The purpose of this research is to investigate the relationship between self-esteem and life satisfaction among adolescents. This study also would like to determine whether self-esteem factors namely friends, school and family are the main predictors of adolescents’ life satisfaction. This research involved 316 of Form Two students from several secondary school. The data were collected using questionnaires. The research instruments used in this study is Self-Esteem Questionnaires (SEQ) and Multidimensional Students’ Life Satisfaction Scale (MSLSS). This research shows that there is a moderate positive relationship between self-esteem and life satisfaction among adolescents (r = .505). Regression analysis showed that the self-esteem factors namely friends, school and family are significant predictors of life satisfaction among adolescents. The self-esteem factor which is friends has been identified as the strongest predictor (β = .192) of adolescents’ life satisfaction compared to school and family.