Displaying publications 281 - 300 of 427 in total

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  1. Fulltext Factors Affecting the Quality of Sleep in Children
    Fadzil A
    Children (Basel), 2021 Feb 09;8(2).
    PMID: 33572155 DOI: 10.3390/children8020122
    Sleep quality is one of the domains of sleep. Having adequate quality sleep is defined as one's "feeling fresh" after waking-up. Inadequate sleep quality results in sleep insufficiency producing a variety of symptoms and signs. The central nervous system is affected the most in children, although other system too may be involved. Several factors affect sleep quality in children including genetics, sleep habits, medical problems, parents/caregiver factors, screen time and the child's environment. These factors are inter-related and dynamic. The outcome of sleep insufficiency is many involving neurocognitive and neurobehavior, mood and emotional issues and specific conditions, like pulmonary hypertension, cor pulmonale and obesity. Management should start with proper history taking to identify the multifaceted nature of the condition. Treatment is planned cognizant of the age of the patient and the associated etiological factors, and should involve both the children and their parents.
    Matched MeSH terms: Central Nervous System
  2. Blood-Brain Barrier Permeability of Asiaticoside, Madecassoside and Asiatic Acid in Porcine Brain Endothelial Cell Model
    Hanapi NA, Mohamad Arshad AS, Abdullah JM, Tengku Muhammad TS, Yusof SR
    J Pharm Sci, 2021 02;110(2):698-706.
    PMID: 32949562 DOI: 10.1016/j.xphs.2020.09.015
    Neurotherapeutic potentials of Centella asiatica and its reputation to boost memory, prevent cognitive deficits and improve brain functions are widely acknowledged. The plant's bioactive compounds, i.e. asiaticoside, madecassoside and asiatic acid were reported to have central nervous system (CNS) actions, particularly in protecting the brain against neurodegenerative disorders. Hence, it is important for these compounds to cross the blood-brain barrier (BBB) to be clinically effective therapeutics. This study aimed to explore the capability of asiaticoside, madecassoside and asiatic acid to cross the BBB using in vitro BBB model from primary porcine brain endothelial cells (PBECs). Our findings showed that asiaticoside, madecassoside and asiatic acid are highly BBB permeable with apparent permeability (Papp) of 70.61 ± 6.60, 53.31 ± 12.55 and 50.94 ± 10.91 × 10-6 cm/s respectively. No evidence of cytotoxicity and tight junction disruption of the PBECs were observed in the presence of these compounds. Asiatic acid showed cytoprotective effect towards the PBECs against oxidative stress. This study reported for the first time that Centella asiatica compounds demonstrated high capability to cross the BBB, comparable to central nervous system drugs, and therefore warrant further development as therapeutics for the treatment of neurodegenerative diseases.
    Matched MeSH terms: Central Nervous System Agents
  3. Fulltext Gliosarcoma of a brain: a challenging diagnosis
    Nornazirah Azizan, Nor Haizura Ab Rani, Ahmad Toha Samsudin, Fadhli Mustaffa, Firdaus Hayati
    Borneo Journal of Medical Sciences, 2020;14(3):39-44.
    MyJurnal
    Gliosarcoma is a rare primary malignant tumour of the central nervous system. A 28-year-old radiographer without a history of neurological disorder, malignancy or trauma presented with unprovoked seizures. He was symptom-free for 3 years but developed relapsed. Computed tomography of the brain was consistent with anaplastic convexity meningioma which was identical via intraoperative findings. However, the final histology revealed gliosarcoma of the brain. He recovered well postoperatively without any neurological deficit and had completed adjuvant chemo-radiotherapy. He was asymptomatic during follow up with no tumour recurrence. Gliosarcoma with predominant sarcomatous component mimicking a meningioma has prolonged survival as compared to a case with predominant glioblastoma component. Hence, the discordance between clinical, radiological, intraoperative and histopathological findings is a challenge in establishing a diagnosis of gliosarcoma.
    Matched MeSH terms: Central Nervous System
  4. Guillain-Barré syndrome
    Shahrizaila N, Lehmann HC, Kuwabara S
    Lancet, 2021 03 27;397(10280):1214-1228.
