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Cardiac biomarkers in chronic kidney disease are independently associated with myocardial edema and diffuse fibrosis by cardiovascular magnetic resonance

Arcari L 1 , Engel J 2 , Freiwald T 2 , Zhou H 1 , Zainal H 1 , Gawor M 3 Show all authors , Buettner S 2 , Geiger H 2 , Hauser I 2 , Nagel E 1 , Puntmann VO 4

Affiliations 

  • 1 Institute of Experimental and Translational Cardiovascular Imaging, DZHK Centre for Cardiovascular Imaging, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany
  • 2 Department of Nephrology, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany
  • 3 Department of Cardiology, University Hospital Warsaw, Warsaw, Poland
  • 4 Institute of Experimental and Translational Cardiovascular Imaging, DZHK Centre for Cardiovascular Imaging, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany. [email protected]
J Cardiovasc Magn Reson, 2021 06 07;23(1):71.
PMID: 34092229 DOI: 10.1186/s12968-021-00762-z

Abstract

BACKGROUND: High sensitivity cardiac troponin T (hs-cTnT) and NT-pro-brain natriuretic peptide (NT-pro BNP) are often elevated in chronic kidney disease (CKD) and associated with both cardiovascular remodeling and outcome. Relationship between these biomarkers and quantitative imaging measures of myocardial fibrosis and edema by T1 and T2 mapping remains unknown.

METHODS: Consecutive patients with established CKD and estimated glomerular filtration rate (eGFR) 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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