Development of poly (1, 8-octanediol citrate)/chitosan blend films for tissue engineering applications

Zeimaran E 1 , Pourshahrestani S 2 , Pingguan-Murphy B 2 , Kong D 3 , Naveen SV 4 , Kamarul T 4 Show all authors , Kadri NA 5

Affiliations 

  • 1 Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia; School of Engineering, Monash University, 47500 Bandar Sunway, Selangor, Malaysia. Electronic address: [email protected]
  • 2 Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 3 School of Engineering, Monash University, 47500 Bandar Sunway, Selangor, Malaysia
  • 4 Tissue Engineering Group (TEG), National Orthopaedic Centre of Excellence in Research and Learning (NOCERAL), Department of Orthopaedic Surgery, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 5 Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: [email protected]
Carbohydr Polym, 2017 Nov 01;175:618-627.
PMID: 28917909 DOI: 10.1016/j.carbpol.2017.08.038

Abstract

Blends of poly (1, 8-octanediol citrate) (POC) and chitosan (CS) were prepared through solution casting technique. Films with different component fractions (POC/CS: 100/0, 90/10, 80/20, 70/30, 60/40, and 0/100) were successfully prepared and characterized for their mechanical, thermal, structural and morphological properties as well as biocompatibility. The incorporation of CS to POC significantly increased tensile strength and elastic modulus and presented limited influences on pH variation which is important to the biocompatibility of biomaterial implants. The assessment of surface topography indicated that blending could enhance and control the surface roughness of the pure films. POC/CS blends well-supported human dermal fibroblast cells attachment and proliferation, and thus can be used for a range of tissue engineering applications.

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