    PMID: 33647239 DOI: 10.1016/S0140-6736(21)00517-1
    Guillain-Barré syndrome is the most common cause of acute flaccid paralysis worldwide. Most patients present with an antecedent illness, most commonly upper respiratory tract infection, before the onset of progressive motor weakness. Several microorganisms have been associated with Guillain-Barré syndrome, most notably Campylobacter jejuni, Zika virus, and in 2020, the severe acute respiratory syndrome coronavirus 2. In C jejuni-related Guillain-Barré syndrome, there is good evidence to support an autoantibody-mediated immune process that is triggered by molecular mimicry between structural components of peripheral nerves and the microorganism. Making a diagnosis of so-called classical Guillain-Barré syndrome is straightforward; however, the existing diagnostic criteria have limitations and can result in some variants of the syndrome being missed. Most patients with Guillain-Barré syndrome do well with immunotherapy, but a substantial proportion are left with disability, and death can occur. Results from the International Guillain-Barré Syndrome Outcome Study suggest that geographical variations exist in Guillain-Barré syndrome, including insufficient access to immunotherapy in low-income countries. There is a need to provide improved access to treatment for all patients with Guillain-Barré syndrome, and to develop effective disease-modifying therapies that can limit the extent of nerve injury. Clinical trials are currently underway to investigate some of the potential therapeutic candidates, including complement inhibitors, which, together with emerging data from large international collaborative studies on the syndrome, will contribute substantially to understanding the many facets of this disease.
    Matched MeSH terms: Peripheral Nervous System Diseases
  5. A Rare Case of an Infant with Left Hemiparesis: A Case Report of Bilateral Open-lip Schizencephaly
    Siti BC, Zulkifli MM, Mohd Yusoff SS, Muhamad R, Ahmad TM
    Malays Fam Physician, 2020;15(3):90-94.
    PMID: 33329869
    Schizencephaly is a very rare congenital birth defect. It is characterized by a cortical brain malformation that manifests as a grey-matter-lined cleft extending from the ependyma to the pia mater. It is a rare condition, and few cases have been reported in the literature. The exact cause is unknown. Herein, we report a case of an infant presenting with left side hemiparesis. The CT scan of her brain revealed right fronto-temporal and left parieto-temporal open-lip schizencephaly; thus, urgent referral to a pediatric neurologist was made for early intervention.
    Matched MeSH terms: Nervous System Malformations
  6. Fulltext Spontaneous spinal subarachnoid haemorrhage: a rare complication of dengue fever
    Nur Hidayati Mohd Sharif, Nor Arisah Misnan, Norashikin Saidon, Phaik Yee Ooi, Hilwati Hashim
    Journal of Clinical and Health Sciences, 2017;2:54-57.
    A 37-year-old woman presented with a short history of fever and bilateral lower limb
    weakness. She also had impaired sensory function up to T4 spine level and lax anal tone.
    Laboratory investigations confirmed dengue infection with mild thrombocytopenia. MRI of the
    spine showed a spinal subarachnoid haemorrhage from the level of T4 till T9. Despite
    medical and surgical interventions, her lower limb weakness persists. A high index of
    suspicion is needed to recognise dengue-related neurological complications. This diagnosis
    should be considered in any patients from dengue endemic areas presenting with acute
    febrile illness with atypical neurological manifestations.
    Matched MeSH terms: Nervous System Diseases
  7. Experimental Nipah virus infection in pigs and cats
    Middleton DJ, Westbury HA, Morrissy CJ, van der Heide BM, Russell GM, Braun MA, et al.
    J Comp Pathol, 2002 Feb-Apr;126(2-3):124-36.
    PMID: 11945001 DOI: 10.1053/jcpa.2001.0532
    A human isolate of Nipah virus from an outbreak of febrile encephalitis in Malaysia that coincided with a field outbreak of disease in pigs was used to infect eight 6-week-old pigs orally or subcutaneously and two cats oronasally. In pigs, the virus induced a respiratory and neurological syndrome consistent with that observed in the Malaysian pigs. Not all the pigs showed clinical signs, but Nipah virus was recovered from the nose and oropharynx of both clinically and sub-clinically infected animals. Natural infection of in-contact pigs, which was readily demonstrated, appeared to be acute and self-limiting. Subclinical infections occurred in both inoculated and in-contact pigs. Respiratory and neurological disease was also produced in the cats, with recovery of virus from urine as well as from the oropharynx. The clinical and pathological syndrome induced by Nipah virus in cats was comparable with that associated with Hendra virus infection in this species, except that in fatal infection with Nipah virus there was extensive inflammation of the respiratory epithelium, associated with the presence of viral antigen. Viral shedding via the nasopharynx, as observed in pigs and cats in the present study, was not a regular feature of earlier reports of experimental Hendra virus infection in cats and horses. The findings indicate the possibility of field transmission of Nipah virus between pigs via respiratory and oropharyngeal secretions.
