Increased circulating oxidised low-density lipoprotein and antibodies to oxidised low-density lipoprotein in preeclampsia

Arifin R 1 , Kyi WM 1 , Che Yaakob CA 2 , Yaacob NM 3

Affiliations 

  • 1 a Department of Chemical Pathology , School of Medical Sciences, Universiti Sains Malaysia, Health Campus , Kubang Kerian , Malaysia
  • 2 b Department of Obstetrics and Gynaecology , School of Medical Sciences, Universiti Sains Malaysia, Health Campus , Kubang Kerian , Malaysia
  • 3 c Unit of Biostatistics and Research Methodology , School of Medical Sciences, Universiti Sains Malaysia, Health Campus , Kubang Kerian , Malaysia
J Obstet Gynaecol, 2017 Jul;37(5):580-584.
PMID: 28358592 DOI: 10.1080/01443615.2016.1269227

Abstract

Enhanced oxidative stress is involved in the pathogenesis of endothelial dysfunction in preeclampsia (PE). Circulating oxidised LDL (oxLDL) and antibodies to oxLDL (Ab-oxLDL) have been found to be associated with atherosclerosis. The objectives of this study were to investigate the association of oxLDL and Ab-oxLDL with PE and to assess the association between oxLDL and Ab-oxLDL. The levels of oxLDL and Ab-oxLDL were measured by enzyme-linked immunoassay in 78 women with preeclampsia (PE group) and 78 women with normal pregnancy (control group). The PE group had higher oxLDL and Ab-oxLDL levels than the control group (485.1vs.145.9 ng/ml, p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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