Macroline-Sarpagine Bisindole Alkaloids with Antiproliferative Activity from Alstonia penangiana

Yeap JS 1 , Saad HM 2 , Tan CH 2 , Sim KS 2 , Lim SH 1 , Low YY 1 Show all authors , Kam TS 1

Affiliations 

  • 1 Department of Chemistry, Faculty of Science , University of Malaya , 50603 Kuala Lumpur , Malaysia
  • 2 Institute of Biological Sciences, Faculty of Science , University of Malaya , 50603 Kuala Lumpur , Malaysia
J Nat Prod, 2019 11 22;82(11):3121-3132.
PMID: 31642315 DOI: 10.1021/acs.jnatprod.9b00712

Abstract

A methanol extract of the stem bark of the Malayan Alstonia penangiana provided seven new bisindole alkaloids, comprising six macroline-sarpagine alkaloids (angustilongines E-K, 1-6) and one macroline-pleiocarpamine bisindole alkaloid (angustilongine L, 7). Analysis of the spectroscopic data (NMR and MS) of these compounds led to the proposed structures of these alkaloids. The macroline-sarpagine alkaloids (1-6) showed in vitro growth inhibitory activity against a panel of human cancer cell lines, inclusive of KB, vincristine-resistant KB, PC-3, LNCaP, MCF7, MDA-MB-231, HT-29, HCT 116, and A549 cells (IC50 values: 0.02-9.0 μM).

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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