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Limited utility of plasma M30 in discriminating non-alcoholic steatohepatitis from steatosis--a comparison with routine biochemical markers

Chan WK 1 , Sthaneshwar P 2 , Nik Mustapha NR 3 , Mahadeva S 1

Affiliations 

  • 1 Gastroenterology and Hepatology Unit, Gastrointestinal Endoscopy Unit, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 2 Division of Laboratory Medicine, Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 3 Department of Pathology, Hospital Alor Setar, Alor Setar, Kedah, Malaysia
PLoS One, 2014;9(9):e105903.
PMID: 25184298 DOI: 10.1371/journal.pone.0105903

Abstract

The utility of Cytokeratin-18 fragment, namely CK18Asp396 (M30), for the diagnosis of non-alcoholic steatohepatitis (NASH) is currently uncertain. We aimed to provide further data in this area among multi-ethnic Asian subjects with NAFLD.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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