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Pretreatment of Blumea lacera leaves ameliorate acute ulcer and oxidative stress in ethanol-induced Long-Evan rat: A combined experimental and chemico-biological interaction

Hossen MA 1 , Reza ASMA 2 , Ahmed AMA 3 , Islam MK 1 , Jahan I 1 , Hossain R 1 Show all authors , Khan MF 1 , Maruf MRA 1 , Haque MA 4 , Rahman MA 5

Affiliations 

  • 1 Department of Pharmacy, International Islamic University Chittagong, Chittagong, 4318, Bangladesh
  • 2 Department of Pharmacy, International Islamic University Chittagong, Chittagong, 4318, Bangladesh; Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong, 4331, Bangladesh
  • 3 Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong, 4331, Bangladesh; Department of Genetic Engineering and Biotechnology, University of Chittagong, Chittagong, 4331, Bangladesh
  • 4 Department of Pharmacy, International Islamic University Chittagong, Chittagong, 4318, Bangladesh; Drug & Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, 50300, Kuala Lumpur, Malaysia
  • 5 Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong, 4331, Bangladesh. Electronic address: [email protected]
Biomed Pharmacother, 2021 Mar;135:111211.
PMID: 33421733 DOI: 10.1016/j.biopha.2020.111211

Abstract

Blumea lacera (Burm.f.) DC. is described as a valuable medicinal plant in various popular systems of medicine. The aim of the experiment reports the in vivo antiulcer activity of methanol extract of Blumea lacera (MEBLL) and in silico studies of bioactive constituents of MEBLL. In this study, fasted Long-Evans rat treated with 80 % ethanol (0.5 mL) to induce gastric ulcer, were pretreated orally with MEBLL at different doses (250 and 500 mg/kg, p.o., b.w) and omeprazole (20 mg/kg, p.o.) and distilled water were used as a reference drug and normal control respectively. In silico activity against gastric H+-K+ATPase enzyme was also studied. The findings demonstrated that the treatment with MEBLL attenuated markedly ulcer and protected the integrity of the gastric mucosa by preventing the mucosal ulceration altered biochemical parameters of gastric juice such total carbohydrate, total protein and pepsin activity. Additionally, the experimental groups significantly (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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