OBJECTIVE: Analyze indications and type of prenatal diagnostic procedures performed.
METHOD: This retrospective audit was conducted at a dedicated fetal medicine center in Petaling Jaya. All invasive prenatal diagnosis procedures performed from 2003 up until 2010 (amniocentesis, chorionic villous sampling and fetal blood sampling) were analyzed.
RESULT: A total of 1560 invasive prenatal diagnostic procedures were performed during the 8 year period. Advanced maternal age is the leading indication for invasive prenatal diagnostic procedures followed by fetal abnormalities. The fetal loss rate was 0.2% for amniocentesis and 1.2% for CVS.
CONCLUSION: Advanced maternal age is the leading indication for invasive prenatal diagnostic procedures at this centre but is on a declining trend. The fetal loss rates are comparable to auditable standards set by professional bodies, in this case, the Royal College of Obstetricians & Gynecologists of London.
Morphological processing in visual word recognition has been extensively studied in a few languages, but other languages with interesting morphological systems have received little attention. Here, we examined Malay, an Austronesian language that is agglutinative. Agglutinative languages typically have a large number of morphemes per word. Our primary aim was to facilitate research on morphological processing in Malay by augmenting the Malay Lexicon Project (a database containing lexical information for almost 10,000 words) to include a breakdown of the words into morphemes as well as morphological properties for those morphemes. A secondary goal was to determine which morphological variables influence Malay word recognition. We collected lexical decision data for Malay words that had one prefix and one suffix, and first examined the predictive power of 15 morphological and four lexical variables on response times (RT). Of these variables, two lexical and three morphological variables emerged as strong predictors of RT. In GAMM models, we found a facilitatory effect of root family size, and inhibitory effects of prefix length and prefix percentage of more frequent words (PFMF) on RT. Next, we explored the interactions between overall word frequency and several of these predictors. Of particular interest, there was a significant word frequency by root family size interaction in which the effect of root family size is stronger for low-frequency words. We hope that this initial work on morphological processing in Malay inspires further research in this and other understudied languages, with the goal of developing a universal theory of morphological processing.