography (CT) scan of the neck and thorax under elective intubation via awake fibreoptic nasal intubation as she was unable to lie flat. However, she developed sudden bradycardia, hypotension and desaturation soon after being positioned supine, which required resuscitation. She succumbed after 3 days in the intensive care unit. An autopsy revealed a large anterior mediastinal mass extending to the right supraclavicular region, displacing the heart and lungs, encircling the superior vena cava and right internal jugular vein with tumour thrombus extending into the right atrium. Histopathology examination of the mediastinal mass confirmed the diagnosis of a primary mediastinal large B-cell lymphoma. This report emphasizes the severe and fatal outcome resulting from the delay and misinterpretation of symptoms related to a mediastinal mass.

Matched MeSH terms: Radiography
Fulltext Application of phase congruency for discriminating some lung diseases using chest radiograph

Rijal OM, Ebrahimian H, Noor NM, Hussin A, Yunus A, Mahayiddin AA

Comput Math Methods Med, 2015;2015:424970.
PMID: 25918551 DOI: 10.1155/2015/424970

A novel procedure using phase congruency is proposed for discriminating some lung disease using chest radiograph. Phase congruency provides information about transitions between adjacent pixels. Abrupt changes of phase congruency values between pixels may suggest a possible boundary or another feature that may be used for discrimination. This property of phase congruency may have potential for deciding between disease present and disease absent where the regions of infection on the images have no obvious shape, size, or configuration. Five texture measures calculated from phase congruency and Gabor were shown to be normally distributed. This gave good indicators of discrimination errors in the form of the probability of Type I Error (δ) and the probability of Type II Error (β). However, since 1 - δ is the true positive fraction (TPF) and β is the false positive fraction (FPF), an ROC analysis was used to decide on the choice of texture measures. Given that features are normally distributed, for the discrimination between disease present and disease absent, energy, contrast, and homogeneity from phase congruency gave better results compared to those using Gabor. Similarly, for the more difficult problem of discriminating lobar pneumonia and lung cancer, entropy and homogeneity from phase congruency gave better results relative to Gabor.

Matched MeSH terms: Radiography, Thoracic
Fulltext Recurrent bilateral occipital infarct with cortical blindness and anton syndrome

Kwong Yew K, Abdul Halim S, Liza-Sharmini AT, Tharakan J

Case Rep Ophthalmol Med, 2014;2014:795837.
PMID: 24744933 DOI: 10.1155/2014/795837

Bilateral cortical blindness and Anton syndrome, are most commonly caused by ischaemic stroke. In this condition, patients have loss of vision but deny their blindness despite objective evidence of visual loss. We report a case of a patient with multiple cardiovascular risk factors who developed recurrent bilateral occipital lobe infarct with Anton syndrome. A suspicion of this condition should be raised when the patient has denial of blindness in the presence of clinical and radiological evidence of occipital lobe injury. Management of this condition should focus on the underlying cause, in which our patient requires secondary stroke prevention and rehabilitation.

Matched MeSH terms: Radiography
Fulltext Accuracy of different dental age assessment methods to determine chronological age among children with special needs

Ismail AF, Adnan NH, Suhaidi NNS, Mokhtar IW, Yusof MYPM, Mallineni SK

J Indian Soc Pedod Prev Dent, 2024 Jan 01;42(1):64-70.
PMID: 38616429 DOI: 10.4103/jisppd.jisppd_47_24

AIM: This study aimed to validate the accuracy of dental age (DA) based on the dental development of permanent teeth in children with special needs using Demirjian, Willems, and London Atlas methods and to correlate the dental and chronological age (CA) of children with special needs in Malaysia.
MATERIALS AND METHODS: The panoramic radiographic images belonging to children with special needs from the two teaching dental hospitals in Malaysia aged between 5 and 16 years were included in the study. The evaluation was performed by two observers using three methods (London Atlas, Demirjian, and Willems methods) to estimate the accurate DA. The outcome was determined by comparing the mean of the DA and CA.
RESULTS: A total of 52 panoramic radiographs were available for the analysis. The London Atlas and Demirjian methods overestimated the DA with a mean of 0.05 and 0.20 years, respectively, while the Willems method underestimated by 0.19 years. The London Atlas method was highly precise and accurate, while Demirjian and Willems methods were the least precise and accurate.
CONCLUSION: The London Atlas method of DA estimation is highly accurate and valid for children with special needs in the Malaysian population, followed by the Willems and Demirjian methods.

