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A recombinant 19 kDa Plasmodium berghei merozoite surface protein 1 formulated with alum induces protective immune response in mice

Wan Omar, A. 1 , Roslaini, A.M. 1 , Ngah, Z.U. 1 , Azahari, A.A. 2 , Zahedi, M. 3 , Baharudin, O. 4

Affiliations 

  • 1 Universiti Putra Malaysia
  • 2 Universiti Industri Selangor
  • 3 Universiti Darul Iman Malaysia
  • 4 Universiti Kebangsaan Malaysia
Trop Biomed, 2007;24(1):119-126.
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Abstract

We investigated the immunogenicity of recombinant rMSP1 (rPbMSP1) that was
generated from Plasmodium berghei. The rPbMSP1 formulated in alum was found to be
immunogenic which induced high levels of specific anti-rPbMSP1 antibody. The IgG2a response
predominated over IgG1 during the challenge infection in the vaccinated mice. Mice vaccinated
with rPbMSP1 in alum mounted significant protective immunity against challenge infection
(P

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