    Matched MeSH terms: Nervous System Diseases/pathology; Nervous System Diseases/veterinary; Nervous System Diseases/virology
  8. Fulltext Hormones in experimental autoimmune encephalomyelitis (EAE) animal models
    Ghareghani M, Ghanbari A, Eid A, Shaito A, Mohamed W, Mondello S, et al.
    Transl Neurosci, 2021 Jan 01;12(1):164-189.
    PMID: 34046214 DOI: 10.1515/tnsci-2020-0169
    Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) in which activated immune cells attack the CNS and cause inflammation and demyelination. While the etiology of MS is still largely unknown, the interaction between hormones and the immune system plays a role in disease progression, but the mechanisms by which this occurs are incompletely understood. Several in vitro and in vivo experimental, but also clinical studies, have addressed the possible role of the endocrine system in susceptibility and severity of autoimmune diseases. Although there are several demyelinating models, experimental autoimmune encephalomyelitis (EAE) is the oldest and most commonly used model for MS in laboratory animals which enables researchers to translate their findings from EAE into human. Evidences imply that there is great heterogeneity in the susceptibility to the induction, the method of induction, and the response to various immunological or pharmacological interventions, which led to conflicting results on the role of specific hormones in the EAE model. In this review, we address the role of endocrine system in EAE model to provide a comprehensive view and a better understanding of the interactions between the endocrine and the immune systems in various models of EAE, to open up a ground for further detailed studies in this field by considering and comparing the results and models used in previous studies.
    Matched MeSH terms: Central Nervous System
  9. Fulltext Surgical remotion of a cysticercotic granuloma responsible for refractory seizures: A case report
    Hasan MS, Basri HB, Hin LP, Stanslas J
    Surg Neurol Int, 2011;2:177.
    PMID: 22276232 DOI: 10.4103/2152-7806.90698
    BACKGROUND: Neurocysticercosis is the most common parasitic infestation of the central nervous system and an important cause of acquired epilepsy. Although endemic in developing countries, with an increased immigration from the endemic regions, it is also seen progressively in other parts of the world. Hence, there is an increased need for awareness of neurocysticercosis in the non-endemic areas.

    CASE DESCRIPTION: The case described here is of a 13-year-old girl who presented with refractory seizures. She had been on antiepileptic medication and had also received anti-parasitic treatment for neurocysticercosis. Surgical intervention was recommended because the seizures were resistant to treatment and also because the diagnosis could not be clearly established. Following surgery, the seizures have been under control and the patient has been doing well.

    CONCLUSION: Neurocysticercosis can be a potential cause of refractory seizure even in non-endemic countries. Some cases may be difficult to diagnose. Clinical presentation of seizure and brain imaging should be given priority over blood investigations for diagnosing neurocysticercosis and advanced neurosurgical intervention can be considered in suitable cases for better outcome.

    Matched MeSH terms: Central Nervous System
  10. Fulltext Effects of a Herbal Ergogenic Drink on Cycling Performance in Young Cyclists
    Malays J Nutr, 2001;7(1):-.
