This study aims to examine the interrelationship of self-determination, the big five, achievement motivation and academic achievement among students. This questionnaire survey study involving 150 students from the Faculty of Humanities and Social Sciences, The National University of Malaysia. The data obtained in this study were analyzed by using Statistical Package for Social Sciences (SPSS). Instrument that has been used was Learning Self-Regulation Questionnaire (SRQ-L), Big Five Inventory (BFI), and achievement motivation scale (CLAMS). The results showed that the autonomous regulation (r =.40) and controlled regulation (r =.43) were significantly related to achievement motivation. Results also showed that the autonomous regulation (r =.45) and controlled regulation (r =.29) were significantly related to academic achievement. Correlation results also show that the big five personalities, that openness (r =.62), conscientiousness (r =.56), extraversion (r =.61), agreeableness (r =.43) and neuroticism (r =1.58) were significantly related to achievement motivation. The results showed openness (r =.31), conscientiousness (r =.44), extraversion (r =.30), agreeableness (r =.22) and neuroticism (r = -.23) were significantly related to academic achievement. In general, this study explains that self-determination and big five personalities can be used to predict the relationship with achievement motivation and academic achievement.