Predictive factors of prostate cancer diagnosis with PSA 4.0-10.0 ng/ml in a multi-ethnic Asian population, Malaysia

Yii RSL; Lim J; Sothilingam S; Yeoh WS; Fadzli AN; Ong TA; Kuppusamy S; Abdul Razack AH

doi:10.1016/j.asjsur.2019.02.014

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Predictive factors of prostate cancer diagnosis with PSA 4.0-10.0 ng/ml in a multi-ethnic Asian population, Malaysia

Yii RSL ¹ , Lim J ¹ , Sothilingam S ¹ , Yeoh WS ¹ , Fadzli AN ¹ , Ong TA ¹ Show all authors , Kuppusamy S ¹ , Abdul Razack AH ²

Affiliations

¹ Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
² Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. Electronic address: [email protected]

Asian J Surg, 2020 Jan;43(1):87-94.

PMID: 30962017 DOI: 10.1016/j.asjsur.2019.02.014

Abstract

OBJECTIVES: To identify the associated factors determining prostate cancer detection using transrectal ultrasound (TRUS)-guided prostate biopsy, within a multi-ethnic Malaysian population with prostate specific antigen (PSA) between 4.0 and 10.0 ng/ml.

METHODS: Study subjects included men with initial PSA between 4.0 and 10.0 ng/ml that have undergone 12-core TRUS-guided prostate biopsy between 2009 and 2016. The prostate cancer detection rate was calculated, while potential factors associated with detection were investigated via univariable and multivariable analysis.

RESULTS: A total of 617 men from a multi-ethnic background encompassing Chinese (63.5%), Malay (23.1%) and Indian (13.3%) were studied. The overall cancer detection rate was 14.3% (88/617), which included cancers detected at biopsy 1 (first biopsy), biopsy 2 (second biopsy with previous negative biopsy) and biopsy ≥ 3 (third or more biopsies with prior negative biopsies). Indian men displayed higher detection rate (23.2%) and increased risk of prostate cancer development (OR 1.85, 95% CI 1.03-3.32, p

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.