    MyJurnal
    It is essential to replace fluids lost so as to remain well hydrated during exercise. The intake of fluids is considered a physiological ergogenic aid to enhance exercise performance. There are currently several products in the market that are believed to have ergogenic properties which act as fluid replacement drinks during exercise. One such drink available in the Malaysian market is ‘AgroMas®’ herbal drink whose efficacy is yet to be proven. The purpose of this study was, therefore, to evaluate the effects of acute ingestion of this herbal drink (H) or a coloured water placebo (P) on cycling performance. Nine healthy and trained young male cyclists (age: 16.2 ± 0.5 years) exercised on a cycle ergometer at 71.9 ± 0.7% of maximal oxygen consumption (VO2max) until exhaustion on two occasions at 1-week intervals. During each exercise bout, subjects received 3ml kg-1 body weight of H or P every 20 min in a double-blind randomised study design. There was no significant difference between H and P trials in the total work time to exhaustion (83.7 ± 4.6 and 81.5 ± 5.0 min respectively). Changes in oxygen consumption, heart rate and perceived rate of exertion were similar for both types of drinks. These results demonstrate that the herbal drink and the placebo elicited similar physiological responses and exercise performance during endurance cycling. It is therefore concluded that AgroMas® herbal drink and water ingestion resulted in a similar ergogenic response on cycling performance in young cyclists.
    Matched MeSH terms: Central Nervous System Stimulants
  11. Fulltext Primary large B cell lymphoma of the parotid gland: case report
    Almothafar, B., Wong, L., Noorafidah, M.D.
    JUMMEC, 2011;14(1):26-30.
    MyJurnal
    Primary parotid lymphoma is uncommon and rarely suspected. In most cases, the disease would have disseminated at the time of diagnosis. We describe a case of primary non-Hodgkin’s lymphoma of the parotid gland which progressed to the central nervous system. Clinical history is of limited value in identifying this condition. Diagnostic imaging studies (CT or MRI) may indicate whether or not the mass is salivary in origin but do not help to confirm the diagnosis. In this case, it was deemed that FNA alone is incapable of determining the precise histological subtype for lymphoma, whilst a tru-cut biopsy demonstrated a more sensitive method of determining the diagnosis. The lessons learned from this case would prove useful for other health care providers to make an early diagnosis and hopefully manage more effectively if similar conditions appear in their practice. Performing the appropriate measures can help to not only improve the prognosis but may even avert the prospect of unnecessary surgery.
    Matched MeSH terms: Nervous System
  12. Fulltext Issues And challenges in the management Of methamphetamine dependence in pregnancy
    Farid Yusof, Suzaily Wahab
    Malaysian Journal of Medicine and Health Sciences, 2015;11(1):89-92.
    MyJurnal
    Data from the Malaysian National Drugs Agency December 2013 Report, showed that among 7864 drug users, 632 were abusing Amphetamine Type Stimulant. Rates of admission due to Methamphetamine abuse in pregnancy are higher compared with men and non- pregnant lady in the United States.1 A number of issues may complicate the management of pregnant women who abused methamphetamine such as the low motivation for them to come forward voluntarily for treatment, the high rates of fetal and maternal complications due to methamphetamine abuse,2,3 and the inavailabiliy of effective treatment for methamphetamine dependence.
    Matched MeSH terms: Central Nervous System Stimulants
  13. Fulltext Depression In Parkinson Disease: Clinical Features And Aetiology
    Chan, Y.F., Zainal, N.Z.
    Malaysian Journal of Psychiatry, 2010;19(1):1-11.
    MyJurnal
    Parkinson Disease (PD) is a neurodegenerative disorder of the central nervous system that often impairs the patient’s motor skills, speech and other functions. The four cardinal signs of parkinsonism are resting tremor, bradykinesia, cogwheel rigidity and postural instability. The prevalence of depression in PD ranges from 4% to 75%. However depression in PD is often mistakenly as the presentation of the disease itself. Therefore this paper reviewed the clinical feature of depression in PD and explored the aetiology of depression in PD.
    Matched MeSH terms: Central Nervous System
  14. Fulltext The detrimental effects of lead on human and animal health
    Assi MA, Hezmee MN, Haron AW, Sabri MY, Rajion MA
    Vet World, 2016 Jun;9(6):660-71.
