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Protection by tocotrienols against hypercholesterolaemia and atheroma.

Teoh MK 1 , Chong JMK 2 , Mohamed J 3 , Phang KS 4

Affiliations 

  • 1 M K Teoh, FRCSEd. Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raia Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
  • 2 J M K Chong, BSc (Hons). Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raia Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
  • 3 J Mohamed, PhD. Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raia Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
  • 4 K S Phang, MRCPath. Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raia Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
Med J Malaysia, 1994 Sep;49(3):255-62.
PMID: 7845276

Abstract

Antioxidants such as tocotrienols may protect against atherosclerosis since tissue injury from free radicals is a final common pathway of damage in arterial disease. In this study, the effects of tocotrienols on serum cholesterol, lipid peroxides, and aorta atheroma were assessed in rabbits fed an atherogenic diet for 12 weeks. Tocotrienols were more effective than tocopherols in preventing increases in serum LDL (p = 0.03) and total cholesterol (p = 0.008) levels in the cholesterol-fed rabbits. Elevation of serum lipid peroxides was effectively suppressed by tocotrienols (p = 0.01). Both tocopherols and tocotrienols offered significant protection against atheroma in the rabbit aorta, but tocotrienols had a stronger hypolipidaemic effect.
Comment in: Pathmanathan R, Wong KT. Protection by tocotrienols against hypercholesterolaemia and atheroma. Med J Malaysia. 1995 Mar;50(1):117

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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