The Role of Isocitrate Lyase (ICL1) in the Metabolic Adaptation of Candida albicans Biofilms

Ishola OA 1 , Ting SY 1 , Tabana YM 1 , Ahmed MA 1 , Yunus MA 1 , Mohamed R 2 Show all authors , Lung Than LT 3 , Sandai D 1

Affiliations 

  • 1 Infectomics Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Malaysia
  • 2 Regenerative Medicine Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Malaysia
  • 3 Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia
Jundishapur J Microbiol, 2016 Sep;9(9):e38031.
PMID: 27800147

Abstract

A major characteristic of Candida biofilm cells that differentiates them from free-floating cells is their high tolerance to antifungal drugs. This high resistance is attributed to particular biofilm properties, including the accumulation of extrapolymeric substances, morphogenetic switching, and metabolic flexibility.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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