Anti-infective activities of 11 plants species used in traditional medicine in Malaysia

Nor Azman NS 1 , Hossan MS 1 , Nissapatorn V 2 , Uthaipibull C 3 , Prommana P 3 , Jin KT 1 Show all authors , Rahmatullah M 4 , Mahboob T 5 , Raju CS 6 , Jindal HM 6 , Hazra B 7 , Mohd Abd Razak MR 8 , Prajapati VK 9 , Pandey RK 9 , Aminudin N 10 , Shaari K 11 , Ismail NH 12 , Butler MS 13 , Zarubaev VV 14 , Wiart C 15

Affiliations 

  • 1 School of Pharmacy, Faculty of Science, University of Nottingham Malaysia Campus, 43500 Semenyih, Malaysia
  • 2 School of Allied Health Sciences and Research Excellence Center for Innovation and Health Products (RECIHP), Walailak University, 80161 Nakhon Si Thammarat, Thailand. Electronic address: [email protected]
  • 3 National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Khlong Luang, 12120, Pathum Thani, Thailand
  • 4 Department of Pharmacy, Faculty of Life Science, University of Development Alternative, 1207 Dhaka, Bangladesh. Electronic address: [email protected]
  • 5 Department of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia
  • 6 Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia
  • 7 Department of Pharmaceutical Technology, Jadavpur University, 70032, Kolkata, India
  • 8 Herbal Medicine Research Center, Institute for Medical Research, 50588, Kuala Lumpur, Malaysia
  • 9 Department of Biochemistry, School of Life Sciences, Central University of Rajasthan, 305817 Rajasthan, India
  • 10 Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia
  • 11 Laboratory of Natural Products, Institute of Bioscience, University Putra Malaysia, 43400, Serdang, Malaysia
  • 12 Atta-ur-Rahman Institute for Natural Products Discovery, Universiti Teknologi MARA Puncak Alam, 42300 Kuala Selangor, Malaysia
  • 13 Institute for Molecular Bioscience, University of Queensland, QLD 4072, St Lucia, Australia
  • 14 Pasteur Institute of Epidemiology and Microbiology, 14 Mira str., 197101, St. Petersburg, Russia
  • 15 School of Pharmacy, Faculty of Science, University of Nottingham Malaysia Campus, 43500 Semenyih, Malaysia. Electronic address: [email protected]
Exp Parasitol, 2018 Nov;194:67-78.
PMID: 30268422 DOI: 10.1016/j.exppara.2018.09.020

Abstract

Treatment of drug resistant protozoa, bacteria, and viruses requires new drugs with alternative chemotypes. Such compounds could be found from Southeast Asian medicinal plants. The present study examines the cytotoxic, antileishmanial, and antiplasmodial effects of 11 ethnopharmacologically important plant species in Malaysia. Chloroform extracts were tested for their toxicity against MRC-5 cells and Leishmania donovani by MTT, and chloroquine-resistant Plasmodium falciparum K1 strain by Histidine-Rich Protein II ELISA assays. None of the extract tested was cytotoxic to MRC-5 cells. Extracts of Uvaria grandiflora, Chilocarpus costatus, Tabernaemontana peduncularis, and Leuconotis eugenifolius had good activities against L. donovani with IC50 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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