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Transgenerational effects of paternal heroin addiction on anxiety and aggression behavior in male offspring

Farah Naquiah MZ 1 , James RJ 2 , Suratman S 3 , Lee LS 1 , Mohd Hafidz MI 4 , Salleh MZ 1 Show all authors , Teh LK 5

Affiliations 

  • 1 Integrative Pharmacogenomics Institute (iPROMISE), Level 7, FF3, Universiti Teknologi MARA Selangor, Puncak Alam Campus, 42300, Bandar Puncak Alam, Selangor, Malaysia
  • 2 Integrative Pharmacogenomics Institute (iPROMISE), Level 7, FF3, Universiti Teknologi MARA Selangor, Puncak Alam Campus, 42300, Bandar Puncak Alam, Selangor, Malaysia. [email protected]
  • 3 Faculty of Pharmacy, Universiti Teknologi MARA Selangor, Puncak Alam Campus, 42300, Bandar Puncak Alam, Selangor, Malaysia
  • 4 Comparative Medicine and Technology Unit, Institute Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia
  • 5 Integrative Pharmacogenomics Institute (iPROMISE), Level 7, FF3, Universiti Teknologi MARA Selangor, Puncak Alam Campus, 42300, Bandar Puncak Alam, Selangor, Malaysia. [email protected]
Behav Brain Funct, 2016 Aug 31;12(1):23.
PMID: 27582026 DOI: 10.1186/s12993-016-0107-y

Abstract

Heroin addiction is a growing concern, affecting the socioeconomic development of many countries. Little is known about transgenerational effects on phenotype changes due to heroin addiction. This study aims to investigate changes in level of anxiety and aggression up to four different generations of adult male rats due to paternal exposure to heroin.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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