Annona muricata leaves accelerate wound healing in rats via involvement of Hsp70 and antioxidant defence

Moghadamtousi SZ 1 , Rouhollahi E 2 , Hajrezaie M 1 , Karimian H 3 , Abdulla MA 4 , Kadir HA 5

Affiliations 

  • 1 Biomolecular Research Group, Biochemistry Program, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 2 Department of Pharmacology, Faculty of Medicine, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 3 Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 4 Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 5 Biomolecular Research Group, Biochemistry Program, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: [email protected]
Int J Surg, 2015 Jun;18:110-7.
PMID: 25899210 DOI: 10.1016/j.ijsu.2015.03.026

Abstract

Annona muricata, a member of the Annonaceae family, is commonly known as soursop and graviola. The leaves of this tropical fruit tree are widely used in folk medicine against skin diseases and abscesses, however there is no scientific evidence justifying the use of A. muricata leaves. The aim of the present study is to evaluate the wound healing potential of ethyl acetate extract of A. muricata leaves (EEAM) towards excisional wound models in rats.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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