Oral peptide delivery: challenges and the way ahead

Dubey SK 1 , Parab S 2 , Dabholkar N 2 , Agrawal M 3 , Singhvi G 2 , Alexander A 4 Show all authors , Bapat RA 5 , Kesharwani P 6

Affiliations 

  • 1 Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Pilani Campus, Rajasthan 333031, India; Emami Ltd, Anandapur, Kolkata - 700107. Electronic address: [email protected]
  • 2 Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Pilani Campus, Rajasthan 333031, India
  • 3 Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai, Chhattisgarh 490024, India
  • 4 National Institute of Pharmaceutical Education and Research (NIPER-Guwahati), Department of Pharmaceuticals, Ministry of Chemicals & Fertilizers, Government of India, Sila Katamur (Halugurisuk), Changsari, Kamrup 781101, India
  • 5 Division of Clinical Dentistry, School of Dentistry, International Medical University Kuala Lumpur/12 6, Jalan Jalil Perkasa 19, Bukit Jalil, 57000 Bukit Jalil, Wilayah Persekutuan, Kuala Lumpur, Malaysia
  • 6 Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India. Electronic address: [email protected]
Drug Discov Today, 2021 04;26(4):931-950.
PMID: 33444788 DOI: 10.1016/j.drudis.2021.01.001

Abstract

Peptides and proteins have emerged as potential therapeutic agents and, in the search for the best treatment regimen, the oral route has been extensively evaluated because of its non-invasive and safe nature. The physicochemical properties of peptides and proteins along with the hurdles in the gastrointestinal tract (GIT), such as degrading enzymes and permeation barriers, are challenges to their delivery. To address these challenges, several conventional and novel approaches, such as nanocarriers, site-specific and stimuli specific delivery, are being used. In this review, we discuss the challenges to the oral delivery of peptides and the approaches used to tackle these challenges.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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