[OP.3A.01] THE COMPARISON OF THE TRANSCRIPTOME PROFILE OF THE AUTONOMOUS AND THE PHYSIOLOGICAL ALDOSTERONE-PRODUCING TISSUE, THE ALDOSTERONE-PRODUCING ADENOMA AND THE ZONA GLOMERULOSA

Zhou J 1 , Lam BY , Neogi SG , Yeo GS , Teo AE , Maniero C Show all authors , Azizan EA , Brown MJ

Affiliations 

  • 1 1Clinical Pharmacology Unit, Department of Medicine, University of Cambridge, Addenbrookes Hospital, Cambridge, UNITED KINGDOM 2MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Cambridge, UNITED KINGDOM 3Department of Clinical Biochemistry, Genomics CoreLab, Cambridge National Institute for NIHR BRC, Cambridge, UNITED KINGDOM 4Department of Medicine, Faculty of Medicine, The National University of Malaysia (UKM) Medical Centre, Kuala Lumpur, MALAYSIA
J Hypertens, 2016 Sep;34 Suppl 2:e26.
PMID: 27508643 DOI: 10.1097/01.hjh.0000491398.48468.bf

Abstract

Primary aldosteronism (PA) is the most common type of secondary hypertension occurring in ∼10% of hypertensive patients. Up to 50% of PA is caused by aldosterone-producing adenomas (APA). We recently performed a microarray assay using 21 pairs of zona glomerulosa (ZG) and zona fasciculata (ZF), and 14 paired APAs. This study is to identify the potential biological processes and canonical pathways involved with aldosterone regulation, APA formation, or APA and ZG cell functions.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications