Regenerative Endodontic Procedures in Necrotic Mature Teeth with Periapical Radiolucencies: A Preliminary Randomized Clinical Study

Arslan H 1 , Ahmed HMA 2 , Şahin Y 3 , Doğanay Yıldız E 4 , Gündoğdu EC 5 , Güven Y 6 Show all authors , Khalilov R 5

Affiliations 

  • 1 Department of Endodontics, Faculty of Dentistry, Health Sciences University, İstanbul, Turkey. Electronic address: [email protected]
  • 2 Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia
  • 3 Department of Medical Genetics, Biruni University, Istanbul, Turkey
  • 4 Department of Endodontics, Faculty of Dentistry, Kırıkkale University, Kırıkkale, Turkey
  • 5 Department of Endodontics, Faculty of Dentistry, Ataturk University, Erzurum, Turkey
  • 6 Department of Endodontics, Faculty of Dentistry, Afyon Kocatepe University, Afyon, Turkey
J Endod, 2019 Jul;45(7):863-872.
PMID: 31155298 DOI: 10.1016/j.joen.2019.04.005

Abstract

INTRODUCTION: This preliminary study compared clinical and radiographic outcomes of regenerative endodontic procedures (REPs) with that of conventional root canal treatment (CRCT) in necrotic mature teeth with periapical radiolucencies.

METHODS: Fifty-six mature necrotic teeth with large periapical radiolucencies were distributed into 2 groups: group 1, REPs and group 2, CRCT (n = 28/group). Clinical and radiographic follow-up assessments were undertaken up to 12 months. Statistical analysis was performed using the independent samples t test and the chi-square test, and the level of significance was set at P = .05.

RESULTS: With a follow-up rate of about 73.4% of the total patients for 12 months, favorable clinical and radiographic outcomes were found in 92.3% and 80% in REPs and CRCT groups, respectively, and the difference was not statistically significant (P > .05). Half of the teeth treated with REPs responded to the electric pulp test.

CONCLUSIONS: Regenerative endodontic procedures have the potential to be used as a treatment option for mature teeth with large periapical radiolucencies.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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