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Effects of immunonutrition on biomarkers in traumatic brain injury patients in Malaysia: a prospective randomized controlled trial

Rai VRH 1 , Phang LF 2 , Sia SF 3 , Amir A 4 , Veerakumaran JS 5 , Kassim MKA 5 Show all authors , Othman R 6 , Tah PC 6 , Loh PS 5 , Jailani MIO 5 , Ong G 5

Affiliations 

  • 1 School of Medicine, Taylor's University, Lakeside Campus, 47500, Subang Jaya, Malaysia
  • 2 Department of Anaesthesiology, Hospital Umum Sarawak, Jalan Hospital, 93586, Kuching, Sarawak, Malaysia
  • 3 Division of Neurosurgery, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia
  • 4 Department of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. [email protected]
  • 5 Department of Anaesthesiology, Faculty of Medicine, University Malaya, 50603, Kuala Lumpur, Malaysia
  • 6 Department of Dietetics, University Malaya Medical Centre, 50603, Kuala Lumpur, Malaysia
BMC Anesthesiol, 2017 06 15;17(1):81.
PMID: 28619005 DOI: 10.1186/s12871-017-0369-4

Abstract

BACKGROUND: Head injury is one of the top three diagnosis leading to intensive care unit (ICU) admission in Malaysia. There has been growing interest in using immunonutrition as a mode of modulating the inflammatory response to injury or infection with the aim of improving clinical outcome. The aim of the present study was to evaluate the effect of an immunonutrition on biomarkers (IL-6, glutathione, CRP, total protein and albumin) in traumatic brain injury patients.

METHODS: Thirty six patients with head injury admitted to neurosurgical ICU in University Malaya Medical Centre were recruited for this study, over a 6-month period from July 2014 to January 2015. Patients were randomized to receive either an immunonutrition (Group A) or a standard (Group B) enteral feed. Levels of biomarkers were measured at day 1, 5 and 7 of enteral feeding.

RESULTS: Patients in Group A showed significant reduction of IL-6 at day 5 (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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