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Predictors of advanced fibrosis in elderly patients with biopsy-confirmed nonalcoholic fatty liver disease: the GOASIA study

Pitisuttithum P 1 , Chan WK 2 , Piyachaturawat P 1 , Imajo K 3 , Nakajima A 3 , Seki Y 4 Show all authors , Kasama K 4 , Kakizaki S 5 , Fan JG 6 , Song MJ 7 , Yoon SK 7 , Dan YY 8 , Lesmana L 9 , Ho KY 8 , Goh KL 2 , Wong VWS 10 , Treeprasertsuk S 11

Affiliations 

  • 1 Department of Medicine, Chulalongkorn University, Bangkok, Thailand
  • 2 Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 3 Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
  • 4 Weight Loss and Metabolic Surgery Centre, Yotsuya Medical Cube, Tokyo, Japan
  • 5 Department of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, Gunma, Japan
  • 6 Department of Gastroenterology, Shanghai Jiaotong University School of Medicine, Shanghai, China
  • 7 Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea
  • 8 Department of Medicine, National University of Singapore, Singapore, Singapore
  • 9 Digestive Disease and Oncology GI Centre, Medistra Hospital, Jakarta, Indonesia
  • 10 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
  • 11 Department of Medicine, Chulalongkorn University, Bangkok, Thailand. [email protected]
BMC Gastroenterol, 2020 Apr 06;20(1):88.
PMID: 32252638 DOI: 10.1186/s12876-020-01240-z

Abstract

BACKGROUND: The Gut and Obesity in Asia (GOASIA) Workgroup was formed to study obesity and gastrointestinal diseases in the Asia Pacific region. We aimed to 1) compare the characteristics of elderly (i.e. age ≥ 60) vs. non-elderly patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD); 2) identify predictors of advanced fibrosis in elderly patients with NAFLD; and 3) assess the performance of non-invasive fibrosis scores in the prediction of advance fibrosis in the elderly population.

METHODS: We abstracted the data of 1008 patients with NAFLD from nine centers across eight countries. Characteristics of elderly and non-elderly patients with NAFLD were compared using 1:3 sex-matched analysis.

RESULTS: Of the 1008 patients, 175 were elderly [age 64 (62-67) years], who were matched with 525 non-elderly patients [46 (36-54) years]. Elderly patients were more likely to have advanced fibrosis (35.4% vs. 13.3%; p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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