Friendship is a topic that should be emphasized and studied, and it can be positive or negative. There are many forms of friendship that can be termed, but it may also differ from one's perspective and certain characteristics of a person. The value of friendship is very important to study in order to know the level of our friendships. In college student development, peer influence can also influence student engagement in engaging in their college activities. It can be seen in terms of involvement in sports activities, curriculum activities and more. The main purpose of this study was to develop of Friendship instrument in chemistry and engagement of SQS UUM students and find the relationships between genders with chemistry and engagement. Using Factor Analysis in order to develop valid and reliable of the friendship Instrument based on chemistry and engagement. In order to study the validity of the data, face validity was used before the instrument was distributed in which the pilot study was conducted. To determine which factor is best, the analysis uses varimax rotation and selects which component is best and meets the criteria. Normality test was used to find the data was normal or nonnormal. Spearman Correlation and Chi Square Test method used in the non-normal data to find the relationship of selected variables.