Matched MeSH terms: Radiography, Panoramic
Factors influencing final year radiography students' intention to pursue postgraduate education in medical imaging

Mohamed A, Mat Sanusi NSA, Azman NS, Zailani NS, Jasmin NH, Che Isa IN

Radiography (Lond), 2024 Jan;30(1):388-393.
PMID: 38159357 DOI: 10.1016/j.radi.2023.12.006

INTRODUCTION: Postgraduate education in medical imaging is an important platform that can support in preparing radiographers for the role extension and advancement in radiography. Thus, this study aims to identify the factors influencing final year radiography students' intention to pursue postgraduate education in medical imaging.
METHODS: An online cross-sectional survey was conducted among final year students in medical imaging programs from six institutions in Malaysia. Purposive convenience sampling has been employed. Data collection was related to students' interest in postgraduate study and possible factors that may affect students' intention to pursue postgraduate education after study degree completion. The questionnaire was a combination of a Likert Scale and open-ended question.
RESULTS: A total of 148 (female, n = 132 and male, n = 16) responses were included in the analysis. Among the participants, n = 93 (62.8 %) of students intended to pursue study. The highest choice of study was mixed mode (41.9 %) and cardiac imaging was the field of choice by the students (22.3 %). Five factors have been found to significantly correlate with the students' intention to pursue postgraduate study in medical imaging which were student attributes, being an academician, remuneration, finance, and social influences (p 0.05).
CONCLUSION: Five out of seven factors tested were found to significantly influence students' decision to pursue postgraduate education in medical imaging. Effective strategies based on the influencing factors should be strategized to encourage more students to pursue postgraduate education in medical imaging.
IMPLICATIONS FOR PRACTICE: Implementation of effective strategies based on the influencing factors will improve access to education among radiography students, ultimately enhancing future radiographers' capability and competency.

Matched MeSH terms: Radiography
Localization and prediction of malignant potential in recurrent pheochromocytoma/paraganglioma (PCC/PGL) using 18F-FDG PET/CT

Fikri AS, Kroiss A, Ahmad AZ, Zanariah H, Lau WF, Uprimny C, et al.

Acta Radiol, 2014 Jun;55(5):631-40.
PMID: 24037430 DOI: 10.1177/0284185113504330

To our knowledge, data are lacking on the role of 18F-FDG PET/CT in the localization and prediction of neuroendocrine tumors, in particular the pheochromocytoma/paraganglioma (PCC/PGL) group.

Matched MeSH terms: Adrenal Gland Neoplasms/radiography*; Paraganglioma/radiography*; Pheochromocytoma/radiography*
Fulltext The vanishing veins: difficult venous access in a patient requiring translumbar, transhepatic, and transcollateral central catheter insertion

Yaacob Y, Zakaria R, Mohammad Z, Ralib AR, Muda AS

Malays J Med Sci, 2011 Oct;18(4):98-102.
PMID: 22589680

Central venous catheter placement is indicated in patients requiring long-term therapy. With repeated venous catheterisations, conventional venous access sites can be exhausted. This case illustrates the expanding role of radiology in managing difficult venous access. We present a case of translumbar, transhepatic, and transcollateral placement of central catheter in a woman with a difficult venous access problem who required lifelong parenteral nutrition secondary to short bowel syndrome. This case highlights the technical aspects of interventional radiology in vascular access management.

Matched MeSH terms: Radiography
Fulltext Treatment outcome of superficial cerebral abscess: an analysis of two surgical methods

Tan WM, Adnan JS, Mohamad Haspani MS

Malays J Med Sci, 2010 Jan;17(1):23-9.
PMID: 22135522 MyJurnal

The purpose of the study is to compare the two surgical methods (burr hole and craniotomy) used as treatment for superficial cerebral abscess and its outcome in terms of radiological clearance on brain CT, improvement of neurological status, the need for repeated surgery, and survival and morbidity at three months after surgery. This report is a retrospective case review of the patients who were treated surgically for superficial cerebral abscess in Hospital Kuala Lumpur (HKL) and Hospital Sultanah Aminah (HSA) over a period of four years (2004 to 2007).

Matched MeSH terms: Radiography
Fulltext Large Solitary Pulmonary Cryptococcoma Mimicking Lung Carcinoma in an Immunocompetent Patient

Anandpara KM, Aswani Y, Hira P

Malays J Med Sci, 2018 Feb;25(1):114-118.
PMID: 29599641 DOI: 10.21315/mjms2018.25.1.13

Cryptococcosis is a life-threatening mycosis typically seen in immunocompromised patients. Pulmonary cryptococcosis generally presents as multiple or solitary nodular opacities. Cryptococcal infection presenting as a destructing cavernoma (cryptococcoma) without diffuse infiltration of the lung is an extremely rare presentation, even in immunocompromised patients. This report presents a healthy, HIV negative, immunocompetent patient who presented with a large solitary lung mass provisionally diagnosed as a lung malignancy on radiological imaging that proved to be a large cryptococcoma after biopsy. The patient was treated with liposomal Amphotericin B and fluconazole, and the lesion showed regression on serial imaging. This case report thus highlights an unconventional presentation of pulmonary cryptococcosis in an immunocompetent individual.

Matched MeSH terms: Radiography

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