    PMID: 27397992 DOI: 10.14202/vetworld.2016.660-671
    Lead, a chemical element in the carbon group with symbol Pb (from Latin: Plumbum, meaning "the liquid silver") and has an atomic number 82 in the periodic table. It was the first element that was characterized by its kind of toxicity. In animal systems, lead (Pb) has been incriminated in a wide spectrum of toxic effects and it is considered one of the persistent ubiquitous heavy metals. Being exposed to this metal could lead to the change of testicular functions in human beings as well as in the wildlife. The lead poising is a real threat to the public health, especially in the developing countries. Accordingly, great efforts on the part of the occupational and public health have been taken to curb the dangers of this metal. Hematopoietic, renal, reproductive, and central nervous system are among the parts of the human body and systems that are vulnerable toward the dangers following exposure to high level of Pb. In this review, we discussed the massive harmful impact that leads acetate toxicity has on the animals and the worrying fact that this harmful toxicant can be found quite easily in the environment and abundance. Highlighting its (Pb) effects on various organs in the biological systems, its economic, as well as scientific importance, with the view to educate the public/professionals who work in this area. In this study, we focus on the current studies and research related to lead toxicity in animals and also to a certain extent toward human as well.
    Matched MeSH terms: Nervous System
  15. Fulltext Niigata Minamata disease: a revisit
    Hasni MJ
    Malaysian Journal of Public Health Medicine, 2014;14(1):47-54.
    MyJurnal
    Minamata disease is a well-known mercury contamination that happened in Japan in 1953. Due to demand during world war, second mercury disaster occurred in Niigata Prefecture in 1965. This is a review on the Niigata Minamata disease based on available documents and local expert opinions on the disaster. The aims of this paper are to record exposure history like the source of mercury in Agano River and specific fish that was associated with the disease. It is for an appraisal of the basic mercury exposure control, particularly to protect Japanese and world population during that time. There was indication that initial exposure limit for mercury was calculated incorrectly, and higher safe dose was applied. This epidemiological study is very useful and significant in comprehend the correct estimation of the human exposure to any hazardous substances.
    Matched MeSH terms: Mercury Poisoning, Nervous System
  16. Fulltext The stress inducing factors among preclinical students in a public university in Selangor
    Adlina, S., Narimah, A.H.H., Hakimi, Z.A., Suthahar, A., M Nor Hisyam, R., Ruhaida, M.K., et al.
    Malaysian Journal of Public Health Medicine, 2007;7(1):56-59.
    MyJurnal
    Stress has been recognized one of the factors causing disease. About 70-80% of all diseases may be stress related. Thus, stress management can be a part of an early measure of disease prevention. A descriptive cross sectional, randomized study was conducted to determine the stress inducing factors among preclinical students (universal sampling) in a public university in Selangor, Malaysia from 24th April to May 2005. A total of 163 students (52.8% year 1, 36.8% year 2 and 10.4% year 3) were interviewed in the data collection process. The main reasons students entered - medical school was because of their own interest or ambition (65%) and family influence (20.9%). Majority (76.4%) suffered moderate to great stress over hot conditions in lecture hall, tutoriaV small group session rooms and laboratories while 53.4% suffered when using the other facilities like cafeteria, toilet and transportation:. Almost all (95.1%) felt that examination was the most stressful, followed by early clinical exposure sessions (68.1%), problem·based learning sessions (62.5%), hospital visitations (59.7%), tutoriay small group sessions (49.3%), practical class (44.5%) and attending lectures (3 8.5%). Musculoskeletal System was the most stressful module among the first year students, followed by Nervous System and Gastrointestinal System with the percentage of 94.2%, 90.7% and 88.4% respectively while, 95% of the second year students felt that General, Hemopoietic ci? Lymphoid and Nervous System are the most stressful modules. This study revealed that academic sessions and lack of conducive teaching and learning environment as the main stress inducing contributors to preclinical medical students.
    Matched MeSH terms: Nervous System
  17. Consent for lumbar puncture -factors that influence the decision
    Malik, A.S.
    Malaysian Journal of Paediatrics and Child Health, 2000;12(1):35-41.
