Multiple crystallization as a potential strategy for efficient recovery of succinic acid following fermentation with immobilized cells

Luthfi AAI 1 , Tan JP 1 , Isa NFAM 2 , Bukhari NA 1 , Shah SSM 1 , Mahmod SS 1 Show all authors , Jahim JM 3

Affiliations 

  • 1 Research Centre for Sustainable Process Technology (CESPRO), Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia (UKM), 43600, Bangi, Selangor, Malaysia
  • 2 Department of Chemical and Process Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia (UKM), 43600, Bangi, Selangor, Malaysia
  • 3 Research Centre for Sustainable Process Technology (CESPRO), Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia (UKM), 43600, Bangi, Selangor, Malaysia. [email protected]
Bioprocess Biosyst Eng, 2020 Jul;43(7):1153-1169.
PMID: 32095989 DOI: 10.1007/s00449-020-02311-x

Abstract

This study aimed to enhance the crystallizability of bio-based succinic acid for its efficient recovery while maintaining the end product at the highest purity. Immobilization of Actinobacillus succinogenes was initially evaluated based on three different carriers: volcanic glass, clay pebbles, and silica particles. The adsorption capacity of metabolites with a low concentration (10 g/L) and a high concentration (40 g/L) was investigated. It was demonstrated that clay pebbles adsorbed the least succinic acid (

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