A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

Shen X; Howard DM; Adams MJ; Hill WD; Clarke TK; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; Deary IJ; Whalley HC; McIntosh AM

doi:10.1038/s41467-020-16022-0

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A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

Shen X ¹ , Howard DM ¹ , Adams MJ ¹ , Hill WD ² , Clarke TK ¹ , Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium Show all authors , Deary IJ ² , Whalley HC ¹ , McIntosh AM ³

Affiliations

¹ Division of Psychiatry, University of Edinburgh, Edinburgh, UK
² Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
³ Division of Psychiatry, University of Edinburgh, Edinburgh, UK. [email protected]

Nat Commun, 2020 05 08;11(1):2301.

PMID: 32385265 DOI: 10.1038/s41467-020-16022-0

Abstract

Depression is a leading cause of worldwide disability but there remains considerable uncertainty regarding its neural and behavioural associations. Here, using non-overlapping Psychiatric Genomics Consortium (PGC) datasets as a reference, we estimate polygenic risk scores for depression (depression-PRS) in a discovery (N = 10,674) and replication (N = 11,214) imaging sample from UK Biobank. We report 77 traits that are significantly associated with depression-PRS, in both discovery and replication analyses. Mendelian Randomisation analysis supports a potential causal effect of liability to depression on brain white matter microstructure (β: 0.125 to 0.868, pFDR

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.