    MyJurnal
    Lumbar puncture (LP) is an important procedure both for diagnostic and therapeutic purposes. In Kelantan, Malaysia, on many occasions consent for this procedure is not granted by patients or guardians. The aim of this study was to find out the factors that influence the decision to grant or refuse the consent for LP. This was a cross-sectional study in which 86 parents (who agreed or refused to give consent for LP on their child) were interviewed by using a standard questionnaire. A scoring system was used to assess their knowledge about the purpose and technique of the procedure. Consent for LP was granted in 23 and refused in 27 children. The refusal rate was significantly higher when family members other than parents made the decision. The factors which did not play a statistically significant role in decision-making included: age of the child and parents; gender of the patient; number of children in the family; patient's birth order among the siblings; place of residence; monthly income of the family; parents' level of education; and number of days after admission when LP was requested. The factors that positively influenced the decision to give consent included knowledge about the purpose of LP and underlying disease. In order to receive positive consent for LP it is concluded that the parents/guardians and other family members who may influence the decision-making should be explained the role of LP in (1) making diagnosis and (2) choosing right antibiotics for treatment. They should also be informed about the side-effects of antibiotics, which may be used unnecessarily in unconfirmed cases of central nervous system infections.
    Matched MeSH terms: Central Nervous System Infections
  18. Fulltext Survivability of Acanthamoeba strains isolated from clinical and environmental specimens during axenization
    Nurul Farhana Jufri, Anisah Nordin, Mohamed Kamel Abd Ghani, Yusof Suboh, Noraina Abd Rahim
    Jurnal Sains Kesihatan Malaysia, 2011;9(1):1-3.
    MyJurnal
    Acanthamoeba is a free living protozoa that can cause keratitis and granulomatous amoebic encephalitis. Physiological characteristics of this amoeba are found to have a medical importance in which it can be related to the pathogenicity potential of the organism. This study was carried out to investigate the physiological characteristics of survivability during axenization. Six Acanthamoeba strains from three clinical isolates (HSB 1, HKL 48 and HKL 95) and three environmental isolates (PHS 2, PHS 11 and PHS 15) were used in this study. Axenization test was done by treating cysts with hydrochloric acid (3%) and Page saline containing Gentamicin (100 µg/ml). Cysts were then cultured into PYG enrich media, incubated at 30oC and the presence and proliferation of trophozoites of Acanthamoeba were observed. This study showed that PHS 15, HSB 1, HKL 48 and HKL 95 could be axenized but they have poor proliferation rate in PYG enrich media. The result showed that the difference between both clinical and environmental isolates was observed in two strains; PHS 2 and PHS 11. This indicates that there is a possibility that the physiological traits of strains from both isolates are the same and strains from the environment are able to show the pathogenic potential and capable of causing infection to human.
    Matched MeSH terms: Central Nervous System Parasitic Infections
  19. Fulltext Spontaneous spinal subarachnoid haemorrhage: a rare complication of dengue fever
    Nur Hidayati Mohd Sharif, Nor Arisah Misnan, Norashikin Saidon, Phaik Yee Ooi, Hilwati Hashim
    Journal of Clinical and Health Sciences, 2017;2(2):54-57.
    MyJurnal
    A 37-year-old woman presented with a short history of fever and bilateral lower limb
    weakness. She also had impaired sensory function up to T4 spine level and lax anal tone.
    Laboratory investigations confirmed dengue infection with mild thrombocytopenia. MRI of the
    spine showed a spinal subarachnoid haemorrhage from the level of T4 till T9. Despite
    medical and surgical interventions, her lower limb weakness persists. A high index of
    suspicion is needed to recognise dengue-related neurological complications. This diagnosis
    should be considered in any patients from dengue endemic areas presenting with acute
    febrile illness with atypical neurological manifestations.
    Matched MeSH terms: Nervous System Diseases
  20. Fulltext Cytomegalovirus infection associated with Atypical Bronchopulmonary Dysplasia in a Preterm Neonate: a case report
    Aisha Fadhilah Abang Abdullah, Zurina Zainudin, Dg. Zuraini Sahadan
    Malaysian Journal of Medicine and Health Sciences, 2018;14(2):97-99.
    MyJurnal
    Cytomegalovirus (CMV) is frequently isolated from neonates. Symptomatic infection is only apparent in 10% of affected babies with particular predilection for the reticuloendothelial and central nervous system. Isolated respiratory system involvement is rarely encountered. We report a case of a premature 32 weeks infant who required prolonged oxygen dependency and treated for bronchopulmonary dysplasia. The diagnosis of CMV pneumonitis was only discovered after detection of CMV DNA in the bronchoalveolar lavage. A high level of clinical awareness is crucial as a definite diagnosis and treatment will significantly alter the morbidity and the cost of therapy.
    Matched MeSH terms: Nervous System
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