Oxidative stress resistance and fitness-compensatory response in vancomycin-intermediate Staphylococcus aureus (VISA)

Tan XE 1 , Neoh HM 1 , Cui L 2 , Hiramatsu K 3 , Jamal R 1

Affiliations 

  • 1 a UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Malaysia
  • 2 c Division of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical University, Japan
  • 3 b Department of Bacteriology, School of Medicine, Juntendo University, Japan
Can J Microbiol, 2019 Aug;65(8):623-628.
PMID: 31063703 DOI: 10.1139/cjm-2019-0048

Abstract

In this study, vancomycin-intermediate Staphylococcus aureus (VISA) cells carrying vraS and (or) graR mutations were shown to be more resistant to oxidative stress. Caenorhabditis elegans infected with these strains in turn demonstrated lower survival. Altered regulation in oxidative stress response and virulence appear to be physiological adaptations associated with the VISA phenotype in the Mu50 lineage.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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